A5023573690- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Mathematical Biology Tumor Growth
- Ferroptosis and cancer prognosis
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neuropharmacology Research
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury and Neurovascular Disturbances
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Pituitary Gland Disorders and Treatments
- Extracellular vesicles in disease
Rigshospitalet
2016-2024
University of Copenhagen
1997-2024
Copenhagen University Hospital
2016-2024
Odense University Hospital
2015-2024
University of Southern Denmark
2015-2024
Thermo Fisher Scientific (Denmark)
2017-2023
University Hospital of North Norway
2023
Karolinska Institutet
2021-2022
Kongsberg Innovasjon (Norway)
2013-2021
Aalborg University
2011-2019
Abstract Shifting the balance away from tumor-mediated immune suppression toward tumor rejection is conceptual foundation for a variety of immunotherapy efforts currently being tested. These largely focus on activating antitumor responses but are confounded by multiple cell populations, including myeloid-derived suppressor cells (MDSCs), which serve to suppress system function. We have identified immune-suppressive MDSCs in brains GBM patients and found that they were close proximity...
Glioblastomas are highly aggressive and treatment resistant. Increasing evidence suggests that tumour-associated macrophages/microglia (TAMs) facilitate tumour progression by acquiring a M2-like phenotype. Our objective was to investigate the prognostic value of TAMs in gliomas using automated quantitative double immunofluorescence.Samples from 240 patients with primary glioma were stained antibodies against ionized calcium-binding adaptor molecule-1 (IBA-1) cluster differentiation 204...
Abstract Myeloid-derived suppressor cells (MDSC) that block antitumor immunity are elevated in glioblastoma (GBM) patient blood and tumors. However, the distinct contributions of monocytic (mMDSC) versus granulocytic (gMDSC) subsets have yet to be determined. In mouse models GBM, we observed mMDSCs were enriched male tumors, whereas gMDSCs females. Depletion extended survival only female mice. Using gene-expression signatures coupled with network medicine analysis, demonstrated preclinical...
Glioblastoma (GBM) remains uniformly lethal, and despite a large accumulation of immune cells in the microenvironment, there is limited antitumor response. To overcome these challenges, comprehensive understanding GBM systemic response during disease progression required. Here, we integrated multiparameter flow cytometry mass TOF (CyTOF) analysis patient blood to determine changes system among tumor types over progression. Utilizing cohort 259 patients ranging from benign malignant primary...
Abstract In the 5th edition of WHO CNS tumor classification (CNS5, 2021), multiple molecular characteristics became essential diagnostic criteria for many additional types. For those tumors, an integrated, “histomolecular” diagnosis is required. A variety approaches exists determining status underlying markers. The present guideline focuses on methods that can be used assessment currently most informative and prognostic markers gliomas, glioneuronal neuronal tumors. main are systematically...
Background and Purpose The aim of this study was to conduct a population-based epidemiological survey among young adults aged 18 44 years in Northern Sweden furthermore gain further insight into the etiology ischemic stroke age group. Methods Two studies were done. In first part, data collected calculate incidence mortality from 1991 through 1994. This based on World Health Organization MONICA register acute events. Eighty-eight first-ever patients identified during that period. second 107...
Idiopathic normal pressure hydrocephalus (INPH) is a syndrome of ventriculomegaly, gait impairment, cognitive decline and incontinence that occurs in an elderly population prone to many types comorbidities. Identification the comorbidities thus important part clinical management INPH patients. In 2011, task force was appointed by International Society for Hydrocephalus Cerebrospinal Fluid Disorders (ISHCSF) with objective compile evidence-based expert analysis what we know need regarding...
<b>Objective: </b> To describe cognitive functions and functional outcome in young patients with isolated infratentorial infarcts. <b>Background: Contemporary knowledge implies a cerebellar contribution to behavior. Neuropsychological examination of selective lesions provides an opportunity document the existence nature clinically relevant manifestations from cerebellum. <b>Methods: Prospective case series. The were assessed acutely at 4 12 months after onset. Twenty-four consecutive series...
Abstract Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among microenvironments within a tumor. Metabolic targeting has long been advocated as therapy against many tumors including GBM, but how lipid metabolism is altered to suit different microenvironmental conditions whether cancer stem cells (CSCs) have are outstanding questions in the field. We interrogated gene expression separate of GBM organoid models mimic transition between nutrient-rich...
Abstract Aims Methylation profiling (MP) is increasingly incorporated in the diagnostic process of central nervous system (CNS) tumours at our centres The Netherlands and Scandinavia. We aimed to identify benefits challenges MP as a support tool for CNS tumour diagnostics. Methods About 502 samples were analysed using (850 k) MP. Profiles matched with DKFZ/Heidelberg Tumour Classifier. For each case, final pathological diagnosis was compared before Results In 54.4% (273/502) all cases,...
Abstract Preclinical and clinical proof-of-concept studies have suggested the effectiveness of pharmacological modulation inflammatory cytokines in ischemic stroke. Experimental evidence shows that targeting tumor necrosis factor (TNF) interleukin (IL)-1 holds promise, these are considered prime targets development new stroke therapies. So far, however, information on cellular expression TNF IL-1 human brain is sparse. We studied 14 cases post-mortem stroke, representing 21 specimens...
Glioblastomas are highly resistant to therapy, and virtually all patients experience tumor recurrence after standard-of-care treatment. Surgical resection is a cornerstone in glioblastoma but its impact on cellular phenotypes the local postsurgical microenvironment has yet be fully elucidated.We developed preclinical orthotopic xenograft model rats with integrated 18F-FET PET/CT imaging. Primary recurrent tumors were subject bulk single-cell RNA sequencing. Differentially expressed genes...