A5078285983- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Myeloid Leukemia Treatments
- Oral health in cancer treatment
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Sarcoidosis and Beryllium Toxicity Research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Head and Neck Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Renal cell carcinoma treatment
- Long-Term Effects of COVID-19
- Cancer Treatment and Pharmacology
- Nausea and vomiting management
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Protein Degradation and Inhibitors
Wojskowy Instytut Medycyny Lotniczej
2016-2025
Medical University of Warsaw
2014-2024
Wojskowy Instytut Medyczny
1998-2022
Reckitt Benckiser (United States)
2019
National Academy of Medicine
2014-2015
Central Clinical Hospital
2005-2015
Military Communication Institute
2007-2014
Centrum Onkologii
2013
University of Lisbon
2012
University of Ljubljana
2012
Objectives Patients with systemic lupus erythematosus (SLE) refractory to conventional immunosuppression suffer substantial morbidity and mortality due active disease treatment toxicity. Immunoablation followed by autologous stem cell transplantation (ASCT) is a novel therapeutic strategy that potentially offers new hope these patients. Methods This retrospective survey reviews the efficacy safety of ASCT in 28 SLE patients from eight centres reported European Group for Blood Marrow...
M2 macrophages are predominant in the immune infiltrates of resected tumours, but little is known about macrophage phenotype local lung cancer environment, which may be evaluated by bronchoalveolar lavage fluid (BALF).To find differences between BALF from affected (clBALF) and hlBALF opposite, healthy lung, as a control, same patient, regarding their individual polarization correlation with IL-10 TGF-β.Eighteen patients confirmed were investigated. Macrophage subtyping was performed...
Regimen-related mucosal toxicity is extremely common following cytotoxic chemotherapy and radiotherapy. Mucositis as an important determinant of the inflammatory response infectious complications in cancer treated patients. Most assessment scales for damage are focussed on oral mucositis, since it easy to evaluate. Measuring gastrointestinal musocal objectively remains difficult because cannot be seen directly or readily detected. One potential non-invasive biomarkers plasma citrulline...
Incidence and outcome of microbiologically documented bacterial/viral infections invasive fungal disease (IFD) in children adults after hematopoietic cell transplantation (HCT) were compared 650 3200 multicenter cross-sectional nationwide study. Infections diagnosed 60.8% 35.0% adults, including respectively 69.1% 63.5% allo-HCT, 33.1% 20.8% auto-HCT patients. The incidence bacterial was higher (36.0% vs 27.6%; p < 0.0001). with Gram-negative bacteria more frequent than Gram-positives (64.6%...
Studying the dynamics changes of neutrophils during innate immune response in coronavirus 2019 (COVID-19) can help understand pathogenesis this disease. The aim study was to assess usefulness new neutrophil activation parameters: Immature Granulocyte (IG), Neutrophil Reactivity Intensity (NEUT-RI), Granularity (NEUT-GI), and data relating granularity, activity, volume (NE-WX, NE-WY, NE-WZ) available hematology analyzers distinguish convalescent patients from with active SARS-CoV-2 infection...
Monocytes play a role in viral biology, but little is known about the monocyte subpopulation course of COVID-19 disease. The aim study was analysis classical, intermediate and non-classical monocytes with expression PD-L1 CD62L, TIM-3 CD86 molecules peripheral blood (PB) to distinguish patients SARS-CoV-2 infection from convalescent patients. group consisted 55 51 cells were analyzed by flow cytometry. number proportion lower than We observed ones. There higher PDL-1-positive noticed...
ABSTRACT Objectives The study evaluated the impact of lifestyle and environmental exposure on etiology multiple myeloma (MM). Methods A multicenter case–control was conducted in 20 hematology centers 5 outpatient clinics Poland. questionnaire to potential risk factors including sociodemographic data, lifestyle, completed. Results total 274 patients with newly diagnosed MM 208 from primary healthcare control group were enrolled study. Regarding sports practiced systematically for at least...
