A5050519937- HIV Research and Treatment
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
- Systemic Lupus Erythematosus Research
- Reproductive tract infections research
- Immunodeficiency and Autoimmune Disorders
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Social and Educational Sciences
- Early Childhood Education and Development
- HIV/AIDS oral health manifestations
- T-cell and B-cell Immunology
- Immune cells in cancer
- Mosquito-borne diseases and control
- Galectins and Cancer Biology
- Inflammasome and immune disorders
Linköping University
2018-2023
COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of disease on immune cells. The different arms system are interlinked, with humoral responses production high-affinity antibodies largely dependent T cell immunity. Here, we longitudinally explored effect has populations virus-specific cells, as well neutralizing antibody responses, for 6-7 months following hospitalization. CD8 + TEMRA exhausted CD57 cells were markedly affected elevated...
Introduction After more than two years the Coronavirus disease-19 (COVID-19) pandemic continues to burden healthcare systems and economies worldwide, it is evident that effects on immune system can persist for months post-infection. The activity of myeloid cells such as monocytes dendritic (DC) essential correct mobilization innate adaptive responses a pathogen. Impaired levels DC severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely be driving force behind dysregulation...
Presence of autoantibodies targeting nuclear constituents, i.e., double-stranded DNA and small ribonucleoproteins (snRNPs), remain a cornerstone in systemic lupus erythematosus (SLE). Fcγ receptor IIa (FcγRIIa) dependent uptake nucleic acid containing immune complexes (ICs) by plasmacytoid dendritic cells (PDCs) can activate toll-like receptors (TLRs) such as TLR7 TLR9 resulting type I interferon (IFN) production. Previously, the classical liver-derived acute-phase reactant C-reactive...
The hallmark of HIV-1 infection is the progressive development multicellular and systemic immune dysfunction, culminating in AIDS. Dendritic cells (DCs) play a pivotal role HIV dissemination to CD4+ T cells, which are subsequently depleted by virus leading disease progression. Type I interferons (IFNs) critical for host defense during acute but contribute chronic activation later stages disease. This persistent leads cell exhaustion. can activate type IFN responses via several pathways,...
Objectives Type I interferons (IFNs) are central and reflective of disease activity in systemic lupus erythematosus (SLE). However, IFN-α levels notoriously difficult to measure the type IFN gene signature (IGS) is not yet available clinical routine. This study evaluates galectin-9 an array chemokines/cytokines their potential as surrogate markers and/or SLE activity. Methods Healthy controls well-characterized Swedish patients from two cross-sectional cohorts ( n =181; =59) were included, a...
Genital herpes is a common sexually transmitted infection caused by simplex virus type 2 (HSV-2). significantly enhances the acquisition and transmission of HIV-1 creating microenvironment that supports HIV in host. Dendritic cells (DCs) represent one first innate cell types encounter HSV-2 genital mucosa. has been shown to modulate DCs, rendering them more receptive infection. Here, we investigated potential mechanisms underlying HSV-2-mediated augmentation We demonstrated presence enhanced...
Dendritic cells (DCs), natural killer (NK) and T play critical roles during primary HIV-1 exposure at the mucosa, where viral particles become coated with complement fragments mucosa associated antibodies. The microenvironment together subsequent interactions between these HIV mucosal site of infection will determine quality immune response that ensues adaptive activation. Here, we investigated how immunoglobulin opsonization influences responses triggered in DCs NK cells, this affects their...
The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during COVID-19 pandemic regarding clinical course severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Herein, we investigated predictive value pCRP mCRP for severity hospitalized patients evaluated how levels changed over time after illness. This study utilized samples from a well-characterized cohort Swedish with...
HIV transmission via genital and colorectal mucosa are the most common routes of dissemination. Here, we explored effects free complement-opsonized on tissue. Initially, there was higher antiviral responses in compared to virus. The mucosal transcriptional response at 24 hr revealed involvement activated T cells, which mirrored cellular observed 96 isolated cells. Further, exposure led skewing cell phenotypes predominantly inflammatory CD4+ that is Th17 Th1Th17 subsets. Of note, created an...
HIV-1 infection gives rise to a multi-layered immune impairment in most infected individuals. The chronic presence of during the priming and activation T cells by dendritic (DCs) promotes expansion suppressive contact-dependent manner. mechanism behind cell side this HIV-induced is well studied, whereas little known about reverse effects exerted on DCs. Herein we assessed phenotype transcriptome profile mature DCs that have been contact with cells. HIV exposed from cocultures between...
Abstract The emergence of SARS-CoV-2 has had a profound adverse impact on global health and continues to remain threat worldwide. disease spectrum COVID-19 ranges from asymptomatic fatal clinical outcomes especially in the elderly population individuals with underlying medical conditions. host immune responses cells at protein DNA levels remains largely ambiguous. In case-control study, here we explored methylation patterns upper respiratory airway determine how infection altered status...
Genital mucosal transmission is the most common route of HIV spread. The initial responses triggered at site viral entry are reportedly affected by host factors, especially complement components present site, and this will have profound consequences on outcome pathogenesis infection. We studied events associated with host-pathogen interactions exposing cervical biopsies to free or complement-opsonized HIV. Opsonization resulted in higher rates acquisition/infection tissues emigrating...
Abstract COVID-19 is being extensively studied, and much remains unknown regarding the long-term consequences of disease on immune cells. The different arms system are interlinked, with humoral responses production high-affinity antibodies largely dependent T cell immunity. Here, we longitudinally explored effect has populations virus-specific cells, as well neutralizing antibody responses, for 6-7 months following hospitalization. CD8 + TEMRA exhausted CD57 cells were markedly affected...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is an autoimmune systemic disease affecting multiple organs and which characterized by autoantibodies directed against nuclear constituents. Common autoantibody targets include double-stranded (ds) DNA small ribonucleoproteins (snRNPs; i.e. U1-snRNP). Uptake of immune complexes (ICs) plasmacytoid dendritic cells (pDCs) can activate endosomal toll-like receptors (TLRs) such as TLR-7 TLR-9 if nucleic acids are present in the ICs. Such...
ABSTRACT After more than two years the COVID-19 pandemic continues to burden healthcare systems and economies worldwide, it is evident that long-term effects of disease can persist for months post-recovery in some individuals. The activity myeloid cells such as monocytes dendritic (DC) essential correct mobilization innate adaptive responses a pathogen. Impaired levels DC SARS-CoV-2 likely be driving force behind immune dysregulation characterizes severe COVID-19. Here, we followed, 6-7...
Abstract HIV-1 infection gives rise to a multilayered immune impairment in most infected individuals. The crosstalk between Dendritic cells and T plays an important part the induction of responses. chronic presence human immunodeficiency virus (HIV)-1 during dendritic (DCs) priming activation promotes expansion suppressor contact dependent manner. mechanism behind cell side this HIV induced is well studied, whereas little known about reverse effects exerted on DCs setting. Here we assessed...