A5084055783- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Neurological disorders and treatments
- Epilepsy research and treatment
- Porphyrin and Phthalocyanine Chemistry
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Parkinson's Disease and Spinal Disorders
- Neurofibromatosis and Schwannoma Cases
- Transcranial Magnetic Stimulation Studies
- Trigeminal Neuralgia and Treatments
- EEG and Brain-Computer Interfaces
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Cerebral Venous Sinus Thrombosis
- Cancer, Hypoxia, and Metabolism
University Hospital St. Ivan Rilski
2021-2024
Medical University of Sofia
2023
Sofia University "St. Kliment Ohridski"
2022
<b><i>Introduction:</i></b> The aim of this study was to present a novel technique for subthalamic nucleus (STN) deep brain stimulation (DBS) implantation under general anesthesia by using intraoperative motor-evoked potentials (MEPs) through direct lead and determining their correlation the thresholds postoperative stimulation-induced side effects. <b><i>Methods:</i></b> This included 22 consecutive patients with advanced Parkinson’s disease...
OBJECTIVE Stereoelectroencephalography (SEEG)–guided radiofrequency thermocoagulation (RFTC) has the advantage of producing a lesion in epileptogenic zone (EZ) at end SEEG. The majority published SEEG-guided RFTCs have been bipolar and usually performed between contiguous contacts same electrode. In present study, authors evaluate safety, efficacy, benefits monopolar RFTC METHODS This study included series 31 consecutive patients who had undergone SEEG for drug-resistant focal epilepsy...
Parkinson's disease (PD) significantly impedes, especially at its advanced stages, the health-related quality of life (QoL) patients. The questionnaire (PDQ-39) is a widely-used measure assessing impact on patients' QoL. To date, reliability PDQ-39 has not been selectively evaluated for patients particular delineated stage PD progression. Against this backdrop, study aimed firstly to evaluate comprehensively internal consistency and constituent scales specifically stages who were candidates...
Abstract As the main treatment modality of central neural system germinomas is radiotherapy and/or chemotherapy, exact initial diagnosis disease crucial. Depending on different national protocols, histologic verification can be obligatory in some instances. This a serious challenge, taking into account usual location and nonspecific macroscopic appearance these lesions. Here, we propose safe effective method intraoperative tumor enhancement that increase confidence surgeon during intervention.
Abstract Porphyrins used as photosensitizers are accumulated selectively in glioblastoma cells due to the latter heme metabolism disorders and could be effectively for intraoperative fluorescence staining of tumor formation differentiation from normal brain parenchyma. The aim this work was investigate photodynamic properties 5-ALA/PpIX on stem cell cultures isolated glioblastoma. Supernatant samples photosensitizer-treated lines were evaluation photosensitizers’ accumulation investigated...
Abstract Glioblastoma (GBM) is the most common and severe type of brain tumor. Surgery subsequent radiotherapy chemotherapy do not lead to sufficient results in treatment this malignancy, mostly due its specific morphology. Only about 6% patients advanced age survive 5 years after being diagnosed with GBM. Therefore, scientists are working on alternative therapies that would more effective long-term glioblastoma. Photodynamic therapy (PDT) photodiagnostics (PD) such unconventional methods...
Investigations into efficacy and mechanisms of impact in photodynamic treatment (PDT) with different photosensitizers, based on porphyrins phthalocyanines, stem cells cultures isolated from human glioblastoma were carried out.
Stereotactic electroencephalography (SEEG) is an important method for invasive presurgical exploration of candidates epilepsy surgery by means stereotactic implantation intracerebral electrodes without craniotomy. Implantations through craniotomy in drug-resistant epileptic patients have been performed Bulgaria the 1980s, but no further development followed. The aim our study to present first Bulgarian series with explored SEEG. Our included 53 Leksell frame, software avascular trajectory...