A5018866586- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Neuroblastoma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Mesenchymal stem cell research
- Neutropenia and Cancer Infections
- Neonatal Respiratory Health Research
- Cancer Genomics and Diagnostics
- Blood disorders and treatments
- Sarcoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- Reproductive Biology and Fertility
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Central Venous Catheters and Hemodialysis
- CAR-T cell therapy research
Schneider Children's Medical Center
2016-2025
Tel Aviv University
2015-2024
Rabin Medical Center
2001-2018
Finnish Red Cross
2016
Canadian Blood Services
2016
Singapore General Hospital
2016
Europdonor Foundation
2016
National Marrow Donor Program
2016
Hadassah Medical Center
2013
University Medical Center
2013
Total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is efficacious, but long-term side effects are concerning. We investigated whether preparative combination chemotherapy could replace TBI such patients.FORUM a randomized, controlled, open-label, international, multicenter, phase III, noninferiority study. Patients ≤ 18 years at diagnosis, 4-21 HSCT, complete remission pre-HSCT, and an...
Background. Burnout, a syndrome of emotional exhaustion, depersonalization, and diminished feelings accomplishment, is common among pediatric oncology staff. This study explores mindfulness-based course (MBC) to decrease burnout in multidisciplinary group staff members the United States Israel. Materials methods. Forty-eight participants, mostly nurses, were randomized either MBC intervention or control group. participants received eight weekly sessions mindfulness education. The primary...
The inability to generate mesenchymal stromal cells (MSCs) of consistent potency likely is responsible for inconsistent clinical outcomes patients with aGvHD receiving MSC products. We developed a novel manufacturing protocol characterized by high in vitro and near-identity individual doses, referred as "MSC-Frankfurt am Main (MSC-FFM)". Herein, we report the 69 who have received MSC-FFM. These were 51 children 18 adults refractory grade II (4%), III (36%) or IV (59%). Patients either...
Stomatitis is a common consequence of chemotherapy and condition for which there little effective treatment. Although the management patients with other chemotherapy-related toxicities has improved in recent years, incidence stomatitis increasing because more intensive treatment often dose limiting factor chemotherapy. The authors assessed efficacy homeopathic remedy, TRAUMEEL S(R), chemotherapy-induced children undergoing bone marrow transplantation.A randomized, placebo-controlled,...
BACKGROUND Stomatitis is a common consequence of chemotherapy and condition for which there little effective treatment. Although the management patients with other chemotherapy-related toxicities has improved in recent years, incidence stomatitis increasing because more intensive treatment often dose limiting factor chemotherapy. The authors assessed efficacy homeopathic remedy, TRAUMEEL S®, chemotherapy-induced children undergoing bone marrow transplantation. METHODS A randomized,...
Abstract Regulation of the actin cytoskeleton is crucial for normal development and function immune system, as evidenced by severe abnormalities exhibited patients bearing inactivating mutations in Wiskott–Aldrich syndrome protein (WASP), a key regulator dynamics. WASP exerts its effects on dynamics through multisubunit complex termed Arp2/3. Despite critical role played Arp2/3 an effector WASP-mediated control over polymerization, components had not previously been identified cause...
The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting cell antigen receptor triggering to downstream responses. In this study, we describe the first kindred with defective LAT caused by homozygous mutation in exon 5, leading premature stop codon deleting most cytoplasmic tail LAT, including tyrosine residues signal propagation. three patients presented from early childhood combined immunodeficiency and severe autoimmune disease. Unlike mouse...
(1) Background: Refractory acute graft-versus-host disease (R-aGvHD) remains a leading cause of death after allogeneic stem cell transplantation. Survival rates 15% four years are currently achieved; deaths only in part due to aGvHD itself, but mostly adverse effects R-aGvHD treatment with immunosuppressive agents as these predispose patients opportunistic infections and loss graft-versus-leukemia surveillance resulting relapse. Mesenchymal stromal cells (MSC) from different tissues those...
Specific protocols define eligibility, conditioning, donor selection, graft composition and prophylaxis of vs. host disease for children young adults undergoing hematopoietic stem cell transplant (HSCT). However, international rarely, if ever, detail supportive care, including pharmaceutical infection prophylaxis, physical protection with face masks cohort isolation or food restrictions. Supportive care suffers from a lack scientific evidence implementation practices in the centers brings...
Dipeptidyl peptidase 9 (DPP9) is a direct inhibitor of NLRP1, but how it affects inflammasome regulation in vivo not yet established. Here, we report three families with immune-associated defects, poor growth, pancytopenia, and skin pigmentation abnormalities that segregate biallelic
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In the mid-1990s, we introduced a fludarabine (Flu)-based conditioning regimen for hematopoietic stem cell transplantation (HSCT) in patients with Fanconi anemia (FA).The aim of this study is to compare Flu-based alternative regimens FA. Forty-one FA (aged 0.5-31, median, 10.3 years) who underwent allogeneic HSCT were included retrospective study. Hospital records reviewed regimens, engraftment data, and toxicity. The median (range) follow-up was 32 (0.5-149) months. used 24 patients: 17...