A5060400114- Immune Cell Function and Interaction
- HIV Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Blood disorders and treatments
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- Interprofessional Education and Collaboration
- Alzheimer's disease research and treatments
- Immune responses and vaccinations
- Reproductive System and Pregnancy
- Prion Diseases and Protein Misfolding
- Immunotherapy and Immune Responses
- interferon and immune responses
- Simulation-Based Education in Healthcare
- Atherosclerosis and Cardiovascular Diseases
- Health and Medical Studies
- Reproductive tract infections research
- Chronic Lymphocytic Leukemia Research
- Microscopic Colitis
- Diabetes and associated disorders
- Herpesvirus Infections and Treatments
Linköping University
2015-2025
University Hospital of Bern
2021
University of Bern
2021
The University of Melbourne
2014
Uppsala University
2002
University of Tennessee at Knoxville
2002
The generation of amyloid fibrils from an amyloidogenic polypeptide occurs by a nucleation-dependent process initiated in vitro seeding the protein solution with preformed fibrils. This phenomenon is evidenced vivo fact that A (AA) amyloidosis mice markedly accelerated when animals are given, addition to inflammatory stimulus, i.v. injection extracted AA amyloid-laden mouse tissue. Heretofore, chemical nature this “amyloid enhancing factor” (AEF) has not been definitively identified. Here we...
COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of disease on immune cells. The different arms system are interlinked, with humoral responses production high-affinity antibodies largely dependent T cell immunity. Here, we longitudinally explored effect has populations virus-specific cells, as well neutralizing antibody responses, for 6-7 months following hospitalization. CD8 + TEMRA exhausted CD57 cells were markedly affected elevated...
Introduction After more than two years the Coronavirus disease-19 (COVID-19) pandemic continues to burden healthcare systems and economies worldwide, it is evident that effects on immune system can persist for months post-infection. The activity of myeloid cells such as monocytes dendritic (DC) essential correct mobilization innate adaptive responses a pathogen. Impaired levels DC severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely be driving force behind dysregulation...
Individuals with chronic lymphocytic leukemia (CLL) face increased risk of severe COVID-19. This study from Sweden, a country few mandatory restrictions at the onset pandemic, used 10 nationwide registers to compare risks COVID-19 outcomes PCR-verified SARS-CoV-2 infections through February 2023 in individuals vs without CLL. From population 8,275,839 (6,653 CLL) born 1930-2003, 2,088,163 first (1,289 were included. The 90-day all-cause mortality rate and adjusted relative (aRR [95% CI]) for...
The hallmark of HIV-1 infection is the progressive development multicellular and systemic immune dysfunction, culminating in AIDS. Dendritic cells (DCs) play a pivotal role HIV dissemination to CD4+ T cells, which are subsequently depleted by virus leading disease progression. Type I interferons (IFNs) critical for host defense during acute but contribute chronic activation later stages disease. This persistent leads cell exhaustion. can activate type IFN responses via several pathways,...
Background/Objectives: One of the risk groups during COVID-19 pandemic was people with predominantly antibody deficiencies (PADs) that have a compromised immune system. In absence evidence and clinical experience, there were challenges for patients in their daily life staff counseling this time. Therefore, aim study to explore experiences PAD nurses pandemic. Methods: Focus group interviews (n = 12) performed separately, which then analyzed using content analysis. Results: The affected...
Spongiform encephalopathies have been reported to be transmitted by blood transfusion even prior the clinical onset. Experimental AA-amyloidosis shows similarities with prion disease and amyloid-containing organ-extracts can prime a recipient for disease. In this systemic form of amyloidosis N-terminal fragments acute-phase reactant apolipoprotein serum amyloid A are main protein. Initial deposits appear in perifollicular region spleen, followed liver. We used established murine model...
Depletion of Foxp3(+) CD4(+) regulatory T cells (Treg) in adults results chronic inflammation and autoimmune disease. However, the impact transient Treg-cell depletion on self-reactive responses is poorly defined. Here, we studied effect Treg T-cell to endogenous self-antigens. Short-term ablation mice resulted rapid activation cells, increased percentage IFN-γ(+) Th17 lymphoid organs, development gastritis. To track responses, analyzed naïve gastric-specific cells. There was a dramatic...
BackgroundCommon variable immunodeficiency (CVID) is a disorder characterized by antibody deficiency. A significant fraction of the patients suffer from immune dysregulation, which leads to increased morbidity and mortality. The pathogenesis this condition poorly understood.ObjectiveOur aim was find out whether plasma protein signature in CVID associated with clinical characteristics lymphocyte aberrations.MethodsA highly sensitive proximity extension assay used for targeted profiling 145...
AA amyloidosis is a complication to longstanding inflammatory diseases, but reduction of amyloid mass has been reported as the inflammation ceases. Not much known about endogenous factors that contribute this resolution. Herein, we describe dynamics degradation and resolution in experimental murine AA-amyloidosis.AA-amyloidosis was induced mice with injections enhancing factor (AEF) by silver nitrate. Resolution deposits monitored over time.Virtually all cleared within 34 weeks. Using...
