Sabina Herrera
A5088119944- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Fungal Infections and Studies
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- HIV-related health complications and treatments
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
- Bone health and osteoporosis research
- Antibiotic Use and Resistance
- COVID-19 and healthcare impacts
- HIV/AIDS Research and Interventions
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- Cytomegalovirus and herpesvirus research
- Bone health and treatments
- Renal Transplantation Outcomes and Treatments
- Bone Metabolism and Diseases
- Bacterial Identification and Susceptibility Testing
- Neutropenia and Cancer Infections
- Pneumonia and Respiratory Infections
- Diabetes and associated disorders
- Antibiotics Pharmacokinetics and Efficacy
Hospital Clínic de Barcelona
2021-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021-2025
Universitat de Barcelona
2021-2025
Instituto de Salud Carlos III
2014-2024
Centro de Investigación Biomédica en Red
2022-2024
Hospital Universitario Ramón y Cajal
2019-2022
Instituto Ramón y Cajal de Investigación Sanitaria
2019-2022
University Health Network
2018-2021
Universidad de Alcalá
2019-2021
Barcelona Institute for Global Health
2021
Abstract In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID‐19 disease severity. The model explains why males are more to develop severe symptoms while children ostensibly resistant infection. Further, the difference in mortality rates among different ethnicities. Androgen is determined by genetic variants receptor. receptor regulates transcription transmembrane protease, serine 2 (TMPRSS2), which required SARS‐CoV‐2 infectivity. TMPRSS2...
Time to positivity (TTP) and differential TTP (DTP) emerge as diagnostic prognostic tools for bloodstream infections (BSI) though specific cut-off values need be determined each pathogen. Pseudomonas aeruginosa BSI (PAE-BSI) is of critical concern, particularly in immunocompromised patients, due high mortality rates. Catheter-related are a common cause, necessitating rapid accurate effective management (source-control). Unicentric retrospective observational study analyzing the utility best...
Recently published studies have found an impaired immune response after SARS-CoV-2 vaccination in solid organ recipients. However, most of these not assessed cellular responses liver and heart transplant We prospectively studied recipients eligible for vaccination. Patients with past history infection or detectable antibodies (IgM IgG) were excluded. IgM/IgG ELISpot against the S protein 4 weeks receiving second dose mRNA-1273 (Moderna) vaccine. Side effects, troponin I, tests anti-HLA...
Abstract Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio < 1 randomized either weekly fecal capsules or placebo for 8 weeks. Stool donors were rationally selected based their signatures. We report that transplantation (FMT) is safe, not related severe adverse events, and attenuates HIV-associated dysbiosis. FMT elicits...
Coronavirus disease 2019 (COVID-19) predisposes patients to bacterial and fungal superinfections due the impairment of immunological system. Among associated opportunistic infections, mucormycosis is one least frequent but with highest mortality. We describe two cases in kidney transplant recipients, while they were hospitalized for SARS-CoV-2 pneumonia, rhinosinusal musculoskeletal involvement, respectively.
Abstract Background The use of remdesivir has demonstrated a significant reduction in the time to recovery patients with COVID-19. However, impact on mortality is still controversial. Therefore, it necessary evaluate whether there specific subgroup whom an active antiviral therapy also reduces mortality. Methods Patients admitted for &gt;48 h our hospital SARS-CoV-2 confirmed or suspected infection from February 2020 2021 were retrospectively analysed. primary outcome study was at 30...
In the context of COVID-19 pandemic, we aimed to analyze epidemiology, clinical characteristics, risk factors for mortality and impact on outcomes solid organ transplant (SOT) recipients compared a cohort non patients, evaluating if transplantation could be considered factor mortality. From March May 2020, 261 hospitalized patients with pneumonia were evaluated, including 41 SOT recipients. Of these, thirty-two kidney recipients, 4 liver, 3 heart 2 combined kidney-liver transplants. Median...
: Streptococcus pyogenes (Group A Streptococcus, GAS) is a prevalent cause of community-acquired bacterial infections, with invasive GAS (iGAS) infections presenting severe morbimortality. Clindamycin generally used based on its antitoxin effect. This study investigates changes in iGAS incidence, clinical presentation, outcomes, and clindamycin resistance an adult cohort. Retrospective analysis S. episodes from tertiary hospital Barcelona (Spain) between 2015 2023. Pre-pandemic period...
We have previously reported that men with androgenetic alopecia (AGA) are more likely to present severe COVID-19 symptoms, potentially implicating androgen sensitivity as a risk factor for COVID-19.1-3 As such, we hypothesized 5-alpha-reductase inhibitors (5ARi) may reduce the severity of disease. To test this hypothesis, conducted retrospective cohort analysis on male subjects laboratory confirmed SARS-CoV-2 infection. The presented at one five outpatient clinics (Corpometria Institute...
Despite the scientific and human efforts to understand COVID-19, there are questions still unanswered. Variations in metabolic reaction SARS-CoV-2 infection could explain striking differences susceptibility risk of severe disease. Here, we used untargeted metabolomics examine novel pathways related COVID-19 clinical severity using capillary electrophoresis coupled a time-of-flight mass spectrometer (CE-TOF-MS) plasma samples. We included 27 patients with confirmed 29 healthcare workers...
ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen capable of causing severe infections in immunocompromised individuals, who often require prolonged antibiotic therapy. The emergence carbapenemase-producing P. has further complicated the management nosocomial infections, limiting therapeutic options. Cefiderocol recently emerged as a promising antipseudomonal agent, using bacterial iron transport system to gain entry into cell; however, there have been reports resistant...