Recent developments in the field of targeted therapy have led to discovery a new drug, plerixafor, that is specific inhibitor CXCR4 receptor. Plerixafor acts concert with granulocyte colony-stimulating factor (G-CSF) increase number stem cells circulating peripheral blood (PB). Therefore, it has been applied hematopoietic cell mobilization. We analyzed retrospectively data regarding mobilization plerixafor cohort 61 patients suffering from multiple myeloma (N = 23), non-Hodgkin's lymphoma...
(1) The cells from the monocyte line play an important role as regulators of cancer development and progression. Monocytes present pro- anti-tumor immunity differentiation into macrophages. Macrophages are predominant in lung environment could be evaluated by bronchoalveolar lavage fluid (BALF). (2) aim study was analysis monocytes: classical, intermediate non-classical with expression of: CD62L, CD11c, CD18, HLA-DR non-small cell (NSCLC) their correlation BALF macrophages lungs (clBALF)...
The presence of metastases in mediastinal lymph nodes (LNs) is essential for planning lung cancer treatment and assessing anticancer immune responses. aim the study was to assess LNs neoplastic cells evaluate cancer-selected antigen expression. LN aspirates were obtained during an EBUS/TBNA procedure. analyzed using a hematological analyzer flow cytometry. It possible indicate characterized by high fluorescence connected with metabolic activity determine their non-hematopoietic origin Using...
Cell response to novel coronavirus disease 19 (COVID-19) is currently a widely researched topic. The assessment of leukocytes population and the maturation both B T lymphocytes may be important in characterizing immunological profile COVID-19 patients. aim present study was evaluate cells patients with interstitial lesions on chest X-ray (COVID-19 (+)), without changes (−)) healthy control. group consisted 23 divided two groups: (+) n = 14 (−) 9 control 20. flow cytometry method performed....
Identification of patients with activation the immune system which indicates presence infection is essential, especially in times global coronavirus 2019 (COVID-19) pandemic. The aim present study was to evaluate reactive lymphocytes (RE-LYMP) parameter COVID-19 and correlate it markers by flow cytometry. group consisted 40 patients: (n = 20) others virus infections without (COVID-19(−) 20)) 20 healthy donors (HC). Blood count cytometry were performed. COVID-19(+) had significantly lower...
The role of the adaptive microenvironment components in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection is widely researched, but remains unclear. Studying common dynamics immune response changes can help understand pathogenesis disease 2019 (COVID-19), especially critical patients. aim present study was to determine cytokines concentration and leukocyte subpopulations profiles COVID-19 (n = 23) 18) group distinguished by computed tomography (CT) severity score. We...
Lymphocytes play a leading role in regulation of the immune system lung cancer patients. The recognition T cells profile may help prediction effectiveness anticancer immunotherapy. aim study was to determine dominant subpopulation CD4+ and CD8+ lymphocytes metastatic non-metastatic lymph nodes (LNs) LNs aspirates were obtained during EBUS/TBNA procedure analyzed by flow cytometry. We showed higher percentage effector memory than (28.6 vs. 15.3% 28.6 14.0%, p&lt; 0.05). proportion CD45RO+...
Myelodysplastic syndromes (MDS) are common malignant disorders with a poor prognosis. It is necessary to search for new rapid diagnostic methods detect MDS patients cytogenetic changes. The aim of the study was assess hematological neutrophil- and monocyte- related parameters I then bone marrow patient without A total 45 MDS, including 17 changes, were examined. conducted using Sysmex XN-Series analyzer. New neutrophil monocyte parameters, such as immature granulocytes (IG), reactivity...
Fragility scales are intended to help in therapeutic decisions. Here, we asked if the fragility assessment MM patients ≥ 75 years old qualified for treatment by local physician correlates with choice of treatment: a two- or three-drug regimens. Between 7/2018 and 12/2019, prospectively enrolled 197 at start from 13 Polish Myeloma Group centers. The data assess were collected, but centrally assessed was not disclosed center. activity daily living (ADL) could be 192 (97.5%) independent 158...