A5000703034- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Regional Development and Policy
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- CNS Lymphoma Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Spine and Intervertebral Disc Pathology
- Inflammatory Myopathies and Dermatomyositis
- Autophagy in Disease and Therapy
- Neurosurgical Procedures and Complications
- Lymphoma Diagnosis and Treatment
- Hungarian Social, Economic and Educational Studies
- Neuroblastoma Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Myeloid Leukemia Research
- Cervical and Thoracic Myelopathy
- Cancer Cells and Metastasis
- Moyamoya disease diagnosis and treatment
- Avian ecology and behavior
- Cruise Tourism Development and Management
- Takotsubo Cardiomyopathy and Associated Phenomena
- Spinal Hematomas and Complications
- Mathematical Biology Tumor Growth
University Hospital St. Ivan Rilski
2014-2024
Medical University of Sofia
2020-2024
Centre Hospitalier Régional et Universitaire de Nancy
2024
Université de Lorraine
2014-2024
Trakia University
2017-2024
Hôpital Nord
2024
California Environmental Protection Agency
2023
Inserm
2001-2022
Sofia University "St. Kliment Ohridski"
2022
Délégation Centre-Est
2019
Abstract Because stem cells are often found to improve repair tissue including heart without evidence of engraftment or differentiation, mechanisms underlying wound healing still elusive. Several studies have reported that can fuse with cardiomyocytes either by permanent partial cell fusion processes. However, the respective physiological impact these two processes remains unknown in part because lack knowledge resulting hybrid cells. To further characterize fusion, we cocultured mouse fully...
Overexpression of the protein c-mip in mice produces phenotypes similar to various idiopathic kidney disorders.
<h3>BACKGROUND:</h3> A biofilm is found on the inner side of endotracheal tubes (ETT) in mechanically ventilated patients, but its features and role pneumonia remain unclear. <h3>METHODS:</h3> This prospective, observational, monocentric study included critically ill subjects. Measurement ETT volume was first performed before extubation using acoustic reflection method. After extubation, studied by means optical atomic force microscopy. Bacteriological analysis then compared with clinical...
The aim of this study was to correlate histological features and molecular characteristics in anaplastic oligodendrogliomas (AOs). 203 AO patients, enrolled the French national network POLA, were analyzed. genomic profiles 191 cases studied using arrays. IDH mutational status assessed by immunohistochemistry direct sequencing. 1p/19q codeletion present 79% associated with alpha-internexin expression (P < 10−4), IDH1/2 mutation chromosome 4 loss 10−3), better overall survival 10−4). Based on...
We present a study of in vitro cell migration two dimensions as first step towards understanding the mechanisms governing motility glioma cells. Our is based on cellular automaton model which aims at reproducing kinetics lump cells deposited substrate collagen. The dynamical effects attraction and motion inertia are introduced through adequate rules. compare density profiles given by to those obtained experimentally. result best fit indicates substantial cell-cell due communication gap...
The pathophysiology of dermatomyositis (DM) remains unclear, combining immunopathological mechanisms with ischaemic changes regarded as a consequence membranolytic attack complex (MAC)-induced capillary destruction. study is reappraisal the microvascular involvement in light organisation normal human muscle.Muscle microvasculature was analysed using 3D reconstructions serial sections immunostained for CD31, and histoenzymatic detection endogenous alkaline phosphatase activity microvessels....
BACKGROUND Recently, isocitrate dehydrogenase 1 ( IDH1 ) was identified as a major participant in glioma pathogenesis. At present, the enzymatic activity of protein has been main topic investigating its physiological function, but signaling pathway allocation unsuccessful. Interestingly, proteins regulated by phosphoinositide 3‐kinase (PI3K)/Akt signaling, are among top downregulated genes gliomas associated with high percentage and IDH2 mutations. The aim this study to investigate...
To study the expression and activity of matrix metalloproteinases (MMPs) MMP-2 (72-kd type IV collagenase, gelatinase A), MMP-3 (58-kd stromelysin-1), MMP-9 (92-kd B) tissue inhibitors MPs (TIMP) in patients with Guillain-Barre syndrome (GBS).MMPs are able to proteolysis basement membranes other components, promoting transmigration inflammatory cells from circulation nerve tissue.Twenty-five GBS were analyzed according phase disease, i.e., progression, plateau, early recovery, late recovery....
Background The difficulties in obtaining complete and stable endovascular occlusion are most evident for ruptured aneurysms exhibiting a wide neck unfavorable geometric features. aim of our study was to present experience with the Comaneci temporary bridging device aneurysms. Methods From May July 2017, 29 underwent embolization device. Angiographic clinical results were retrospectively analyzed. Results intracranial from different locations included. Successful achieved all lesions;...
The most frequent autoimmune adult inflammatory myopathies are dermatomyositis, polymyositis, inclusion body myositis, and sarcoid myopathy. Interleukin‐1 (IL‐1) is a pleiotropic molecule, implicated in the process, but also tissue protection remodelling. We evaluated immunocytochemical expression of IL‐1α β frozen muscle biopsy specimens from patients with dermatomyositis (15 cases), polymyositis (five myositis cases) myopathy cases). Positive immunoreactivities, were observed both cells...
Object. The reliable assessment of the invasiveness gliomas in vitro has proved elusive, because most invasion assays inadequately model vivo its complexity. Recently, organotypical brain cultures were successfully used short-term studies on glioma cell lines. In this paper authors report that human biopsy specimens directly implanted into rodent slices by using intraslice implantation system (ISIS) can be quantified with precision. was first validated demonstration that, long-term studies,...
Precipitating hydrophobic injectable liquid is a newly introduced embolic agent for endovascular embolization with some technical advantages over other agents. We present our initial experience precipitating in the treatment of cerebral arteriovenous malformations.From October 2015 to January 2018, 27 patients harboring malformations underwent 25. Clinical features, angiographic results, procedural details, complications, and follow-up details were retrospectively analyzed.Twenty-seven...
Diffuse invasion of the brain, an intrinsic property gliomas, renders these tumours incurable, and is a principal determinant their spatial temporal growth. Knowledge invasive potential gliomas highly desired in order to understand behaviour vivo. Comprehensive ex vivo studies including different histological types grades are however lacking, mostly because reliable physiological assays have been difficult establish. Using organotypic rodent brain slice assay, we evaluated invasiveness 42...
Population estimates for the diverse raptor assemblage of Dadia National Park, Greece.Dadia which is situated in north-eastern Greece, close to border with Bulgaria and Turkey, characterised by one most arrays breeding raptorial species Europe. The first survey was undertaken 1970s, but until 1999 surveys were circumstantial nonsystematic. Considering some these are globally endangered included Annex 1 Birds Directive, that raptors general considered key indicators biodiversity ecosystem...
Internal carotid artery (ICA) injury is a rare but potentially life-threatening complication of skull base and neck surgery. Although usually manifested by massive intraoperative haemorrhage, impairment the ICA might go unnoticed result in formation pseudoaneurysm, causing delayed bleeding. Often additional complications are observed such as thrombosis, spasm, embolism or carotico-cavernous fistula formation. The risk aggressive endonasal surgical interventions ranges from 1% to 9%. Digital...