A5083541778- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- CAR-T cell therapy research
- Dialysis and Renal Disease Management
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Magnesium in Health and Disease
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Bone health and treatments
- Healthcare cost, quality, practices
- Nursing care and research
- Pharmacological Effects and Toxicity Studies
- Salivary Gland Disorders and Functions
- Systemic Sclerosis and Related Diseases
- Otitis Media and Relapsing Polychondritis
- COVID-19 Impact on Reproduction
- Renal and related cancers
- Muscle and Compartmental Disorders
- Genetic Syndromes and Imprinting
- Interpreting and Communication in Healthcare
- Health, Education, and Physical Culture
- Gout, Hyperuricemia, Uric Acid
- Chronic Kidney Disease and Diabetes
- Chemotherapy-related skin toxicity
Fundació Clínic per a la Recerca Biomèdica
2023-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022-2025
Hospital Clínic de Barcelona
2022-2024
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2023-2024
Universitat de Barcelona
2024
Areté Associates (United States)
2023
Puigvert Foundation
2019-2022
Antenor Orrego Private University
2020-2021
Coronavirus disease 2019 (COVID-19) predisposes patients to bacterial and fungal superinfections due the impairment of immunological system. Among associated opportunistic infections, mucormycosis is one least frequent but with highest mortality. We describe two cases in kidney transplant recipients, while they were hospitalized for SARS-CoV-2 pneumonia, rhinosinusal musculoskeletal involvement, respectively.
C3 glomerulopathy is a rare disease caused by fluid phase dysregulation of the alternative complement pathway. Currently, treatment depends on clinical and histological severity includes nephroprotection, unspecific immunosuppression terminal blockers (C5), without having an etiological approved. has high recurrence rates after kidney transplantation with risk graft loss. Fortunately, new molecules are being developed that specifically target proximal pathway, such as iptacopan, factor B...
Ischemia-reperfusion injury (IRI) upon transplantation is one of the most impactful events that kidney graft suffers during its life. Its clinical manifestation in recipient, delayed function (DGF), has serious prognostic consequences. However, different definitions DGF are subject to physicians' choices and centers' policies, a more objective tool quantify IRI needed. Here, we propose use donor-derived cell-free DNA (ddcfDNA) for this scope.
The introduction of donor-derived free DNA (ddcfDNA) has emerged as an accurate non-invasive biomarker to diagnose rejection, compared classical ones. Here we evaluate our experience after its implementation in center in-house technique. Single-center cross-sectional study with extraction cell-free blood and quantification the ddcfDNA using AlloSeqcfDNA assay (CareDx) at time performing biopsies 'per protocol' or indication' between December 2020 2023. 172 graft were included (59 for...
ABSTRACT Tubuloids have become a promising tool for kidney disease model and regeneration, although their ability integration regeneration in vivo is not well documented. Here we establish, characterize compare human tubuloids using two optimized protocols, which added prior isolation of tubular cells (Crude tubuloids) proximal (F4 tubuloids). Secondly, this protocol, healthy rat-derived were established. Finally, compared strategies to deliver GFP host: 1) subcapsular/intracortical...
The presence of donor‐specific antibodies (DSA), mainly against HLA, increases the risk allograft rejection. Moreover, antibody‐mediated rejection (ABMR) remains an important barrier to optimal long‐term outcomes after solid organ transplantation. development chimeric autoantibody receptor T lymphocytes has been postulated for targeted therapy autoimmune diseases. We aimed develop a DSA desensitization and ABMR, generating cells with HLA antibody (CHAR) that specifically eliminates...
Tacrolimus is pivotal in pancreas transplants but poses challenges maintaining optimal levels due to recipient differences. This study aimed explore the utility of time spent below therapeutic range and intrapatient variability predicting rejection
El hiperparatiroidismo secundario es uno de los componentes integrales las alteraciones del metabolismo óseo-mineral en la enfermedad renal crónica (ERC) o complejo chronic kidney disease-mineral bone disorder. Se ha demostrado que el desarrollo y progresión intervienen muchos factores, estrechamente interrelacionados, pero presencia e importancia hiporrespuesta (o resistencia) a acción hormona paratiroidea (PTH) poco comprendida. En esta revisión analizaremos sus antecedentes, factores...
ABSTRACT Background Renal transplant recipients with donor-specific anti-HLA antibodies are at an increased risk of antibody-mediated rejection (ABMR). Early protocolized renal biopsies may serve as a strategy to improve diagnosis in this patient population. Methods We evaluated 155 highly sensitized cPRA class I + II >90% pre-transplant from 2015 2022. Patients protocol within the first 2 weeks post-transplant were included. Results A total 122 patients included study. Of these, 13...
Herpes virus infections is not uncommon in solid organ transplantation patients. We report 3 cases with primary simplex type-1 (HSV1) infection acute liver failure (ALF). This a rare and potentially fatal entity that could be donor-derived infection. Although the initial clinical presentation non-specific, it should considered as differential diagnosis HSV-negative serology patients empirical treatment must started combination drastic reduction of immunosuppression. A strategy HSV...
Background The age of patients referred for kidney transplantation has increased progressively. However, the precise influence on transplant outcomes is controversial. Methods Etrospective study in which graft and recipient survival were assessed a cohort ≥75 years old recipients compared with contemporary younger one aged 60-65 through propensity score analysis. Results We included 106 between 57 median follow-up 31 [13-54] months. Unadjusted one- five-year did not significantly differ...
Se ha sugerido no usar «da ño» o «injuria» renal aguda por varias razones: 1) ausencia de tradición, 2) el término AKI es un cambio meramente cosmético pues se sigue definiendo la función y marcadores objetivos da ño, independientes función.Teóricamente sería posible que hubiera pacientes con deterioro agudo [IRA (AKI 1-3) FRA 3)] ño agudo, pero también sin IRA FRA. a Al describir los grados (categorías, estadios) ERC debería evitarse utilización del adjetivo «severa» utilizar «grave».Severa...
ABSTRACT This study reports a case of 13-year-old male with 3-year history severe and intermittent hypokalemia episodes unknown origin, requiring admission to the intensive care unit (ICU) for long QT syndrome (LQTS), finally diagnosed redistributive secondary abuse β-adrenergic agonists in context probable factitious disorder.
Aunque el fósforo es un elemento indispensable para la vida, en naturaleza no se encuentra estado nativo sino combinado forma de fosfatos inorgánicos (PO43−), con niveles plasmáticos estrechamente regulados que asocian a efectos deletéreos y mortalidad cuando estos encuentran fuera normalidad. El interés creciente sobre acúmulo PO43− fisiopatología humana originó papel le atribuyó patogenia del hiperparatiroidismo secundario enfermedad renal crónica. En este artículo revisamos los mecanismos...
Abstract Background and Aims BK virus allograft nephropathy (BKVN) can develop graft loss. The aim of this study was to describe viraemia BKVN related factors, our experience in treatment the impact survival. Method We introduce a retrospective cohort 78 kidney transplant recipients (KTRs) with BKV between January 2013 from 2020 follow-up until December 31, 2022 center. Results Thirty-four (43%) were living donor KTRs, 30 (38.5%) DBD, 11 (14.1%) DCD III, 2 (4.3%) II. Twenty-seven (34.6%)...