Roland Coras
A5043800397- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Meningioma and schwannoma management
- Advanced Neuroimaging Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Genomics and Rare Diseases
- Tuberous Sclerosis Complex Research
- Memory and Neural Mechanisms
- Cerebrospinal fluid and hydrocephalus
- RNA regulation and disease
- Neonatal and fetal brain pathology
- Bone Tumor Diagnosis and Treatments
- Vascular Malformations Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- MicroRNA in disease regulation
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- COVID-19 Clinical Research Studies
- EEG and Brain-Computer Interfaces
- Autoimmune Neurological Disorders and Treatments
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2016-2025
Comprehensive Cancer Center Erlangen
2022-2024
Stichting Epilepsie Instellingen Nederland
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
University Medical Center Utrecht
2024
RWTH Aachen University
2022
Fondazione IRCCS Istituto Neurologico Carlo Besta
2022
Universitätsklinikum Gießen und Marburg
2021
Hippocampal sclerosis (HS) is the most frequent histopathology encountered in patients with drug-resistant temporal lobe epilepsy (TLE). Over past decades, various attempts have been made to classify specific patterns of hippocampal neuronal cell loss and correlate subtypes postsurgical outcome. However, no international consensus about definitions terminology has achieved. A task force reviewed previous classification schemes proposes a system based on semiquantitative that can be applied...
Abstract Ongoing challenges in diagnosing focal cortical dysplasia (FCD) mandate continuous research and consensus agreement to improve disease definition classification. An International League Against Epilepsy (ILAE) Task Force (TF) reviewed the FCD classification of 2011 identify existing gaps provide a timely update. The following methodology was applied achieve this goal: survey published literature indexed with ((Focal Cortical Dysplasia) AND (epilepsy)) between 01/01/2012 06/30/2021 (...
Abstract Focal malformations of cortical development (MCD) are linked to somatic brain mutations occurring during neurodevelopment. Mild malformation with oligodendroglial hyperplasia in epilepsy (MOGHE) is a newly recognized clinico-pathological entity associated pediatric drug-resistant focal epilepsy, and amenable neurosurgical treatment. MOGHE histopathologically characterized by clusters increased cell densities, patchy zones hypomyelination, heterotopic neurons the white matter. The...
Epilepsy is a frequent neurological disorder, although onset and progression of seizures remain difficult to predict in affected patients, irrespective their epileptogenic condition. Previous studies animal models as well human epileptic brain tissue revealed remarkably diverse pattern gene expression implicating epigenetic changes contribute disease progression. Here we mapped for the first time global DNA methylation patterns chronic rats controls. Using methyl-CpG capture associated with...
To clarify the anatomical organization of human memory remains a major challenge in clinical neuroscience. Experimental data suggest dentate gyrus granule cells play role acquisition, i.e. pattern separation and rapid completion, whereas hippocampal CA1 neurons are implicated place autobiographical retrieval. Patients with temporal lobe epilepsy present broad spectrum impairment, which can be assessed during examination. Although long seizure histories may contribute to pathophysiological...
The hippocampal dentate gyrus maintains its capacity to generate new neurons throughout life. In animal models, neurogenesis is increased by cognitive tasks, and experimental ablation of disrupts specific modalities learning memory. humans, the impact on cognition remains unclear. Here, we assessed neurogenic potential in human isolating adult neural stem cells from 23 surgical en bloc hippocampus resections. After proliferation progenitor cell pool vitro identified two distinct patterns....
Abstract As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood–brain barrier and altered neuronal activity, might lead to structural functional rejuvenation the aged brain. Here we show a 6-week treatment young (4 months) old (20 rats montelukast, marketed...
The histopathological spectrum of human epileptogenic brain lesions is widespread including common and rare variants cortical malformations. However, 2-26% epilepsy surgery specimens are histopathologically classified as nonlesional. We hypothesized that these include also new diagnostic entities, in particular when presurgical magnetic resonance imaging (MRI) can identify abnormal signal intensities within the anatomical region seizure onset. In our series 1381 en bloc resected specimens,...
Abstract Objective Ultra‐high‐field 7‐Tesla (7T) magnetic resonance imaging (MRI) offers increased signal‐to‐noise and contrast‐to‐noise ratios, which may improve visualization of cortical malformations. We aim to assess the clinical value in vivo structural 7T MRI its post‐processing for noninvasive identification epileptic brain lesions patients with pharmacoresistant epilepsy nonlesional 3T who are undergoing presurgical evaluation. Methods Sixty‐seven were included had by official...
Abstract Objective Focal cortical dysplasia (FCD) is a major cause of difficult‐to‐treat epilepsy in children and young adults, the diagnosis currently based on microscopic review surgical brain tissue using International League Against Epilepsy classification scheme 2011. We developed an iterative histopathological agreement trial with genetic testing to identify areas diagnostic challenges this widely used scheme. Methods Four web‐based digital pathology trials were completed by 20...
Autopsies are an important tool in medicine, dissecting disease pathophysiology and causes of death. In COVID-19, autopsies revealed e.g., the effects on pulmonary (micro)vasculature or nervous system, systemic viral spread, interplay with immune system. To facilitate multicentre autopsy-based studies provide a central hub supporting autopsy centres, researchers, data analyses reporting, April 2020 German COVID-19 Autopsy Registry (DeRegCOVID) was launched. The electronic registry uses...
Understanding the exact molecular mechanisms involved in aetiology of epileptogenic pathologies with or without tumour activity is essential for improving treatment drug-resistant focal epilepsy. Here, we characterize landscape somatic genetic variants resected brain specimens from 474 individuals epilepsy using deep whole-exome sequencing (>350×) and whole-genome genotyping. Across exome, observe a greater number single-nucleotide low-grade epilepsy-associated tumours (7.92 ± 5.65 variants)...
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared lesional patients. In this study, we aimed to characterize large group patients who underwent despite normal and had no lesion histopathology. Determinants their postoperative seizure outcomes were further studied.
Histone deacetylase inhibitors (HDACi) are potential candidates for therapeutic approaches in cancer and neurodegenerative diseases such as spinal muscular atrophy (SMA)--a common autosomal recessive disorder frequent cause of early childhood death. SMA is caused by homozygous absence SMN1. Importantly, all patients carry a nearly identical copy gene, SMN2, that produces only minor levels correctly spliced full-length transcripts SMN protein. Since an increased number SMN2 copies strongly...
Summary Objective To report on six patients with SCN 1A mutations and malformations of cortical development ( MCD s) describe their clinical course, genetic findings, electrographic, imaging, neuropathologic features. Methods Through our database epileptic encephalopathies, we identified 120 mutations, which 4 had magnetic resonance imaging MRI) evidence s. We collected two further similar observations through the European Task‐force for Epilepsy Surgery in Children. Results The study group...