NFDI4DS | UHH-SEMS - Publication Details

Andreas E. Kulozik

ORCID: 0000-0003-1953-0848

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A5031617518

Research Areas

Hemoglobinopathies and Related Disorders
Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
Epigenetics and DNA Methylation
RNA modifications and cancer
RNA Research and Splicing
Glioma Diagnosis and Treatment
RNA and protein synthesis mechanisms
CAR-T cell therapy research
Iron Metabolism and Disorders
Childhood Cancer Survivors' Quality of Life
Blood groups and transfusion
Radiation Therapy and Dosimetry
Cancer Genomics and Diagnostics
Sarcoma Diagnosis and Treatment
Erythrocyte Function and Pathophysiology
Chronic Myeloid Leukemia Treatments
Neonatal Health and Biochemistry
Blood Coagulation and Thrombosis Mechanisms
Hedgehog Signaling Pathway Studies
Chromatin Remodeling and Cancer
Histone Deacetylase Inhibitors Research
Neuroblastoma Research and Treatments
Lymphoma Diagnosis and Treatment
Testicular diseases and treatments

Heidelberg University
2016-2025

University Hospital Heidelberg
2016-2025

German Cancer Research Center
2011-2024

European Molecular Biology Laboratory
2014-2024

Hopp Children's Cancer Center Heidelberg
2010-2024

European Molecular Biology Organization
2007-2024

Heidelberg University
2008-2024

German Marine Research Consortium
2017-2024

Nierenzentrum Heidelberg
2023

National Center for Tumor Diseases
2016-2022

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

OPENALEX - Publications

Jeremy Schwartzentruber Andrey Korshunov Xiao-Yang Liu David Jones Elke Pfaff and 57 more

10.1038/nature10833 article EN Nature 2012-01-27

DNA methylation-based classification of central nervous system tumours

OPENALEX - Publications

David Capper David Jones Martin Sill Volker Hovestadt Daniel Schrimpf and 95 more

10.1038/nature26000 article EN Nature 2018-03-13

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

OPENALEX - Publications

Dominik Sturm Hendrik Witt Volker Hovestadt Dong-Anh Khuong-Quang David Jones and 73 more

10.1016/j.ccr.2012.08.024 article EN publisher-specific-oa Cancer Cell 2012-10-01

The landscape of genomic alterations across childhood cancers

OPENALEX - Publications

Susanne Gröbner Barbara C. Worst Joachim Weischenfeldt Ivo Buchhalter Kortine Kleinheinz and 79 more

Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into biology. Here we present comprehensive analysis of genetic alterations in pan-cancer cohort including 961 tumours from children, adolescents, young adults, comprising 24 distinct molecular cancer. Using standardized workflow, identified marked terms mutation frequency significantly mutated genes comparison previously analysed adult cancers....

10.1038/nature25480 article EN cc-by Nature 2018-02-28

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

OPENALEX - Publications

Kristian W. Pajtler Hendrik Witt Martin Sill David Jones Volker Hovestadt and 51 more

10.1016/j.ccell.2015.04.002 article EN publisher-specific-oa Cancer Cell 2015-05-01

Dissecting the genomic complexity underlying medulloblastoma

OPENALEX - Publications

David Jones Natalie Jäger Marcel Kool Thomas Zichner Barbara Hutter and 85 more

Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of samples authors show that clinically challenging Group 3 and 4 tumours can be tetraploid, reveal expression first medulloblastoma fusion genes identified. malignant children. Four papers published 2 August 2012 issue Nature use other techniques to produce a detailed picture genetics genomics this condition. Notable findings include identification recurrent mutations not previously implicated...

10.1038/nature11284 article EN cc-by-nc-sa Nature 2012-07-24

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

OPENALEX - Publications

Tobias Rausch David Jones Marc Zapatka Adrian M. Stütz Thomas Zichner and 46 more

10.1016/j.cell.2011.12.013 article EN publisher-specific-oa Cell 2012-01-01

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

OPENALEX - Publications

David Jones Barbara Hutter Natalie Jäger Andrey Korshunov Marcel Kool and 69 more

10.1038/ng.2682 article EN Nature Genetics 2013-06-30

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

OPENALEX - Publications

Marcel Kool David Jones Natalie Jäger Paul A. Northcott Trevor J. Pugh and 71 more

10.1016/j.ccr.2014.02.004 article EN publisher-specific-oa Cancer Cell 2014-03-01

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

OPENALEX - Publications

Paul A. Northcott Catherine Lee Thomas Zichner Adrian M. Stütz Serap Erkek and 74 more

