A5034270977- Dialysis and Renal Disease Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Renal Transplantation Outcomes and Treatments
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Renal function and acid-base balance
- Central Venous Catheters and Hemodialysis
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
- Lipoproteins and Cardiovascular Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Long-Term Effects of COVID-19
- Potassium and Related Disorders
- Genetic and Kidney Cyst Diseases
- Magnesium in Health and Disease
- Metabolism and Genetic Disorders
- Sodium Intake and Health
- Neurological and metabolic disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacological Effects and Toxicity Studies
- Transplantation: Methods and Outcomes
- Chronic Lymphocytic Leukemia Research
- Vaccine Coverage and Hesitancy
- Erythropoietin and Anemia Treatment
Hospital Clínic de Barcelona
2019-2025
Universitat de Barcelona
2020-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2024
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
2024
Departament de Salut
2021
Sistema Nacional de Salud
2021
Hôpital Armand-Trousseau
2020
Assistance Publique – Hôpitaux de Paris
2020
Sorbonne Université
2020
Baystate Medical Center
2020
COVID-19 is novel infectious disease with an evolving understanding of its epidemiology and clinical manifestations. Immunocompromised patients often present atypical presentations viral diseases. Herein we report a case infection in solid organ transplant recipient, which the first symptoms were gastrointestinal fever, further progressed to respiratory 48 hours. In these high risk populations, protocols for screening SARS-Cov2 may be needed re-evaluated.
C3 glomerulopathy is a rare disease caused by fluid phase dysregulation of the alternative complement pathway. Currently, treatment depends on clinical and histological severity includes nephroprotection, unspecific immunosuppression terminal blockers (C5), without having an etiological approved. has high recurrence rates after kidney transplantation with risk graft loss. Fortunately, new molecules are being developed that specifically target proximal pathway, such as iptacopan, factor B...
Recently, several pharmaceutical companies have developed new medium cut-off (MCO) dialyzers for expanded hemodialysis (HDx). This study aimed to compare the safety and efficacy of four MCO dialyzers, against each other versus high-flux (HD) post-dilution hemodiafiltration (HDF).A prospective was carried out on 23 patients who underwent six dialysis sessions: two sessions with FX80 Cordiax in HD HDF, HDx Phylther 17-SD, Vie-18X, Elisio HX19 Theranova 400 dialyzers. The reduction ratios (RRs)...
Ischemia-reperfusion injury (IRI) upon transplantation is one of the most impactful events that kidney graft suffers during its life. Its clinical manifestation in recipient, delayed function (DGF), has serious prognostic consequences. However, different definitions DGF are subject to physicians' choices and centers' policies, a more objective tool quantify IRI needed. Here, we propose use donor-derived cell-free DNA (ddcfDNA) for this scope.
The introduction of donor-derived free DNA (ddcfDNA) has emerged as an accurate non-invasive biomarker to diagnose rejection, compared classical ones. Here we evaluate our experience after its implementation in center in-house technique. Single-center cross-sectional study with extraction cell-free blood and quantification the ddcfDNA using AlloSeqcfDNA assay (CareDx) at time performing biopsies 'per protocol' or indication' between December 2020 2023. 172 graft were included (59 for...
Background Chronic kidney disease (CKD) is a significant cardiovascular (CV) risk factor, with dialysis-dependent CKD (DD-CKD) patients facing high mortality rates. Hypercholesterolemia another crucial CV typically managed lipid-lowering therapy, though its efficacy in DD-CKD remains uncertain. Evidence shows mixed results regarding the benefits of statins these patients. Citrate-based dialysates are known to reduce inflammatory biomarkers compared acetate-based ones, potentially impacting...
To address all the changes in management of people with diabetes (DM) and chronic kidney disease (CKD), under auspices Spanish Society Nephrology (SEN), Diabetic Nephropathy Study Group (GEENDIAB) decided to publish an updated Clinical Practice Guideline for detection diabetic (DKD). It is aimed at a wide audience clinicians treating CKD. The terminology patients has evolved toward more inclusive nomenclature that avoids underdiagnosis this entity. Thus, terms "diabetes disease" "diabetic...
