A5029151960- Immunodeficiency and Autoimmune Disorders
- Biomedical Text Mining and Ontologies
- Blood disorders and treatments
- Tracheal and airway disorders
- Cystic Fibrosis Research Advances
- Natural Language Processing Techniques
- Mobile Health and mHealth Applications
- Scientific Computing and Data Management
- Platelet Disorders and Treatments
- Telemedicine and Telehealth Implementation
- Chronic Lymphocytic Leukemia Research
- Social Media in Health Education
- Computer Graphics and Visualization Techniques
- Health Literacy and Information Accessibility
- Data Mining Algorithms and Applications
- Persona Design and Applications
- Semantic Web and Ontologies
- Advanced Vision and Imaging
- Multimedia Communication and Technology
- Distributed and Parallel Computing Systems
- Electronic Health Records Systems
- Pancreatic and Hepatic Oncology Research
- Genomics and Rare Diseases
- Advanced Data Storage Technologies
- Clinical practice guidelines implementation
Technical University of Munich
2022-2024
University of Freiburg
2018-2024
Klinikum rechts der Isar
2022-2024
Artificial Intelligence in Medicine (Canada)
2024
Institute of Art
2024
University Medical Center Freiburg
2018-2023
Activated Phosphoinositide 3-kinase (PI3K) δ Syndrome (APDS), caused by autosomal dominant mutations in PIK3CD (APDS1) or PIK3R1 (APDS2), is a heterogeneous primary immunodeficiency. While initial cohort-descriptions summarized the spectrum of clinical and immunological manifestations, questions about long-term disease evolution response to therapy remain. The prospective European Society for Immunodeficiencies (ESID)-APDS registry aims characterize course, identify outcome predictors...
Introduction: The German PID-NET registry was founded in 2009, serving as the first national of patients with primary immunodeficiencies (PID) Germany. It is part European Society for Immunodeficiencies (ESID) registry. purpose to gather data on epidemiology, diagnostic delay, diagnosis, and treatment PIDs. Methods: Clinical laboratory collected from 2,453 36 PID centres an online Data analysed software Stata® Excel. Results: minimum prevalence Germany 2.72 per 100,000 inhabitants. Among...
Lately, pre-trained language models advanced the field of natural processing (NLP). The introduction Bidirectional Encoders for Transformers (BERT) and its optimized version RoBERTa have had significant impact increased relevance models. First, research in this mainly started on English data followed by trained with multilingual text corpora. However, current shows that are inferior to monolingual Currently, no German single model is yet published, which we introduce work (GottBERT). portion...
(1) Background: Next-generation sequencing (NGS) of patients with advanced tumors is becoming an established method in Molecular Tumor Boards. However, somatic variant detection, interpretation, and report generation, require in-depth knowledge both bioinformatics oncology. (2) Methods: MIRACUM-Pipe combines many individual tools into a seamless workflow for comprehensive analyses annotation NGS data including quality control, alignment, calling, copy number variation estimation, evaluation...
The National Library of Medicine (NLM) controls and publishes the thesaurus Medical Subject Headings which is used for indexing PubMed. Besides an XML export, NLM offers a web based MeSH browser. platform contains English terms. German Institute Documentation Information (DIMDI) partially translated published these Recently, (ZB-MED) overtook translation MeSH. However, there no dedicated focuses on covers multiple languages. Here, we address this gap, by offering modern multilingual...
Medical Subject Headings (MeSH) is one of the most important vocabularies for information retrieval in medical research. It enables fast and reliable research on PubMed/MEDLINE, world's largest body literature. The original English version thesaurus can be accessed via a MeSH Browser developed by NLM. Recently, multilingual was proposed to enable usage across languages. To improve upon system, new user interface (UI) using contemporary web design frameworks combination with principles from...
Abstract Summary Primary Immunodeficiencies (PIDs) belong to the group of rare diseases. The European Society for (ESID) operates an international research database application continuous long-term documentation patient data. system is a web which runs in standard browser. Therefore, easy access from any location. Technically, based on Gails backed by MariaDB with high security features comply demands modern platform. Availability and implementation ESID Online Database accessible via...
Abstract Objective i2b2 offers the possibility to store biomedical data of different projects in subject oriented marts warehouse, which potentially requires replication between and also synchronization case changes. We present an approach that can save this effort assess its query performance a study reflects real-world scenarios. Material Methods For segregation, we used PostgreSQL’s row level security (RLS) feature, unit test framework pgTAP for validation testing as well application. No...
