A5070788352- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- Mesenchymal stem cell research
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- Multiple Myeloma Research and Treatments
- T-cell and Retrovirus Studies
- Multiple and Secondary Primary Cancers
- Cutaneous lymphoproliferative disorders research
- Immunodeficiency and Autoimmune Disorders
- CNS Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- CAR-T cell therapy research
- Complement system in diseases
- Hemophilia Treatment and Research
- Childhood Cancer Survivors' Quality of Life
Ministry of Health of the Russian Federation
2016-2024
The University of Texas Health Science Center at Houston
2023
The University of Texas MD Anderson Cancer Center
2023
Children's Hospital Colorado
2023
Astellas Pharma (United States)
2023
University of Kansas Medical Center
2023
National Medical Research Center for Hematology
2010-2023
University of Colorado Denver
2023
National Medical Research Center of Cardiology
2022-2023
Introduction . Immunophenotyping is a key diagnostic method for chronic lymphocytic leukemia (CLL), the most common lymphoproliferative disorder (LPD) in middle-aged and elderly individuals. Given high prevalence of CLL, there need to standardize approaches its immunophenotypic diagnosis, including development standardized panels monoclonal antibodies, recommendations sample preparation, formulation reports improve accuracy. Aim : develop unified laboratory report form approach using...
Introduction. At the initiative of Russian Hematology Society, research group for study idiopathic aplastic anemia has developed clinical recommendations diagnosis and treatment anemia. Aim: to standardize diagnostic therapeutic approaches acquired in Russia. Methods. The methodological used are based on principles evidence-based medicine, council experts patients with anemia, international experience managing patients, European Results. A new revised updated version national guidelines is...
Myelodysplastic syndromes (MDS) can present a challenge for clinicians. Multicolor flow cytometry (MFC) aid in establishing diagnosis. The aim of this study was to determine the optimal MFC approach MDS.The included 102 MDS (39 low-grade MDS), 83 cytopenic patients without myeloid neoplastic disorders (control group), and 35 healthy donors. Bone marrow analyzed using six-color MFC. Analysis conducted according "Ogata score," "Wells integrated (iFC) score.The respective sensitivity...
The article presents a systematic diagnostic approach for thrombocytopenia, as well the results of practical implementation thrombocytopenia protocol in adult patients. Among 183 patients first admitted to HRC with unspecified origin primary immune (ITP) was established only 48 % patients, while 52 cases it symptom another pathology (the ratio 1 : 1). As result re-examination 118 relapse long-term history ITP diagnosis confirmed 85 cases, 15 has been changed different nosology. show that...
Introduction. When establishing a diagnosis of thrombotic thrombocytopenic purpura (TTP) for the first time, other diseases occurring with thrombocytopenia may be misdiagnosed. Aim: to analyze diagnostic difficulties and errors TTP. Materials methods. In total, 54 patients (44 women 10 men) aged 18 83 years (median 33 years), who were diagnosed TTP from 2019 2023, included in study. Anamnesis, baseline hemoglobin, platelets, erythrocytes, lactate dehydrogenase bilirubin serum concentrations,...
Introduction . Disruption of iron utilization by erythrocaryocytes with deposition hemosiderin granules in the form a ring is pathognomonic sign sideroblastic anemia. An integral part diagnosis this type anemia cytomorphological analysis bone marrow aspirate cytochemical reaction to sideroblasts. Aim — present current methods cytological and Main findings A presence sideroblasts marrow. Ring are considered be intramitochondrial located around nucleus. It only possible diagnose using special...
Introduction . Pregnancy is one of the most frequent triggers congenital and acquired forms thrombotic thrombocytopenic purpura (TTP). Aim — to develop tactics for treatment pregnant women with TTP. Results TTP was associated pregnancy in 55.5 % all cases women. In 5 pregnancies which diagnosis known before pregnancy, or established early stages, treated throughout pregnancy. form, plasma transfusions were performed once every two weeks until 20th week weekly, if thrombocytopenia < 150 ×...
Introduction . Recommendations cover the current state of diagnosis and treatment mastocytosis. Aim — а consolidation Russian experts’ opinion on for adult Main findings The recommendations have been developed taking into account foreign literature, national experience world clinical evidence therapy systemic cutaneous mastocytoses, mast cell leukaemia other mastocytosis forms. significance bone marrow peripheral blood molecular genetic testing presence KITD816V gene variants is...
Introduction. Over the past 5 years, signifi cant progress has been achieved in treatment of patients with Ph-negative acute lymphoblastic leukemia (ALL). Treatment results were compared between two protocols Russian multicenter studies «ALL-2009» and «ALL-2016», which multicomponent high-dose consolidation was not used. The principle continuity observed modifi cation doses cytostatic drugs depending on depth cytopenia. Aim – to compare 5-year determine factors unfavorable prognosis ALL....
