A5022120521- Dialysis and Renal Disease Management
- Central Venous Catheters and Hemodialysis
- Muscle and Compartmental Disorders
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Parathyroid Disorders and Treatments
- Renal function and acid-base balance
- Potassium and Related Disorders
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Heart Failure Treatment and Management
- Erythropoietin and Anemia Treatment
- Magnesium in Health and Disease
- Neurological and metabolic disorders
- Cardiac Arrhythmias and Treatments
- Vaccine Coverage and Hesitancy
- Metabolism and Genetic Disorders
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Kidney Injury Research
- Electrolyte and hormonal disorders
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Metabolomics and Mass Spectrometry Studies
Hospital Clínic de Barcelona
2019-2025
Universitat de Barcelona
2021-2024
Hospital Universitario de Gran Canaria Doctor Negrín
2022
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021
Universitat de València
2021
Consorci Sanitari Garraf
2021
Spanish Clinical Research Network
2019
Instituto de Salud Carlos III
2019
A novel class of membranes, medium cut-off (MCO) has recently been designed to achieve interesting removal capacities for middle and large molecules in hemodialysis (HD) treatments. The few studies published date have reported contradictory results regarding middle-sized when comparing MCO dialyzers versus used online hemodiafiltration (OL-HDF).A prospective, single-center study was carried out 22 patients. Each patient underwent 9 dialysis sessions with routine parameters, one an dialyzer...
Recently, several pharmaceutical companies have developed new medium cut-off (MCO) dialyzers for expanded hemodialysis (HDx). This study aimed to compare the safety and efficacy of four MCO dialyzers, against each other versus high-flux (HD) post-dilution hemodiafiltration (HDF).A prospective was carried out on 23 patients who underwent six dialysis sessions: two sessions with FX80 Cordiax in HD HDF, HDx Phylther 17-SD, Vie-18X, Elisio HX19 Theranova 400 dialyzers. The reduction ratios (RRs)...
Health-related quality of life (HRQoL) patients with X-linked hypophosphatemia (XLH) is lower than that both the general population and other chronic diseases, mainly due to diagnostic delay, treatment difficulties, poor psychosocial support, problems social integration. Early diagnosis optimal are paramount control disease in XLH, avoid complications, maintain or improve their HRQoL. We, therefore, analyzed HRQoL pediatric adult XLH treated conventional therapy Spain.We used several...
Introduction. Chronic heart failure (HF) has high rates of mortality and hospitalization in patients with advanced chronic kidney disease (aCKD). However, randomized clinical trials have systematically excluded aCKD population. We investigated current HF therapy receiving care specialized units. Methods. The Heart And Kidney Audit (HAKA) was a cross-sectional retrospective real-world study including outpatients from 29 Spanish centers. objective to evaluate how the treatment complied...
Background: High-volume online hemodiafiltration (OL-HDF) has proven to be the most efficient dialysis modality and offer better clinical outcomes in patients on hemodialysis. Longer more frequent sessions have demonstrated survival benefits. Methods: A single-center observational study of first one hundred nocturnal every-other-day OL-HDF was conducted with aim reporting experience this treatment schedule evaluating analytical as well patient technique survival. Results: Nocturnal alternate...
The dialysis membrane based on a hydrophilic polymer (Hydrolink NV) was designed to enhance the movement of adsorbed water at blood–membrane interface, aiming achieve antithrombogenic and antifouling effects. This study aimed assess performance albumin loss Hydrolink NV dialyzer in hemodialysis (HD) post-dilution hemodiafiltration (HDF) with different infusion flows (Qis) compare it FX CorAL HDF. A prospective carried out 20 patients. Patients underwent five sessions same routine parameters:...
The introduction of donor-derived free DNA (ddcfDNA) has emerged as an accurate non-invasive biomarker to diagnose rejection, compared classical ones. Here we evaluate our experience after its implementation in center in-house technique. Single-center cross-sectional study with extraction cell-free blood and quantification the ddcfDNA using AlloSeqcfDNA assay (CareDx) at time performing biopsies 'per protocol' or indication' between December 2020 2023. 172 graft were included (59 for...
Background Chronic kidney disease (CKD) is a significant cardiovascular (CV) risk factor, with dialysis-dependent CKD (DD-CKD) patients facing high mortality rates. Hypercholesterolemia another crucial CV typically managed lipid-lowering therapy, though its efficacy in DD-CKD remains uncertain. Evidence shows mixed results regarding the benefits of statins these patients. Citrate-based dialysates are known to reduce inflammatory biomarkers compared acetate-based ones, potentially impacting...
