A5000081674- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Misinformation and Its Impacts
- Urinary Bladder and Prostate Research
- Parathyroid Disorders and Treatments
- Renal and Vascular Pathologies
- Data-Driven Disease Surveillance
- Magnesium in Health and Disease
- Organ Transplantation Techniques and Outcomes
- Public Relations and Crisis Communication
- Renal Diseases and Glomerulopathies
- Pharmacological Effects and Toxicity Studies
- Complement system in diseases
- Zoonotic diseases and public health
- Urinary Tract Infections Management
- COVID-19 epidemiological studies
- Genetic Syndromes and Imprinting
- Schizophrenia research and treatment
- Biomedical Research and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Dialysis and Renal Disease Management
- Transplantation: Methods and Outcomes
- Helicobacter pylori-related gastroenterology studies
Althaia
2022-2025
Hospital Universitario La Paz
2014-2024
École Polytechnique Fédérale de Lausanne
2023-2024
Hospital La Paz Institute for Health Research
2023
European Centre for Disease Prevention and Control
2015-2022
Hospital Clínic de Barcelona
2022
University College Dublin
2018
Hospital Universitario Príncipe de Asturias
2012-2018
Universidad Nacional de Córdoba
2017
Instituto de Investigación Médica Mercedes y Martín Ferreyra
2017
El síndrome hemolítico urémico (SHU) es una entidad clínica definida por la tríada anemia hemolítica no inmune, trombocitopenia e insuficiencia renal aguda, en que las lesiones subyacentes están mediadas un proceso de microangiopatía trombótica (MAT) sistémico. Distintas causas pueden desencadenar el MAT caracteriza SHU. En este documento consideramos SHU atípico (SHUa) como subtipo los fenómenos son fundamentalmente consecuencia del daño producido endotelio microvasculatura y otros órganos...
Whole-genome sequencing (WGS) has become an essential tool for public health surveillance and molecular epidemiology of infectious diseases antimicrobial drug resistance. It provides precise geographical delineation spread enables incidence monitoring pathogens at genotype level. Coupled with epidemiological environmental investigations, it delivers ultimate resolution tracing sources epidemic infections. To ascertain the level implementation WGS-based typing national investigation...
An infodemic is an overflow of information varying quality that surges across digital and physical environments during acute public health event. It leads to confusion, risk-taking, behaviors can harm lead erosion trust in authorities responses. Owing the global scale high stakes emergency, responding related pandemic particularly urgent. Building on diverse research disciplines expanding discipline infodemiology, more evidence-based interventions are needed design management tools implement...
Primary hyperoxaluria (PH) as a cause of ESRD in children is believed to have poor outcomes. Data on management and outcomes these remain scarce.This study included patients aged <19 years who started renal replacement therapy (RRT) between 1979 2009 from 31 countries providing data large European registry.Of 9247 incident receiving RRT, 100 had PH. PH were significantly younger than non-PH at the start RRT. The median age RRT decreased 9.8 1979-1989 1.5 2000-2009. Survival was 86%, 79%, 76%...
In high or moderate risk populations, periodic surveillance of patients at progression from gastric precursor lesions (PL) to cancer (GC) is the most effective strategy for reducing burden GC. Incomplete type intestinal metaplasia (IIM) may be considered as best candidate, but it still controversial and more research needed. To further assess subtypes IM predictors GC occurrence.A follow-up study was carried-out including 649 patients, diagnosed with PL between 1995-2004 in 9 participating...
Abstract Infectious disease threat events (IDTEs) are increasing in frequency worldwide. We analyzed underlying drivers of 116 IDTEs detected Europe during 2008–2013 by epidemic intelligence at the European Centre Disease Prevention and Control. Seventeen were identified categorized into 3 groups: globalization environment, sociodemographic, public health systems. A combination >2 was responsible for most IDTEs. The driver category environment contributed to 61% individual IDTEs, top 5 all...
Haemolytic uraemic syndrome (HUS) is a clinical entity defined as the triad of nonimmune haemolytic anaemia, thrombocytopenia, and acute renal failure, in which underlying lesions are mediated by systemic thrombotic microangiopathy (TMA). Different causes can induce TMA process that characterises HUS. In this document we consider atypical HUS (aHUS) sub-type phenomena consequence endotelial damage microvasculature kidneys other organs due to disregulation activity complement system. recent...
West Nile virus (WNV) is transmitted by mosquitoes in both urban as well rural environments and can be pathogenic birds, horses humans. Extrinsic factors such temperature land use are determinants of WNV outbreaks Europe, along with intrinsic the vector virus. With a multivariate model for transmission we computed probability infection 2014, July 2014 anomalies. We applied anomalies under balanced A1B climate change scenario (mix all energy sources, fossil non-fossil) 2025 2050 to project...