This review provides a detailed analysis of hemodiafiltration (HDF), its progress from an emerging technique to potential conventional treatment for chronic hemodialysis patients, and current status. The article covers the advances, methods, clinical benefits HDF, specifically focusing on impact cardiovascular health, survival rates, overall well-being. also addresses questions about safety HDF evidence dispel concerns related elimination beneficial substances infection risks. Additionally,...
The COVID-19 pandemic continues to be a worldwide health issue. Among hemodialysis (HD) patients, two-dose immunization schemes with mRNA vaccines have contributed preventing severe cases; however, some not produced sufficient humoral response, and most developed rapid decline in antibody levels over the months following vaccination. This observational, prospective, multi-center study evaluated response terms of presence IgG antibodies receptor-binding domain S1 spike antigen SARS-CoV-2...
Abstract Blood flow (Qb) is one of the dialysis parameters most strongly influencing performance modalities. However, few studies have compared different modalities in patients with low Qb. We conducted a prospective, single‐center study 21 patients. Each patient underwent four sessions routine parameters: high‐flux hemodialysis (HD), predilution hemodiafiltration (pre‐HDF), expanded HD (HDx), and postdilution HDF (post‐HDF). The removal ratios (RR) urea, creatinine, ß 2 ‐microglobulin,...
Abstract Patients on peritoneal dialysis (PD) have an increased risk of cardiovascular disease (CVD) and atherogenic lipid profile generated by exposure to high glucose solutions. In the general population, reduction classic lipids biomarkers is associated with improved clinical outcomes; however, same results not been seen in PD a lack data this study aims fulfill. Single-center prospective observational cohort CKD patients who started renal replacement therapy continuous ambulatory...
<b><i>Introduction:</i></b> COVID-19 is a highly contagious disease that has easily spread worldwide. Outpatient maintenance hemodialysis seems to entail an increased risk of contagion, and previous reports inform mortality among this population. <b><i>Methods:</i></b> We retrospectively analyzed clinical laboratory parameters, outcomes, management once discharged CKD-5D patients infected with SARS-CoV-2 from our health area....
Metabolic acidosis is a common problem in haemodialysis patients, but overcorrection has been associated with higher mortality. There no clear definition of the optimal serum bicarbonate target or dialysate bicarbonate. This study analysed impact reducing from 35 to 32 mEq/L on plasma levels cohort patients treated online haemodiafiltration (OL-HDF).We performed prospective stable chronic OL-HDF programme for at least 12 months Hospital Clinic Barcelona. We pre- and post-dialysis total...
ABSTRACT Background A key feature of dialysis treatment is the prescription dialysate sodium (Na). This study aimed to describe practical implementation a new automated Na control biosensor and assess its tolerance beneficial clinical effects isonatraemic dialysis. Methods prospective was carried out in 86 patients who, along with their usual parameters, received following five consecutive phases for 3 weeks each: phase 0: baseline 5008 machine; 1 2: 6008 machine without activation same...
Anemia is highly prevalent in end-stage chronic kidney disease patients, increasing their risk of receiving blood transfusions during and on the days after a transplant (KTx) surgery. However, there currently lack data that thoroughly describes this phenomenon population, associated factors, how they could benefit from application Patient Blood Management (PBM) guidelines.
The choice of dialysate buffer in hemodialysis is crucial, with acetate being widely used despite complications. Citrate has emerged as an alternative due to its favorable effects, yet concerns persist about impact on calcium and magnesium levels. This study investigates the influence citrate (CD) without additional supplementation CKD-MBD biomarkers assesses their ability chelate divalent metals compared dialysates (AD). A prospective crossover was conducted a single center, involving...
Abstract Toray has created a new generation of dialyzers, the polysulphone (TS) UL series, and polymethylmethacrylate (PMMA) NF‐U which offer enhanced efficacy over previous TS‐S series NF‐H series. The aim this study was to evaluate safety these dialyzer versus contrasted expanded hemodialysis (HDx) postdilution hemodiafiltration (HDF). We conducted prospective in 12 patients. Each patient underwent six dialysis sessions: FX80 Cordiax HD, Toraysulfone TS‐1.8 Theranova 400 HDx, NF‐2.1 U HDF,...