A5025914506- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Blood groups and transfusion
- Organ Transplantation Techniques and Outcomes
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Immunodeficiency and Autoimmune Disorders
- Liver physiology and pathology
- Hematopoietic Stem Cell Transplantation
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Pediatric health and respiratory diseases
- T-cell and B-cell Immunology
- Respiratory viral infections research
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- Liver Diseases and Immunity
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
Russian Medical Academy of Continuous Professional Education
2012-2025
Ministry of Health of the Russian Federation
2015-2024
Ministry of Health
2021
Saratov State Medical University
2018
State Research Center of the Russian Federation
2011
Tufts University
2011
Introduction . Immunophenotyping is a key diagnostic method for chronic lymphocytic leukemia (CLL), the most common lymphoproliferative disorder (LPD) in middle-aged and elderly individuals. Given high prevalence of CLL, there need to standardize approaches its immunophenotypic diagnosis, including development standardized panels monoclonal antibodies, recommendations sample preparation, formulation reports improve accuracy. Aim : develop unified laboratory report form approach using...
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder characterized by partial or absolute deficiency of glycophosphatidyl-inositol (GPI) anchor-linked surface proteins on blood cells. A lack precise diagnostic standards for flow cytometry has hampered useful comparisons data between laboratories. We report from the first study evaluating reproducibility high-sensitivity PNH in Russia.PNH clone sizes were determined at diagnosis patients a central laboratory and...
We describe an application of a cell-binding microarray – to parallel study morphology, tartrate-resistant acid phosphatase activity and detection surface markers on peripheral blood lymphocytes 90 atients with suspected hairy cell leukemia (HCL). have formulated the microarray-based diagnostic criteria for leukemia, variant (HCLv) splenic marginal zone lymphoma (SMZL). According these we suggested presence HCL 55 patients, HCLv 7 patients SMZL 10 from studied cohort. These diagnoses were...
It has been proposed that circulating HSCs play a role in graft survival after liver transplantation. The aim was to analyze the relationship between number of before and LDLT function, immune biomarkers, clinical outcomes pediatric patients. We studied 15 pairs adult healthy donors recipients with ESLD. CD34/CD45+ cell measured blood via flow cytometry, plasma levels biomarkers - ELISA. decreased within first week LDLT. negatively correlated CRP development dysfunction early post-transplant...
We have studied the morphology and immunophenotype of circulating tumor cells isolated from peripheral blood 22 patients with splenic marginal zone lymphoma show that both them are highly heterogeneous. Using a cell-binding microarray we demonstrated positive for CD19 (100 %), CD20 CD22 surface IgM (73 CD38 (23 CD5 (9 CD11c (36 CD103 (5 CD25 (32 CD23 %) these immunophenotypes confirmed in all cases by flow cytometry. Higher density lymphocyte binding onto anti-CD antibody spots compared to...
Comparative analysis of the results clinical-laboratory and instrumental data from 379 patients hospitalized during 2009—2016, with influenza complicated pneumonia, showed that most severe lung lesions were statistically significantly more likely to develop in first three days caused by shift changed agent comorbid diseases — chronic heart vessels (in isolation or association other factors). The differences main characteristics pneumonia patterns cytokine responses between survivors deceased...
Background & Aims. This paper presents the results of observational study ibrutinib in patients with chronic lymphocytic leukemia (CLL), conducted SP Botkin Municipal Clinical Hospital. The main objective was analysis complications and identification factors, influencing dosage regimen; secondary estimation total response to treatment, event-free overall survival. Materials Methods. included 96 CLL indications for therapy. median age 64,9 years (range 32-91 years), population consisted...
Aim. To develop reference intervals for white blood cell subpopulations in peripheral using Cytomics FC500 flow cytometer and CytoDiff™ reagent (Beckman Coulter). Materials & Methods. The trial included the analysis of samples healthy donors (n = 315) cocktail composed 6 antibodies 5 colors (CD36-FITC, CD2-PE, CD294-PE, CD19-ECD, CD16-Cy5, CD45-Cy7) enabling to count 17 populations. Results. data obtained by means multicolor cytofluorometry values populations blood. In 1 first-time donor...
ОБВИТИЕ ПУПОВИНЫ И ПЕРИНАТАЛЬНЫЕ ИСХОДЫ В ЗАВИСИМОСТИ ОТ СПОСОБА РОДОРАЗРЕШЕНИЯ ХВОРОСТУХИНА НАТАЛИЯ ФЕДОРОВНА
Background. In view of similar morphological and phenotypic characteristics some B-cell lymphoproliferative diseases despite the known phenotype tumor cells, a search is currently underway for new diagnostic markers, expression which remains stable during chronic lymphocytic leukemia (CLL) treatment can be used both diagnosis assessment residual population. One such markers ROR-1. Aim. To assess feasibility ROR-1 marker using В-lymphocytes in minimal disease (MRD) dynamics monitoring CLL....
The purpose of the study is to identify specifics author's word formation in work E. D. Luchezarnova. article proves that most neologisms within rhythmological concept are based on sound-symbolic phonetic significance, which gives character ornamentation texts as a structural principle text formation. methodology conducted research presented and data psychosemantic experiments semantic differential presented. scientific novelty lies fact comparative analysis results automated audit studies...
Profound immunological dysfunction is the key factor determining development of infectious complications in chronic lymphocytic leukemia (CLL). The aim this work to assess features subpopulation composition T-lymphocytes (T-helpers (Th), cytotoxic (Tcyt), T regulatory cells (Treg), T-NK cells, naive Th, Th-memory, activated T-lymphocytes, TCRγδ cells) and NK peripheral blood patients with newly diagnosed (CLL) receiving ibrutinib therapy. Hematological immunophenotypic studies have been...
Introduction. Optimal therapy for elderly patients with chronic lymphocytic leukemia (CLL) is the subject of intensive research. Aim – to study safety obinutuzumab, as well selection optimal scheme its use in CLL, complicated by diabetes mellitus, renal insuffi ciency, cardiac comorbidity. Materials and methods. The included primary CLL having indications requiring therapy. inclusion criteria were: Cumulative Illness Rating Scale, CIRS) (CIRS) > 6 or glomerular fi ltration rate (GFR) <...
Aim. To determine the relationship between CD34/CD45 positive cells number in peripheral blood before and after heart transplantation (HTx) plasma level of biomarkers. Materials methods. We studied 27 pts. (23 men; 40 ± 13 years) with failure caused by dilated (17 cases) or ischemic cardiomyopathy (10 HTx. were measured 2–4 days operation fl ow cytometry expressed per 10 6 events, biomar- kers – ELISA. Results. The CD34/CD45+ (224 166) was similar to those healthy individuals (233 120) there...