10.1038/nature13379 article EN Nature 2014-06-20

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

OPENALEX - Publications

Stephen C. Mack Hendrik Witt Rosario M. Piro Lei Gu Scott Zuyderduyn and 84 more

10.1038/nature13108 article EN Nature 2014-02-01

Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

OPENALEX - Publications

Hendrik Witt Stephen C. Mack Marina Ryzhova Sebastian Bender Martin Sill and 31 more

10.1016/j.ccr.2011.07.007 article EN publisher-specific-oa Cancer Cell 2011-08-01

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

OPENALEX - Publications

Stefan M. Pfister Wibke G. Janzarik Marc Remke Aurélie Ernst Wiebke Werft and 18 more

The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors, we performed a genome-wide analysis DNA copy number aberrations in low-grade by using array-based comparative genomic hybridization. Duplication BRAF protooncogene was most frequent aberration, and tumors duplication showed significantly increased mRNA levels downstream target, CCND1, as compared without duplication. Furthermore,...

10.1172/jci33656 article EN Journal of Clinical Investigation 2008-04-15

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

OPENALEX - Publications

Pascal D. Johann Serap Erkek Marc Zapatka Kornelius Kerl Ivo Buchhalter and 53 more

10.1016/j.ccell.2016.02.001 article EN publisher-specific-oa Cancer Cell 2016-02-25

A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA)

OPENALEX - Publications

M. Castoldi Sabine Schmidt Vladimı́r Beneš Mikkel Noerholm Andreas E. Kulozik and 2 more

MicroRNAs represent a class of short (∼22 nt), noncoding regulatory RNAs involved in development, differentiation, and metabolism. We describe novel microarray platform for genome-wide profiling mature miRNAs (miChip) using locked nucleic acid (LNA)-modified capture probes. The biophysical properties LNA were exploited to design probe sets uniform, high-affinity hybridizations yielding highly accurate signals able discriminate between single nucleotide differences and, hence, closely related...

10.1261/rna.2332406 article EN RNA 2006-03-15

Binary specification of nonsense codons by splicing and cytoplasmic translation

OPENALEX - Publications

Rolf Thermann Gabriele Neu‐Yilik Andrea Deters Ute Frede Kristina Wehr and 3 more

10.1093/emboj/17.12.3484 article EN The EMBO Journal 1998-06-15

Sarcoma classification by DNA methylation profiling

OPENALEX - Publications

Christian Koelsche Daniel Schrimpf Damian Stichel Martin Sill Felix Sahm and 95 more

Abstract Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents children. They represent a morphologically heterogeneous class of some entities lack defining histopathological features. Therefore, the diagnosis sarcomas is burdened with high inter-observer variability misclassification rate. Here, we demonstrate classification using machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma trained dataset 1077 profiles from...

10.1038/s41467-020-20603-4 article EN cc-by Nature Communications 2021-01-21

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias

OPENALEX - Publications

Chen Shochat Noa Tal Obul Reddy Bandapalli Chiara Palmi Ithamar Ganmore and 11 more

Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined immune deficiency. Here, we describe somatic gain-of-function IL7R pediatric B and T acute lymphoblastic leukemias. The either a serine-to-cysteine substitution at amino acid 185 the extracellular domain (4 patients) or in-frame insertions deletions transmembrane (35 patients). In cell precursor leukemias, were associated with aberrant...

10.1084/jem.20110580 article EN The Journal of Experimental Medicine 2011-05-02

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

OPENALEX - Publications

Andrey Korshunov Marina Ryzhova Volker Hovestadt Sebastian Bender Dominik Sturm and 16 more

10.1007/s00401-015-1405-4 article EN Acta Neuropathologica 2015-03-09

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

OPENALEX - Publications

Michal Kováč Claudia Blattmann Sebastian Ribi Jan Smida Nikola S. Mueller and 22 more

Abstract Osteosarcomas are aggressive bone tumours with a high degree of genetic heterogeneity, which has historically complicated driver gene discovery. Here we sequence exomes 31 and decipher their evolutionary landscape by inferring clonality the individual mutation events. Exome findings interpreted in context SNP array data from replication set 92 tumours. We identify 14 genes as main drivers, some were formerly unknown osteosarcoma. None drivers is clearly responsible for majority even...

10.1038/ncomms9940 article EN cc-by Nature Communications 2015-12-03

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

OPENALEX - Publications

Pavel Ivanov Niels H. Gehring Joachim B. Kunz Matthias W. Hentze Andreas E. Kulozik

10.1038/emboj.2008.17 article EN The EMBO Journal 2008-02-07

Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study

OPENALEX - Publications

Barbara C. Worst Cornelis M. van Tilburg Gnana Prakash Balasubramanian Petra Fiesel Ruth Witt and 50 more

10.1016/j.ejca.2016.06.009 article EN European Journal of Cancer 2016-07-29

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