Gerome Breen
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Eating Disorders and Behaviors
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Cognitive Abilities and Testing
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Long-Term Effects of COVID-19
- Birth, Development, and Health
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- Obesity, Physical Activity, Diet
- Genetic and phenotypic traits in livestock
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- Schizophrenia research and treatment
- Nutrition, Genetics, and Disease
- COVID-19 Clinical Research Studies
- Health disparities and outcomes
King's College London
2016-2025
Maudsley Hospital
2016-2025
South London and Maudsley NHS Foundation Trust
2016-2025
National Institute for Health Research
2016-2025
University of Liverpool
2022-2025
National Hospital for Neurology and Neurosurgery
2020-2024
Centre for Mental Health
2014-2024
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2012-2024
NIHR Maudsley Dementia Biomedical Research Unit
2010-2024
University College London
2016-2024
Abstract Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which progressively increased in number with increasing sample sizes the respective studies. Here, we conduct genome-wide association study 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification Diseases (ICD, version 9 or 10)-coded MDD....
To improve the 'personalized-medicine' approach to treatment of depression, we need identify biomarkers that, assessed before starting treatment, predict future response antidepressants ('predictors'), as well that are targeted by and change longitudinally during ('targets'). In this study, tested leukocyte mRNA expression levels genes belonging glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, GR), inflammation (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, macrophage...
<h3>Context</h3> Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). <h3>Objective</h3> To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. <h3>Design</h3> Discovery-phase proteomics to correlates pathology. Confirmation validation immunodetection replication set an animal model. <h3>Setting</h3> A multicenter European study (AddNeuroMed) the Baltimore Longitudinal Study Aging....