A5019054651- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Epilepsy research and treatment
- Reproductive Physiology in Livestock
- Uterine Myomas and Treatments
- Glioma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Fetal and Pediatric Neurological Disorders
- COVID-19 Impact on Reproduction
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neuropharmacology Research
- Long-Term Effects of COVID-19
- Cancer Risks and Factors
- Pregnancy and Medication Impact
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Cardiac tumors and thrombi
- Multiple and Secondary Primary Cancers
- Gynecological conditions and treatments
- Systemic Sclerosis and Related Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Engineering Technology and Methodologies
- Urticaria and Related Conditions
- Tuberous Sclerosis Complex Research
University Hospital St. Ivan Rilski
2021-2025
Women’s Health Care
2024
Medical University of Sofia
2024
Alexandrovska Hospital
2021
Background: The Notch signaling pathway is an important regulator of stem cell activity in various tissues, including the central nervous system. It has been implicated neurodevelopmental processes, neuronal differentiation and synaptic plasticity. Research suggests that its expression may be associated with certain epileptogenic lesions, particularly those origin. aim this study was to investigate Notch-1 brain biopsies from cases pharmacoresistant epilepsy. Methods: Here, we used...
Adenomyosis and endometriosis are distinct gynecological disorders characterized by ectopic growth of endometrial tissue. Their etiology remains unclear, but stem cells have been implicated in both. The aim this study was to investigate compare the quantity NOTCH1+ CD117+ adenomyosis lesions. Immunohistochemical staining endometrium biopsies using antibodies against NOTCH1 CD117 performed. spatial distribution stromal positive for these markers were determined compared between Additionally,...
Introduction/Background: Colposcopy-directed targeted biopsy has been established as a proven technique for identifying cervical precancerous lesions. The qualifications of the colposcopist significantly impact subjective evaluation affected areaduring colposcopy. Large Loop Excision Transformation Zone (LLETZ) procedure is most commonly used excisional method treating present study aimed to investigate correlation between colposcopic (colposcopic impression) and histological diagnosis...
Vulvar cancer (VC) is a rare disease, of which the squamous vulvar carcinomas (SVCs) are most common histological subtype. SVC often associated with human papillomavirus (HPV) infection. HPV- positive SVCs multifocal, typically have non-keratinizing morphology, presence koilocytes and tend to arise in younger women (<50 years), smokers. The "hit run" theory has been subject longstanding curiosity tumor virology. scenario suggests that viruses an activating role development viral genome may...
The aim of this prospective study was to compare the endometrial microbiome between pregnant and non-pregnant women after frozen embryo transfer (FET) with euploid embryos. Endometrial biopsies were collected from 30 during mid-luteal phase in a natural cycle. FET performed embryos up 3 months biopsy. microbiota composition analysed using 16S rRNA (v4-v5 region) next generation sequencing (NGS). analysis different clinical outcomes biopsy (no pregnancy (n = 14), ultrasound confirmed 16))...
Melanoma is an aggressive cancer with a high potential for metastasis, commonly spreading to organs such as the lungs, brain, liver, and bones. Bone metastases, particularly spine, are frequent complication can result in severe pain, spinal cord compression, neurological deficits. Prompt diagnosis treatment critical, though managing metastases from melanoma poses significant challenges. We present case of 41-year-old man history malignant who developed acute paraplegia following pathological...
Herein, we report the first case of mild malformation cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) in Bulgaria. It is a newly recognised clinico-pathological entity medically intractable focal paediatric patients. The patient interest 9-year-old boy who has been suffering from refractory since age three. Positron emission tomography revealed consistent hypometabolism maximum orbitofrontal fronto-opercular cortex, as well adjacent anterior insula temporal...
Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE) is a recently described, histopathologically molecularly defined ( SLC35A2 ‐mutated) type malformation. Although increasingly recognized, the diagnosis MOGHE remains challenge. We present characteristics first six patients diagnosed in Bulgaria, aim to facilitate identification, proper presurgical evaluation, surgical treatment approach this disease. Methods Revision...
Abstract As the main treatment modality of central neural system germinomas is radiotherapy and/or chemotherapy, exact initial diagnosis disease crucial. Depending on different national protocols, histologic verification can be obligatory in some instances. This a serious challenge, taking into account usual location and nonspecific macroscopic appearance these lesions. Here, we propose safe effective method intraoperative tumor enhancement that increase confidence surgeon during intervention.
Aim: To investigate the influence of following prognostic factors: age, parity, hormonal status (premenopausal, postmenopausal), histological result from targeted biopsy (LSIL, HSIL), adequacy colposcopic examination (satisfactory, unsatisfactory colposcopy), type TZ (type 1, 2, 3), cervical lesions impression (diagnosis) lesion HSIL/Ca colli uteri in situ), size (up to 1/3; up 2/3; more than 2/3 circumference) for occurrence LSIL and situ final after LLETZ procedure.
To investigate the quantity of 2 stem cell types in endometrial stroma women undergoing vitro fertilization and their association with steroid hormone signaling implantation success after embryo transfer.Prospective cohort study.Private hospital.A total 109 patients fertilization.Not applicable.Immunohistochemistry staining biopsies taken during midluteal phase using antibodies against NOTCH1 CD117 was performed. The percentage stromal cells positive for these markers determined. link...
Abstract Аs many other viral pandemics, the current SARS-CoV-2 is also characterized by nervous system involvement, mainly in elderly patients with comorbidities. Recent scientific reports indicate that involvement of manifested a variety clinical symptoms related to severity and extent brain damage. Encephalopathy, encephalitis polyneuritis are among complications reported SARSCoV- 2. These have been morphologically proven. As an immune-privileged structure, neural tissue particularly...
It is an acknowledged fact that SARS-CoV-2 exhibits tropism for the human placenta. A possible mechanism of entry into host cells via angiotensin-converting enzyme 2 (ACE2) receptors, which are expressed in trophoblasts, endothelial cells, and macrophages. The present study describes a case spontaneous miscarriage 20th gestational week after maternal infection. placenta various fetal organs were examined structural alterations expression viral nucleocapsid protein several immune cell markers...