Aim.To assess the safety and efficacy of autologous haematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM) patients with dialysis-dependent renal failure. Materials methods.During a period from May 2010 to December 2016 fourteen MM failure aged 48 65 years underwent auto-HSCT. After induction therapy complete response, very good partial response were documented 64, 29, 7% patients, respectively. In no case was achieved. Haematopoietic mobilization most (13/14)...
Treatment programs for patients with acquired aplastic anemia include two main therapeutic options: allogeneic bone marrow transplantation and combined immunosuppressive therapy (IST). However, IST remains the method of choice most adult AA patients. This study included 120 who received at National Research Center Hematology in 20072016. The analysis was applied to Median age 25 (1765) years, M/F: 66/54, SAA/NSAA: 66%/34%. Effectiveness carried out AA. group did not 8 SAA died during first 3...
Introduction . Non-chemotherapy for acute promyelocytic leukaemia (APL) with a combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) provides high patient survival rate at lesser toxicity as effectively or superior to standard chemotherapy programmes. Aim — assessment the ATO–ATRA risk-adapted exposure protocol in management de novo leucaemia. Materials methods A prospective study included 51 primary APL patients aged 18–76 years. The program remission induction (ATO 0.15...
Splenic marginal zone B-cell lymphoma (SMZBCL) is a rare non-Hodgkin that presents with morphologically mature lymphoid cells corresponding in their immunological characteristics to secondary follicular lymphocytes. It clinically characterized by splenomegaly, moderate lymphocytosis, usually focal bone marrow lesion, sometimes of monoclonal immunoglobulin the serum (generally IgM or IgG) and/or urea, and relatively benign course. Leishmaniasis transmissible natural infectious endemic disease...
Contex. Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkins lymphoma, characterized by generalized lymphadenopathy, hepatosplenomegaly and dysproteinemia. Hypergammaglobulinaemia revealed in 50-83% pts with AITL. However, the characteristics immunoglobulinopathies observed AITL are scarce. Objective: The aim study was to characterize quantitative qualitative patients at onset disease. Patients methods. 55 newly diagnosed were enrolled study, male/female ratio 30/25;...
Background. Current chemotherapy protocols for T-cell acute lymphoblastic leukemia (T-ALL) allow achieving a 5-year overall survival of 60–90 %, but relapsed and refractory forms remain incurable situations. Aim. To determine the significance immunophenotypic, cytogenetic molecular markers in adult T-ALL patients receiving therapy according to ALL-2016 protocol. Materials methods. From December 2016 June 2022, 113 with primary were included study. Cytogenetic study was performed 104 (92 %)...
Acute promyelocytic leukemia (APL) is a blood tumor characterized by aggressive clinical progression with characteristic and laboratory signs (typical cell morphology, severe hemorrhagic syndrome, hemorrhages hematoma formation, excessive fibrinolysis, disseminated intravascular coagulation syndrome) but modern approaches to therapy potentially make this disease fully curable. APL considered one of the most studied subtypes acute abnormal proliferation promyelocytes in bone marrow. The...
Introduction. The use of invasive methods for diagnosing primary diffuse large B-cell lymphoma the central nervous system (PDLBCL CNS) and vitreoretinal (PVRL) is often associated with development severe neurological deficits disability patients. A promising direction in diagnosis PDLBCL CNS PVRL non-invasive approaches based on molecular genetic determination mutations MYD88 gene cerebrospinal fluid (CSF), vitreous (VF) free circulating tumor DNA (cfDNA) blood serum. Aim: to present...
Aim. To analyze the efficiency and reproducibility of ALL-2009 protocol within Russian prospective multicenter study based on different principles cytostatic effects (non-intensive, but continuous cytotoxic treatment a small number allogeneic hematopoietic stem cells). Subjects methods. The (NCT01193933) conducted in April 2009 to December 2016 included 194 patients (95 males 99 females) aged 15 55 years (median age 28 years) with Ph-negative B-cell acute lymphoblastic leukemia (ALL). There...
Aim. To analyze the frequency and nature of hemorrhagic thrombotic complications in patients with systemic AL-amyloidosis compare laboratory changes hemostasis system. Materials methods. The prospective study included 40 newly diagnosed AL-amyloidosis. detect amyloid, all underwent bone marrow trephine biopsy duodenal biopsy, 28 (70%) affected organ. Before start therapy, were determined platelet count, activated partial thromboplastin time, thrombin fibrinogen concentration, time...
Background. Vascular endothelial growth factor A (VEGFA) is one of the most important factors for regulation hematopoietic stem cells differentiation. It involved in leukemogenesis and central nervous system (CNS) damage acute leukemia. According to literature, VEGFA production by blast increased, but values serum concentration associations with CNS involvement are contradictory. Aim. evaluate VEGFA, VEGFR1, VEGFR2 cerebrospinal fluid patient different types leukemia disease onset during...