Infectious disease threat events (IDTEs) are increasing in frequency worldwide. We analyzed underlying drivers of 116 IDTEs detected Europe during 2008-2013 by epidemic intelligence at the European Centre Disease Prevention and Control. Seventeen were identified categorized into 3 groups: globalization environment, sociodemographic, public health systems. A combination >2 was responsible for most IDTEs. The driver category environment contributed to 61% individual IDTEs, top 5 all travel...
Background The European Centre for Disease Prevention and Control (ECDC) systematically collates information from sources to rapidly detect early public health threats. lack of a freely available, customisable automated warning tool using data Twitter prompted the ECDC develop epitweetr, which collects, geolocates aggregates tweets generating signals email alerts. Aim This study aims compare performance epitweetr manually monitoring purpose detecting Methods We calculated general specific...
Abstract Online public health discourse is becoming more and important in shaping dynamics. Large Language Models (LLMs) offer a scalable solution for analysing the vast amounts of unstructured text found on online platforms. Here, we explore effectiveness (LLMs), including GPT models open-source alternatives, extracting stances towards vaccination from social media posts. Using an expert-annotated dataset posts related to vaccination, applied various LLMs rule-based sentiment analysis tool...
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is an autosomal recessive tubular disorder characterized by excessive renal magnesium calcium excretion chronic kidney failure. This rare disease caused mutations in the CLDN16 CLDN19 genes. These genes encode tight junction proteins claudin-16 claudin-19, respectively, which regulate paracellular ion reabsortion kidney. Patients gene also present severe visual impairment. Our goals this study were to examine clinical...
Health-related quality of life (HRQoL) patients with X-linked hypophosphatemia (XLH) is lower than that both the general population and other chronic diseases, mainly due to diagnostic delay, treatment difficulties, poor psychosocial support, problems social integration. Early diagnosis optimal are paramount control disease in XLH, avoid complications, maintain or improve their HRQoL. We, therefore, analyzed HRQoL pediatric adult XLH treated conventional therapy Spain.We used several...
To determine which variables besides bladder dysfunction can help to predict the outcome of renal function in boys with posterior urethral valves (PUV).All 40 patients PUV this retrospective study were diagnosed and began treatment our hospital within first 3 months life, have had >or= 5 years follow-up. At time diagnosis, 33 insufficiency (RI) seven normal (RF). 16 chronic failure (CRF) 24 RF. We compared their RF (initial during follow-up), vesico-ureteric reflux (VUR), urinary tract...
Background: Vaccination against infectious diseases prevents diseases, saves lives, and reduces healthcare costs. However, trust, accessibility, public perceptions influence vaccine acceptance or refusal. Risk communication community engagement (RCCE) is key in addressing inaccurate claims misconceptions, improving coverage. This study examines how stance towards vaccination evolved Brazil from 2013 to 2019 using Twitter data. Methods: We collected tweets Portuguese containing...
Abstract Folate and vitamin B 12 are associated with neurodevelopment neurotransmitter synthesis insufficiencies of these nutrients could be linked to psychiatric disorders in children adolescents. To assess serum levels folate child adolescent inpatients examine possible links between different disorders. Child admitted a general hospital during 3-year period were included for analysis. measured when the subjects admitted. Psychiatric diagnoses made following DSM-5 criteria grouped into...
Large language models (LLMs) have demonstrated remarkable capabilities in various natural processing tasks, including text classification, information extraction, and sentiment analysis. Despite their increased usage development, there are no standardized benchmarking frameworks for domain-specific applications. The objective of this study is to develop test an open-source solution that enables intuitive, easy rapid commercial LLMs public health use cases. An LLM prediction prototype was...
To investigate the extent to which different types of bladder dysfunction can affect long-term renal function in boys with posterior urethral valves (PUV).Renal and were retrospectively assessed 59 PUV (mean age 10 years, range 5-17). All patients included study had at least 4 years follow-up their behaviour been evaluated two urodynamic studies. At time study, boys, 37 normal 22 end-stage disease (ESRD).Of by studies, 25 normally behaving bladders (42%) 34 some type (58%). Of ESRD, 15...
Abstract Background X-linked hypophosphatemia (XLH) is a hereditary rare disease caused by loss-of-function mutations in PHEX gene leading tohypophosphatemia and high renal loss of phosphate. Rickets growth retardation are the major manifestations XLH children, but there broad phenotypic variability. Few publications have reported large series patients. Current data on clinical spectrum disease, correlation with underlying mutations, long-term outcome patients conventional treatment needed,...