A5114375608- Mesenchymal stem cell research
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Cardiac Valve Diseases and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Alzheimer's disease research and treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal and related cancers
- Cardiovascular Issues in Pregnancy
- Tissue Engineering and Regenerative Medicine
- Oral microbiology and periodontitis research
- Lipoproteins and Cardiovascular Health
- Erythropoietin and Anemia Treatment
- Genetic Associations and Epidemiology
- Protein Kinase Regulation and GTPase Signaling
- Thyroid and Parathyroid Surgery
- Periodontal Regeneration and Treatments
- Protease and Inhibitor Mechanisms
- Cancer Immunotherapy and Biomarkers
- Glutathione Transferases and Polymorphisms
- Nitric Oxide and Endothelin Effects
- Telomeres, Telomerase, and Senescence
- Probiotics and Fermented Foods
- Endoplasmic Reticulum Stress and Disease
Spanish National Cancer Research Centre
2021-2024
Molecular Oncology (United States)
2023
Hospital General Universitario Gregorio Marañón
2023
Complejo Hospitalario Universitario de Toledo
2022
Hospital Universitario Austral
2021
University of California, Los Angeles
2015-2020
Hospital Virgen de la Salud
2012-2020
Central University Hospital of Asturias
2000-2018
Centro de Biología Molecular Severo Ochoa
2011
Universidad Autónoma de Madrid
2011
The healthy oral microbiome is symbiotic with the human host, importantly providing colonization resistance against potential pathogens. Dental caries and periodontitis are two of world’s most common costly chronic infectious diseases caused by a localized dysbiosis microbiome. Bacterially produced small molecules, often encoded BGCs, primary communication media bacterial communities play crucial, yet largely unknown, role in transition from health to dysbiosis. This study provides...
Dental caries, the most common chronic infectious disease worldwide, has a complex etiology involving interplay of microbial and host factors that are not completely understood. In this study, oral microbiome 38 cytokines chemokines were analyzed across 23 children with caries 24 healthy dentition. De novo assembly metagenomic sequencing obtained 527 metagenome-assembled genomes (MAGs), representing 150 bacterial species. Forty-two these species had no in public repositories, thereby novel...
KRASG12C inhibitors have revolutionized the clinical management of patients with KRASG12C-mutant lung adenocarcinoma. However, patient exposure to these leads rapid onset resistance. In this study, we used genetically engineered mice compare therapeutic efficacy and emergence tumor resistance between genetic ablation mutant Kras expression pharmacological inhibition oncogenic KRAS activity. Whereas induces massive regression prevents appearance resistant cells in vivo, treatment...
Mesenchymal stem cell (MSC)-mediated therapy has been shown to be clinically effective in regenerating tissue defects. For improved regenerative therapy, it is critical isolate homogenous populations of MSCs with high capacity differentiate into appropriate tissues. The utilization surface antigens provides a means identify from various However, few markers that consistently highly have validated, making challenging for routine clinical applications and all the more imperative reliable...
Objective: to examine the association between coronary artery disease and polymorphisms at angiotensin-converting enzyme (ACE) angiotensin II type 1 receptor (AT1R) genes. Methods: A total of 181 patients younger than 50 years 240 controls from same homogeneous Caucasian population (Asturias, Northern Spain) were genotyped (using polymerase chain reaction) for ACE insertion/deletion (ACE-I/D) AT1R A/C transversion (AT1R-A/C) (3′-untranslated region) polymorphisms. Results: The DD-genotype...
Mesenchymal stem cells (MSCs) are a promising tool in regenerative medicine due to their capacity differentiate into multiple lineages. In addition MSCs isolated from bone marrow (BMSCs), adult craniofacial tissues including dental pulp (DPs) using various cell surface markers. However, there has been lack of consensus on set makers that reproducibly effective at isolating putative multipotent mesenchymal (DMSCs). this study, we used different combinations markers (CD51/CD140α, CD271, and...
Embryonic stem cell-derived mesenchymal stromal cells (MSCs; also known as cells) represent a promising source for bone regenerative medicine. Despite remarkable advances in cell biology, the molecular mechanism regulating differentiation of human embryonic (hESCs) into MSCs remains poorly understood. Here, we report that inhibition IκB kinase (IKK)/nuclear factor kappa B (NF-κB) signaling enhances hESCs by expediting loss pluripotent markers and increasing expression MSC surface markers. In...
Several studies based on different populations worldwide have described an association between cardiovascular diseases and genetic variations in the apolipoprotein E (A:POE), angiotensinogen (A:GT), angiotensin receptor type 1 (A:T1R), angiotensin-converting enzyme (A:CE) genes. In addition, there is growing evidence of interaction hypercholesterolemia renin-angiotensin system risk for hypertension atherosclerosis.To determine whether DNA polymorphisms A:POE (epsilon2, epsilon3, epsilon4...
We conducted a multicentre, retrospective, observational study including patients with solid tumours (excluding breast cancer) that received granulocyte colony-stimulating factors (G-CSF) and chemotherapy. investigated the effectiveness of daily vs. non-daily G-CSFs (pegfilgrastim) adjusting by potential confounders. The included 391 (211 G-CSF; 180 pegfilgrastim), from whom 47.3% primary prophylaxis (PP) (57.8% 26.3% secondary (SP: initiation after cycle 1 no reactive treatment in any...
The use of immune checkpoint inhibitors has emerged as an effective treatment option for patients with several tumor types. By increasing the activity system, they can induce inflammatory side effects, which are often termed immune-related adverse events. These pathophysiologically unique toxicities, compared those from other anticancer therapies. In addition, spectrum target organs is very broad. Immune-inflammatory events be life threatening. Prompt diagnosis and pharmacological...
The LRP-associated protein is involved in the amount of mature LRP expressed on liver and brain. main ApoE receptor also binds alpha2-macroglobulin (alpha2M), a that associates with beta-amyloid (betaA). By binding to alpha2M, responsible for clearance secreted betaA, thus preventing fibril formation. Genetic variation at APOE, A2M, genes has been associated risk developing late-onset Alzheimer disease (LOAD). We genotyped 373 patients, 300 controls, 100 healthy elderly controls common...
In mammals, the KRAS locus encodes two protein isoforms, KRAS4A and KRAS4B, which differ only in their C terminus via alternative splicing of distinct fourth exons. Previous studies have shown that whereas expression is essential for mouse development, isoform expendable. Here, we generated a strain carries terminator codon exon 4B leads to an unstable KRAS4B154 truncated polypeptide, hence resulting bona fide Kras4B-null allele. contrast, this leaves unaffected. Mice selectively lacking...
Background: Only a small percentage of long-term alcoholics develop liver cirrhosis. Genetic and non-genetic factors have been implicated in the risk developing this disease. Among genetic factors, case?control studies suggest an association with some polymorphisms at alcohol dehydrogenase cytochrome P450IIE1 genes. N-Acetyltransferase-2 metabolizes multiple compounds, transforming them to organ-toxic compounds others into non-toxic molecules. Slow- rapid-acetylator individuals exist most...
Background The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as α2-macroglobulin (α2 M) and apolipoprotein E. LRP involved in the clearance of lipids from bloodstream expressed atherosclerotic plaque. LRP-associated (LRPAP humans, RAP mice) acts a chaperone protein, stabilizing nascent peptide endoplasmic reticulum Golgi complex. In mice, amount activity was modulated by RAP, RAP-null mice showed higher levels total cholesterol. Objective To...