A5018669927- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Neonatal and fetal brain pathology
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Memory and Neural Mechanisms
- Heart Rate Variability and Autonomic Control
- Fetal and Pediatric Neurological Disorders
- Cannabis and Cannabinoid Research
- Visual perception and processing mechanisms
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Photoreceptor and optogenetics research
- Attention Deficit Hyperactivity Disorder
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
Centre National de la Recherche Scientifique
2016-2025
Inserm
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Hospices Civils de Lyon
2016-2025
Centre de Recherche en Neurosciences de Lyon
2016-2025
Hôpital Pierre Wertheimer
2012-2025
Centre Hospitalier Le Vinatier
2014-2024
Stichting Epilepsie Instellingen Nederland
2024
University of Amsterdam
2024
Amsterdam Neuroscience
2024
Alzheimer's disease is associated with an increased risk of unprovoked seizures. However, the underlying mechanisms seizure induction remain elusive. Here, we performed video-EEG recordings in mice carrying mutant human APPswe and PS1dE9 genes (APdE9 mice) their wild-type littermates to determine prevalence In two recording episodes at onset amyloid beta (Abeta) pathogenesis (3 4.5 months age), least one was detected 65% APdE9 mice, which 46% had multiple seizures 38% a generalized seizure....
Abstract See Engel (doi:10.1093/awv374) for a scientific commentary on this article. Reasons failed temporal lobe epilepsy surgery remain unclear. Temporal plus epilepsy, characterized by primary epileptogenic zone extending to neighboured regions, might account yet unknown proportion of these failures. In study all patients from two programmes who fulfilled the following criteria were included: (i) operated an anterior lobectomy or disconnection between January 1990 and December 2001; (ii)...
Importance It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with by mapping these could inform prognosis and guide interventions. Objective To assess whether lesion map to specific networks. Design, Setting, Participants This case-control study used location network identify a discovery data set of patients poststroke control stroke. Patients stroke (n = 76) no 625) were included. Generalizability other...
To report three patients with drug-resistant nocturnal hypermotor seizures (NHSs), no detectable brain lesion, and clinically defined frontal lobe epilepsy (NFLE) or autosomal dominant NLFE (ADNFLE), whose intracerebral EEG ictal onset primarily involved the insula, rather than mesial orbital cortex. Fourteen to 15 electrodes were implanted in each patient, sampling lobes 80 91 recording leads covering most likely side of seizure onset, two six placed within ipsilateral insula. Electrical...
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
Stereo electroencephalography (SEEG)-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) has been proposed since 2004 as a possible treatment of some focal drug-resistant epilepsy. The aim this study is to provide extensive data about efficacy and safety SEEG-guided RF-TC.Over 10-year period, 162 patients with epilepsy were eligible for RF-TG during phase II invasive investigation by SEEG. All follow-up collected prospectively. primary outcome was seizure freedom at 2 months 1 year...
Abstract Despite numerous studies suggesting the role of insular cortex in control autonomic activity, exact location cardiac motor regions remains controversial. We provide here a functional mapping responses to intracortical stimulations human insula. The effects 100 electrical into 47 epileptic patients were divided tachycardia, bradycardia, and no response according magnitude RR interval (RRI) reactivity. Sympathetic (low frequency , LF, low high powers ratio, LF/HF ratio)...
<h3>Objective:</h3> To identify the clinical determinants of occurrence postictal generalized EEG suppression (PGES) after convulsive seizures (GCS). <h3>Methods:</h3> We reviewed video-EEG recordings 417 patients included in REPO<sub>2</sub>MSE study, a multicenter prospective cohort study with drug-resistant focal epilepsy. According to ictal semiology, we classified GCS into 3 types: tonic-clonic bilateral and symmetric tonic arm extension (type 1), clonic without or flexion 2),...
In patients with pharmaco-resistant focal epilepsies investigated intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. 2013, we proposed new probabilistic functional tractography methodology study human We have now been revisiting this method the F-TRACT project (f-tract.eu) by developing multicenter CCEP...
Everyday life often requires arbitrating between pursuing an ongoing action plan by possibly adjusting it versus exploring a new instead. Resolving this so-called exploitation-exploration dilemma involves the medial prefrontal cortex (mPFC). Using human intracranial electrophysiological recordings, we discovered that neural activity in ventral mPFC infers and tracks reliability of to proactively encode upcoming outcomes as either learning signals or potential triggers explore plans. By...
Recent advances in the field of artificial intelligence have revealed principles about neural processing, particular vision. Previous work demonstrated a direct correspondence between hierarchy human visual areas and layers deep convolutional networks (DCNN) trained on object recognition. We use DCNN to investigate which frequency bands correlate with feature transformations increasing complexity along ventral pathway. By capitalizing intracranial depth recordings from 100 patients we assess...
While Deep Learning (DL) is often considered the state-of-the art for Artificial Intel-ligence-based medical decision support, it remains sparsely implemented in clinical practice and poorly trusted by clinicians due to insufficient interpretability of neural network models. We have approached this issue context online detection epileptic seizures developing a DL model from EEG signals, associating certain properties behavior with expert knowledge. This has conditioned preparation input...
Abstract Whether maximizing rewards and minimizing punishments rely on distinct brain systems remains debated, given inconsistent results coming from human neuroimaging animal electrophysiology studies. Bridging the gap across techniques, we recorded intracerebral activity twenty participants while they performed an instrumental learning task. We found that both reward punishment prediction errors (PE), estimated computational modeling of choice behavior, correlate positively with broadband...