Most high-flux dialyzers can be used in both hemodialysis (HD) and online hemodiafiltration (OL-HDF). However, some of these have higher permeability should not prescribed for OL-HDF to avoid high albumin losses. The aim this study was compare the safety efficacy a currently dialyzer HD with those several other which only HD. A prospective, single-center carried out 21 patients. Each patient underwent 5 dialysis sessions routine parameters: 2 Helixone (HD postdilution OL-HDF) 1 session each...
This review provides a detailed analysis of hemodiafiltration (HDF), its progress from an emerging technique to potential conventional treatment for chronic hemodialysis patients, and current status. The article covers the advances, methods, clinical benefits HDF, specifically focusing on impact cardiovascular health, survival rates, overall well-being. also addresses questions about safety HDF evidence dispel concerns related elimination beneficial substances infection risks. Additionally,...
The COVID-19 pandemic continues to be a worldwide health issue. Among hemodialysis (HD) patients, two-dose immunization schemes with mRNA vaccines have contributed preventing severe cases; however, some not produced sufficient humoral response, and most developed rapid decline in antibody levels over the months following vaccination. This observational, prospective, multi-center study evaluated response terms of presence IgG antibodies receptor-binding domain S1 spike antigen SARS-CoV-2...
Abstract Patients on peritoneal dialysis (PD) have an increased risk of cardiovascular disease (CVD) and atherogenic lipid profile generated by exposure to high glucose solutions. In the general population, reduction classic lipids biomarkers is associated with improved clinical outcomes; however, same results not been seen in PD a lack data this study aims fulfill. Single-center prospective observational cohort CKD patients who started renal replacement therapy continuous ambulatory...
Anemia is highly prevalent in end-stage chronic kidney disease patients, increasing their risk of receiving blood transfusions during and on the days after a transplant (KTx) surgery. However, there currently lack data that thoroughly describes this phenomenon population, associated factors, how they could benefit from application Patient Blood Management (PBM) guidelines.
X-linked hypophosphatemia (XLH) is a rare genetic disorder that increases fibroblast growth factor 23 (FGF23). XLH patients have an elevated risk of early-onset hypertension. The precise factors contributing to hypertension in yet be identified. A multicenter cross-sectional study adult diagnosed with XLH. Metabolomic analysis was performed using ultra-performance liquid chromatography (UPLC) coupled high-resolution mass spectrometer. Twenty subjects were included, which nine (45%) had...
La reciente conceptualización del síndrome cardiovascular-reno-metabólico (CRM) por la American Heart Association (AHA) abre una oportunidad al abordaje multidisciplinar y desde etapas tempranas de vida en estratificación riesgo, prevención el tratamiento precoz círculo vicioso generado interacción factores riesgo cardiovasculares, renales metabólicos agravado desarrollo enfermedades cardiovasculares (incluyendo todo su espectro: insuficiencia cardíaca, fibrilación auricular, enfermedad...
The choice of dialysate buffer in hemodialysis is crucial, with acetate being widely used despite complications. Citrate has emerged as an alternative due to its favorable effects, yet concerns persist about impact on calcium and magnesium levels. This study investigates the influence citrate (CD) without additional supplementation CKD-MBD biomarkers assesses their ability chelate divalent metals compared dialysates (AD). A prospective crossover was conducted a single center, involving...
Abstract Blood flow (Qb) is one of the dialysis parameters most strongly influencing performance modalities. However, few studies have compared different modalities in patients with low Qb. We conducted a prospective, single‐center study 21 patients. Each patient underwent four sessions routine parameters: high‐flux hemodialysis (HD), predilution hemodiafiltration (pre‐HDF), expanded HD (HDx), and postdilution HDF (post‐HDF). The removal ratios (RR) urea, creatinine, ß 2 ‐microglobulin,...
<b><i>Introduction:</i></b> COVID-19 is a highly contagious disease that has easily spread worldwide. Outpatient maintenance hemodialysis seems to entail an increased risk of contagion, and previous reports inform mortality among this population. <b><i>Methods:</i></b> We retrospectively analyzed clinical laboratory parameters, outcomes, management once discharged CKD-5D patients infected with SARS-CoV-2 from our health area....
Metabolic acidosis is a common problem in haemodialysis patients, but overcorrection has been associated with higher mortality. There no clear definition of the optimal serum bicarbonate target or dialysate bicarbonate. This study analysed impact reducing from 35 to 32 mEq/L on plasma levels cohort patients treated online haemodiafiltration (OL-HDF).We performed prospective stable chronic OL-HDF programme for at least 12 months Hospital Clinic Barcelona. We pre- and post-dialysis total...
Medium cutoff (MCO) membranes have resulted in a novel dialyzer class designed to improve membrane permeability and been postulated as an alternative online hemodiafiltration since MCO may achieve similar solute clearances. These incorporated into clinical practice, the term expanded HD (HDx) has proposed differentiate from high-flux hemodialysis. Efficacy, safety, quality of life comparison HDF versus HDx reviewed this article.