Abstract Background Multiple host factors may influence immune reconstitution in HIV-infected people after the initiation of suppressive antiretroviral therapy (ART). Aberrant metabolic pathways have been reported with HIV (PWH) on ART. We hypothesized that alterations plasma metabolites were associated recovery following Methods In this cross-sectional study, metabolomic profiles PWH ART evaluated. slow and fast classified by increase CD4 T cells 2 years Targeted metabolite profiling liquid...
Dysregulated chronic inflammation plays a crucial role in the pathophysiology of atherosclerosis and may be result impaired resolution. Thus, restoring levels specialized pro-resolving mediators (SPMs) to promote resolution has been proposed as therapeutic strategy for patients with atherosclerosis, addition standard clinical care. Herein, we evaluated effects SPM lipids, lipoxin A4 (LXA4) B4 (LXB4), on neutrophils isolated from compared healthy controls. Patients displayed altered...
ABSTRACT Herpes simplex virus 2 (HSV-2) is one of the most common sexually transmitted infections globally, with a very high prevalence in many countries. During HSV-2 infection, viral particles become coated complement proteins and antibodies, both present genital fluids, which could influence activation immune responses. In mucosa, primary target cells for infection are epithelial cells, but resident such as dendritic (DCs), also infected. DCs activators ensuing responses directed against...
Mucosa resident dendritic cells (DCs) may represent one of the first immune that HIV-1 encounters during sexual transmission. The virions in body fluids can be opsonized with complement factors because HIV-mediated triggering cascade, and this appears to influence numerous aspects defense targeting virus. One key attribute host is ability attract site infection. In study, we investigated whether opsonization HIV (C-HIV) or a mixture Abs (CI-HIV) affected cytokine chemokine responses...
Genital herpes is a common sexually transmitted infection caused by simplex virus type 2 (HSV-2). significantly enhances the acquisition and transmission of HIV-1 creating microenvironment that supports HIV in host. Dendritic cells (DCs) represent one first innate cell types encounter HSV-2 genital mucosa. has been shown to modulate DCs, rendering them more receptive infection. Here, we investigated potential mechanisms underlying HSV-2-mediated augmentation We demonstrated presence enhanced...
Dendritic cells (DCs), natural killer (NK) and T play critical roles during primary HIV-1 exposure at the mucosa, where viral particles become coated with complement fragments mucosa associated antibodies. The microenvironment together subsequent interactions between these HIV mucosal site of infection will determine quality immune response that ensues adaptive activation. Here, we investigated how immunoglobulin opsonization influences responses triggered in DCs NK cells, this affects their...
Abstract The pro-inflammatory and regulatory roles of T lymphocytes in atherosclerosis are well established but less is known about natural killer (NK) cells (NKT)-like cells. effects cardiovascular risk management on the phenotypes these unknown. To assess changes NK cell lymphocyte circulating inflammatory proteins response to patients with carotid atherosclerosis. Fifty were included a prospective clinical study. Measurements at baseline after 12 months management. Circulating NK,...
Background Immunoglobulin G subclass deficiencies (IgGsd) comprise a wide clinical spectrum from no symptoms to repeated respiratory infections and risk for the development of lung damage. Our aims were investigate whether immunological phenotype IgGsd patients on off immunoglobulin replacement therapy (IgRT) was reflected in features IgGsd. Method Thirty with included this prospective study 18 months IgRT, followed by 7-18 IgRT discontinuation. Blood samples collected when compared 34...
Purpose Individuals with immunoglobulin G deficiency (IgGsd) often complain of fatigue. The correlation between systemic inflammation and fatigue is unknown. In this study perceived quality life (QoL) in individuals IgGsd, on off replacement therapy (IgRT) were correlated to inflammatory markers plasma identify the subgroup that benefits from IgRT. Method Thirty-five IgGsd-patients sampled three occasions: at baseline, after being IgRT for least 18 months, months discontinuation Short form...
Abstract Background The immune response to SARS-CoV-2 virus, the cause of COVID-19, is complex. Antibody mediated responses are important for viral clearance but may also drive hyperinflammation in severe COVID-19. We present a case an individual with genetic inability produce antibodies and receiving no other specific anti-viral treatment than convalescent COVID-19 plasma, illustrating that can occur absence humoral response. In addition, illustrates assessment T cell facilitate clinical...
Norovirus is the most common cause of acute non-bacterial gastroenteritis. Immunocompromised patients can become chronically infected, with or without symptoms. In Europe, variable immunodeficiency (CVID) one inborn errors immunity. A potentially severe complication CVID-associated enteropathy, a disorder similar histopathology to celiac disease. Studies suggest that chronic norovirus infection may be contributor CVID and antiviral drug ribavirin effective against norovirus. Here, patient...
The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during COVID-19 pandemic regarding clinical course severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Herein, we investigated predictive value pCRP mCRP for severity hospitalized patients evaluated how levels changed over time after illness. This study utilized samples from a well-characterized cohort Swedish with...