A5104622792- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Metabolism and Genetic Disorders
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Vascular Malformations Diagnosis and Treatment
- Virology and Viral Diseases
- Neurological disorders and treatments
- Autoimmune Neurological Disorders and Treatments
- Neurobiology of Language and Bilingualism
- Fetal and Pediatric Neurological Disorders
- Gastroesophageal reflux and treatments
- Syphilis Diagnosis and Treatment
- Genomics and Rare Diseases
- Glycogen Storage Diseases and Myoclonus
- Meningioma and schwannoma management
- Psychosomatic Disorders and Their Treatments
- Ion channel regulation and function
- Herpesvirus Infections and Treatments
- Mitochondrial Function and Pathology
- Fibroblast Growth Factor Research
University Hospital St. Ivan Rilski
2016-2025
Medical University Plovdiv
2020
University of Gothenburg
2018
University Hospital Bonn
2018
Center for Clinical Research (United States)
2018
Sahlgrenska University Hospital
2018
Multiprofile Hospital for Active Treatment in Neurology and Psychiatry St. Naum
2004-2017
Alexandrovska Hospital
2015
University Radiology
2004
Medical University of Sofia
2001-2002
<h3>Objective</h3> Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. <h3>Methods</h3> Sixteen European centers retrospectively identified cohorts of children adults who underwent epilepsy the period 1997 to 1998 (n = 562) or 2012 2013 736). Data collected included patient (sex, age) disease (duration, localization...
Summary Objective In 2014 the European Union–funded E‐ PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed investigate current use of neuroimaging, electromagnetic source localization, imaging postprocessing procedures in participating centers. Methods A survey on clinical imaging, methods candidates distributed among 25 centers consortium. descriptive analysis performed, results were compared existing guidelines...
We explored the current practice with respect to neuropsychological assessment of surgical epilepsy patients in European centers, aim harmonizing and establishing common standards. Twenty-six centers members "E-PILEPSY" (a pilot network reference refractory surgery), were asked report status adults children via two different surveys. There was a consensus among these regarding role neuropsychology presurgical workup. Strong agreement found on indications (localization, epileptic...
The European Union-funded E-PILEPSY network aims to improve awareness of, and accessibility to, epilepsy surgery across Europe. In this study we assessed current clinical practices in monitoring units (EMUs) the participating centers.A 60-item web-based survey was distributed 25 centers (27 EMUs) of 22 countries. questionnaire designed evaluate characteristics EMUs, including organizational aspects, admission, observation patients, procedures performed, safety issues, cost,...
To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015.We collected information on volumes types surgery, pathology, seizure outcome from 20 recognized reference centers 10 countries.We analyzed retrospective aggregate data 1859 operations. The proportion surgeries significantly increased over time (P < .0001). Engel class I was achieved 69.3% children, with no significant improvement 2015. histopathological findings consistent glial scars the ages...
Summary Objective To assess long‐term outcome and identify prognostic factors of radiofrequency thermocoagulation ( RFTC ) following stereoelectroencephalography SEEG explorations in particularly complex cases focal epilepsy. Methods We retrospectively reviewed the medical charts, video‐ recordings, outcomes for 23 patients (aged 6–53 years) treated with ‐guided , whom 15 had negative magnetic resonance imaging MRI findings, 10 were considered noneligible resective surgery after . Two to 11...
Background: The Notch signaling pathway is an important regulator of stem cell activity in various tissues, including the central nervous system. It has been implicated neurodevelopmental processes, neuronal differentiation and synaptic plasticity. Research suggests that its expression may be associated with certain epileptogenic lesions, particularly those origin. aim this study was to investigate Notch-1 brain biopsies from cases pharmacoresistant epilepsy. Methods: Here, we used...
To gain new insights into the clinical presentation, causes, treatment and prognosis of epilepsia partialis continua (EPC), to develop hypotheses be tested in a prospective investigation.In this retrospective multicenter study, all cases were included that fulfilled these criteria: constantly repeated fragments epileptic seizures, with preserved consciousness, lasting ≥ 1 h representing locally restricted motor or sensory activity. Single episodes when they lasted for minimum day. EPC...
Anaplastic ganglioglioma is a rare tumour, and diagnosis has been based on histological criteria. The 5th edition of the World Health Organization Classification Tumours Central Nervous System (CNS WHO) does not list anaplastic as distinct due to lack molecular data in previous publications. We retrospectively compiled cohort 54 histologically diagnosed gangliogliomas explore whether profiles these tumours represent separate type or resolve into other entities.Samples were subjected review,...
Abstract BACKGROUND Stereoelectroencephalography (SEEG) requires high-quality angiographic studies because avascular trajectory planning is a prerequisite for the safety of this procedure. Some epilepsy surgery groups have begun to use computed tomography angiography and magnetic resonance T1-weighted sequence with contrast enhancement purpose. OBJECTIVE To present first series patients SEEG based on (MRA). METHODS Thirty-six explorations drug-resistant focal were performed from January 2013...
West syndrome is an age‐dependent epileptic encephalopathy. Despite potential side effects, hormonal therapy remains the main treatment for syndrome. Here, we report on 10 patients receiving steroid who presented with unusual, mostly hyperkinetic, movements. Facial grimacing, repetitive mouth opening, adduction and abduction of upper lower extremities, periodical strabismus in different combinations were observed all patients, independent formulation, dose, duration, efficacy treatment....
The purpose of the study was to evaluate incidence a possible combination rolandic and absence signs in epileptic children, which remains subject controversy. medical files electroencephalographic (EEG) records children with rolandic, childhood absence, juvenile epilepsy were retrospectively analyzed. During antiepilepsy treatment, 6 66 patients epilepsy, most them initial carbamazepine therapy, had absences generalized spike-wave discharges secondarily type. Five cases 34 3 11 identified an...
OBJECTIVE Stereoelectroencephalography (SEEG)–guided radiofrequency thermocoagulation (RFTC) has the advantage of producing a lesion in epileptogenic zone (EZ) at end SEEG. The majority published SEEG-guided RFTCs have been bipolar and usually performed between contiguous contacts same electrode. In present study, authors evaluate safety, efficacy, benefits monopolar RFTC METHODS This study included series 31 consecutive patients who had undergone SEEG for drug-resistant focal epilepsy...