Bernd Gruhn
A5022487135- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- CAR-T cell therapy research
- Renal and related cancers
- Drug Transport and Resistance Mechanisms
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Neuroblastoma Research and Treatments
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Neonatal Health and Biochemistry
- Prenatal Screening and Diagnostics
- Cancer therapeutics and mechanisms
- Renal Transplantation Outcomes and Treatments
- Autoimmune and Inflammatory Disorders Research
Jena University Hospital
2016-2025
Schiller International University
2003-2023
Friedrich Schiller University Jena
2009-2021
Novartis (Switzerland)
2021
University Hospital Münster
2021
Klinik und Poliklinik für Kinder- und Jugendmedizin
1998-2020
St James's University Hospital
2020
Emmes (United States)
2020
Dana-Farber Cancer Institute
2020
St Anna Children's Hospital
2015
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present data obtained from 2345 leukemia patients. Genomic breakpoints within MLL involved translocation partner genes (TPGs) were determined 11 novel TPGs identified. Thus, a total 135 different have been identified so far, which 94 now characterized at molecular level. In all, 35 out these occur recurrently, but only 9 specific fusions account for...
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is life-threatening complication of HCT that belongs group diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within weeks; however, severe results multi-organ dysfunction/failure with rate >80%. A timely diagnosis critical...
Blinatumomab is a CD3/CD19-directed bispecific T-cell engager molecule with efficacy in children relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL).To evaluate event-free survival high-risk first-relapse B-ALL after third consolidation course blinatumomab vs chemotherapy before allogeneic hematopoietic stem cell transplant.In this randomized phase 3 clinical trial, patients were enrolled November 2015 to July 2019 (data cutoff, 17, 2019). Investigators at 47 centers 13...
Purpose Although hematopoietic stem-cell transplantation is widely performed in children with high-risk acute lymphoblastic leukemia (ALL), the influence of donor types poorly understood. Thus, outcomes were compared prospective multinational Berlin-Frankfurt-Muenster (BFM) study group trial: ALL-SCT-BFM 2003 (Allogeneic Stem Cell Transplantation Children and Adolescents Acute Lymphoblastic Leukemia). Patients Methods After conditioning total-body irradiation etoposide, 411 ALL received...
Purpose We recently reported that children with acute leukemias who show increasing mixed chimerism (MC) after allogeneic stem-cell transplantation have a significantly enhanced risk of relapse. Here we present the results prospective multicenter study to investigate (1) whether relapse lymphoblastic leukemia (ALL) can be determined in advance by serial analysis chimerism, and (2) if outcome influenced withdrawal immunosuppression and/or low-dose donor lymphocyte infusion when MC is...
Advanced systemic mastocytosis (SM), a fatal hematopoietic malignancy characterized by drug resistance, has no standard therapy. The effectiveness of allogeneic stem-cell transplantation (alloHCT) in SM remains unknown.In global effort to define the value HCT SM, 57 patients with following subtypes were evaluated: associated clonal hematologic non-mast cell disorders (SM-AHNMD; n = 38), mast leukemia (MCL; 12), and aggressive (ASM; 7). Median age was 46 years (range, 11 67 years). Donors...
Summary Transplantation of T ‐ and B ‐cell depleted allografts from haploidentical family donors was evaluated within a prospective phase II trial in children with acute lymphoblastic leukaemia, myeloid leukaemia advanced myelodysplastic syndrome ( n = 46). 20 patients had active disease; 19 received second or third stem cell transplantation SCT ). Toxicity‐reduced conditioning regimens consisted fludarabine clofarabine (in disease only), thiotepa, melphalan serotherapy. Graft manipulation...
Fanconi anemia (FA) is a genetically and phenotypically heterogenous autosomal recessive disease associated with chromosomal instability hypersensitivity to DNA crosslinkers. Prognosis poor due progressive bone marrow failure increased risk of neoplasia, but revertant mosaicism may improve survival. Mechanisms reversion include back mutation, intragenic crossover, gene conversion compensating deletions/insertions. We describe the types reversions found in five mosaic FA patients who are...
Abstract Background: Monitoring of minimal residual disease (MRD) has become a strong diagnostic tool in acute lymphoblastic leukemia. It is used for risk-adapted therapy and the recognition pending relapses. In myeloid leukemia (AML), there still need more suitable MRD markers. Experimental Design: A stepwise approach which combined genome-wide expression profiling, TaqMan low density arrays, real-time PCR-based screening was to identify new markers monitoring AML. Leukemic cells from 52...
Abstract Background: A major issue in the treatment of acute myeloid leukemia (AML) is resistance to chemotherapeutic drugs. Multidrug can be caused by ATP-binding cassette (ABC) transporters that function as drug efflux pumps. The majority these proteins have not yet been examined malignant diseases. Experimental Design: newly developed microarray for simultaneous quantification 38 ABC transporter genes and Taqman real-time PCR was used analyze expression pediatric AML healthy bone marrow....
Objectives Patients with systemic lupus erythematosus (SLE) refractory to conventional immunosuppression suffer substantial morbidity and mortality due active disease treatment toxicity. Immunoablation followed by autologous stem cell transplantation (ASCT) is a novel therapeutic strategy that potentially offers new hope these patients. Methods This retrospective survey reviews the efficacy safety of ASCT in 28 SLE patients from eight centres reported European Group for Blood Marrow...
Objective Using multidisciplinary treatment modalities the majority of children with cancer can be cured but we are increasingly faced therapy-related toxicities. We studied brain morphology and neurocognitive functions in adolescent young adult survivors childhood acute, low standard risk lymphoblastic leukemia (ALL), which was successfully treated chemotherapy. expected that intravenous intrathecal chemotherapy administered will affect grey matter structures, including hippocampus...
Highlights•Haploidentical stem cell transplantation is a feasible and safe treatment option that can induce long-term remission in some patients.•A melphalan-based conditioning regimen yields the opportunity to transplant cells with low rates of TRM, toxicity, GVHD even highly pretreated patients.AbstractPediatric patients refractory or relapsed metastatic neuroblastoma (NBL) have poor prognosis despite autologous (SCT). Allogeneic SCT from haploidentical donor has remarkable alloreactive...