A5057985351- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Central Venous Catheters and Hemodialysis
- Organ Transplantation Techniques and Outcomes
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Acute Kidney Injury Research
- Erythropoietin and Anemia Treatment
- Neurological Complications and Syndromes
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Diabetes Treatment and Management
- Parvovirus B19 Infection Studies
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Fungal Infections and Studies
- Extracellular vesicles in disease
- Organ and Tissue Transplantation Research
- Blood donation and transfusion practices
- Pharmaceutical industry and healthcare
Fundació Clínic per a la Recerca Biomèdica
2022-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2024
Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer
2024
Hospital Clínic de Barcelona
2018-2024
Universitat de Barcelona
2020-2021
Departament de Salut
2021
Sistema Nacional de Salud
2021
Abstract Blood flow (Qb) is one of the dialysis parameters most strongly influencing performance modalities. However, few studies have compared different modalities in patients with low Qb. We conducted a prospective, single‐center study 21 patients. Each patient underwent four sessions routine parameters: high‐flux hemodialysis (HD), predilution hemodiafiltration (pre‐HDF), expanded HD (HDx), and postdilution HDF (post‐HDF). The removal ratios (RR) urea, creatinine, ß 2 ‐microglobulin,...
<b><i>Introduction:</i></b> COVID-19 is a highly contagious disease that has easily spread worldwide. Outpatient maintenance hemodialysis seems to entail an increased risk of contagion, and previous reports inform mortality among this population. <b><i>Methods:</i></b> We retrospectively analyzed clinical laboratory parameters, outcomes, management once discharged CKD-5D patients infected with SARS-CoV-2 from our health area....
Metabolic acidosis is a common problem in haemodialysis patients, but overcorrection has been associated with higher mortality. There no clear definition of the optimal serum bicarbonate target or dialysate bicarbonate. This study analysed impact reducing from 35 to 32 mEq/L on plasma levels cohort patients treated online haemodiafiltration (OL-HDF).We performed prospective stable chronic OL-HDF programme for at least 12 months Hospital Clinic Barcelona. We pre- and post-dialysis total...
Abstract Toray has created a new generation of dialyzers, the polysulphone (TS) UL series, and polymethylmethacrylate (PMMA) NF‐U which offer enhanced efficacy over previous TS‐S series NF‐H series. The aim this study was to evaluate safety these dialyzer versus contrasted expanded hemodialysis (HDx) postdilution hemodiafiltration (HDF). We conducted prospective in 12 patients. Each patient underwent six dialysis sessions: FX80 Cordiax HD, Toraysulfone TS‐1.8 Theranova 400 HDx, NF‐2.1 U HDF,...
ABSTRACT Background Renal transplant recipients with donor-specific anti-HLA antibodies are at an increased risk of antibody-mediated rejection (ABMR). Early protocolized renal biopsies may serve as a strategy to improve diagnosis in this patient population. Methods We evaluated 155 highly sensitized cPRA class I + II &gt;90% pre-transplant from 2015 2022. Patients protocol within the first 2 weeks post-transplant were included. Results A total 122 patients included study. Of these, 13...
Recientemente, se ha incorporado a nuestras posibilidades terapéuticas una nueva clase de dializadores, las membranas medio cut-off (MCO), diseñadas para mejorar la permeabilidad y que podrían alcanzar eficacia similar hemodiafiltración. Para aumentar el conocimiento sobre su uso, objetivo del estudio fue valorar en MCO efecto superficie flujo sanguíneo (Qb) depurativa. Se incluyó 19 pacientes programa hemodiálisis. Cada paciente recibió 6 sesiones, varió membrana, 1,7 o 2,0 m2, Qb (300,...
Recently, a new class of dialyzers, medium cut-off membranes (MCO), designed to improve the permeability, which could provide an efficacy similar hemodiafiltration, have been incorporated into our therapeutic possibilities. To increase knowledge about its use, objective study was evaluate effect surface and blood flow (Qb) on depurative in MCO membranes. We included 19 patients hemodialysis. Each patient received 6 sessions, membrane varied, 1.7 or 2.0 m2, and/or Qb (300, 350, 400 450...
Herpes virus infections is not uncommon in solid organ transplantation patients. We report 3 cases with primary simplex type-1 (HSV1) infection acute liver failure (ALF). This a rare and potentially fatal entity that could be donor-derived infection. Although the initial clinical presentation non-specific, it should considered as differential diagnosis HSV-negative serology patients empirical treatment must started combination drastic reduction of immunosuppression. A strategy HSV...
Cardiovascular disease is the major cause of death in patients with type 1 diabetes. Of available risk predictors for this population, Steno Type Risk Engine (STENO T1) only one that includes kidney function as a factor, which well-described independent factor cardiovascular disease.We explore how simultaneous pancreas-kidney transplantation (SPKT) modifies predicted by STENO T1 through retrospective study including recipients first SPKT between 2000 and 2016.Two hundred sixty-eight mean age...
Abstract The Clearum dialyzer, built by Medtronic, became commercially available in several European countries 2020, but there are still no reports of vivo data. aim this study was to evaluate the efficacy and risk hypoalbuminemia dialyzer compared with previously evaluated hemodialysis (HD), expanded (HDx), postdilution hemodiafiltration (HDF) treatments. A prospective carried out 15 patients. Each patient underwent seven dialysis sessions: FX80 Cordiax HD, HS17 Phylther 17‐SD HDx,...
Primary membranous nephropathy (PMN) is an autoimmune disease limited to the kidney that characterized by presence of circulating PLAR2 antibodies in 70% cases and usually positivity for PLA2R IgG4 immunohistochemistry (IHC) staining. We report first documented case PMN (PLA2R positive) a deceased donor, transplanted two different recipients their clinical immunological evolution through serial biopsies. Recipient A's allograft biopsy (Day 26) was compatible with MN both positive...
Abstract Background and Aims Despite offering superior outcomes for patients with end-stage kidney disease, transplantation poses significant cardiovascular risks. Recently, histopathological findings in chronic disease have been associated all-cause mortality events, but there is scant data on this subject transplant recipients. This study assesses the relationship between protocol biopsies of grafts graft loss, renal Method A prospective observational included 530 recipients at Hospital...
Fusarium infections are very rare in HIV-infected patients, even patients advanced stages of immunosuppression. All the reported cases literature disseminated infection, and with poor outcomes despite prompt appropriate treatment. To best our knowledge, this is first report a localized infection keratoplasticum an HIV-positive patient, successfully treated combination antifungal therapy surgical removal focus.
The development of immune checkpoints from which tumor cells escape has revolutionized oncology in the past decade. However, its use is not indicated for solid organ transplant (SOT) recipients who wish to develop a state tolerance preserve graft. dysregulation system furthermore poses these patients at higher risk developing malignancies. Given lack therapeutic alternatives and vital associated with oncological disease, immunotherapy been some cases SOTR patients. Case reports confirm...
Abstract Background and Aims Anti-glomerular basement membrane (anti-GBM) disease is an aggressive rare glomerulopathy characterized by rapidly progressive loss of kidney function, leading to end stage (ESKD) in a significant amount cases. The main objective our study was determine whether anti-GBM titer correlated with the rate activity renal biopsy long-term survival patients anti-GBM, hence identifying who would potentially benefit from more intensive treatments. Method A retrospective...