<sec> <title>BACKGROUND</title> The internet has become a common source of health-related information, highlighting the growing reliance on digital platforms for healthcare knowledge. quality health information obtained from popular search engines may vary, posing challenges to users in evaluating and reliability these websites, especially individuals with low literacy literacy. Therefore, new engine was developed 2020, goal providing access high-quality, evidence-based content addressing...
In medical data science, FHIR provides an increasingly used information model, which will lead to the creation of warehouses in future. To efficiently work with a FHIR-based representation, users need visual representation. The modern UI framework ReactAdmin (RA) enhances usability by leveraging current web standards such as React and Material Design. Rapid development implementation usable UIs is made possible its high modularity many widgets available framework. For connection different...
The German Network on Primary Immunodeficiency Diseases (PID-NET) utilizes the European Society for Immunodeficiencies (ESID) registry as a platform collecting data. In context of PID-NET data, we show how registries based custom software can be made interoperable better collaborative access to precollected Open Source Registry System Rare (Open-Source-Registersystem für Seltene Erkrankungen [OSSE], in German) provides patient organizations, physicians, scientists, and other parties with...
The traditional manual recording of vaccination records in Germany faced challenges during the COVID-19 pandemic, prompting introduction a Covid smartphone app with QR codes. However, this solution brought new challenges, emphasizing need for centrally managed European digital record efficiency and validity. Thus, study assesses feasibility using HL7 FHIR standard healthcare industry implementing pass management monitoring system. system aims to offer convenience improved both patients...
The traditional manual recording of vaccination records in Germany faced challenges during the COVID-19 pandemic, prompting introduction a COVID smartphone app with QR codes. However, this solution brought new challenges, emphasizing need for centrally managed European digital record efficiency and validity. This study assesses feasibility using HL7 FHIR standard healthcare industry implementing pass management monitoring system. system aims to offer convenience improved both patients...
Visualization of volumetric data holds great importance, particularly in medical and biomedical applications. Various imaging techniques, such as FMRI 3D microscopy, are employed to generate data, used practice, research, teaching. Commonly utilized tools like Slicer, Fiji, MATLAB ® aid rendering analyzing images. However, these may lack comprehensive functionality face challenges handling computational demands sizes grow. To address limitations, this work introduces a GPU-supported renderer...
Background The internet is a key source of health information, but the quality content from popular search engines varies, posing challenges for users—especially those with low or digital literacy. To address this, “tala-med” engine was developed in 2020 to provide access high-quality, evidence-based content. It prioritizes German websites based on trustworthiness, recency, user-friendliness, and comprehensibility, offering category-based filters while ensuring privacy by avoiding data...
Traditional tools, such as 3D Slicer, Fiji, and MATLAB®, often encounter limitations in rendering performance data management the dataset sizes increase. This work presents a GPU-enabled volume renderer with MATLAB® interface that addresses these issues. The proposed uses flexible memory leverages GPU texture-mapping features of NVIDIA devices. It transfers between CPU only case change renderings, texture to make use specific hardware benefits improve quality. A study using ViBE-Z zebrafish...
Background: Lymphoproliferation and autoimmune cytopenias characterize autoimmune-lymphoproliferative syndrome (ALPS). Other conditions sharing these manifestations have been termed “ALPS-like”, although they are frequently more severe. Insufficient information on the genetic, clinical immunological features of disorders renders their diagnostic classification treatment difficult.Methods: We performed a 14-year prospective study 431 children referred for ALPS evaluation with...
Data extraction, visualization and distribution is an important task in the daily work of a database management team. In medical field requests are often made by researchers who use spreadsheet programs such as Excel. Thus, we developed framework which allows us to extract tables with 1:N relations sparse prevents redundant information. The Framework implemented PHP using JSON interface. Further, offer connectors for direct connection Postgres database.
<sec> <title>BACKGROUND</title> The German Network on Primary Immunodeficiency Diseases (PID-NET) utilizes the European Society for Immunodeficiencies (ESID) registry as a platform collecting data. In context of PID-NET data, we show how registries based custom software can be made interoperable better collaborative access to precollected Open Source Registry System Rare (<i>Open-Source-Registersystem für Seltene Erkrankungen</i> [OSSE], in German) provides patient organizations,...
A significant portion of data in Electronic Health Records is only available as unstructured text, such surgical or finding reports, clinical notes and discharge summaries. To use this for secondary purposes, natural language processing (NLP) tools are required to extract structured information. Furthermore, interoperable use, harmonization the necessary. HL7 Fast Healthcare Interoperability Resources (FHIR), an emerging standard exchanging healthcare data, defines a format. For...