A5013049685- Rheumatoid Arthritis Research and Therapies
- Gut microbiota and health
- Diet and metabolism studies
- Tryptophan and brain disorders
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Reproductive tract infections research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
Universidad Complutense de Madrid
2021-2022
Abstract Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio < 1 randomized either weekly fecal capsules or placebo for 8 weeks. Stool donors were rationally selected based their signatures. We report that transplantation (FMT) is safe, not related severe adverse events, and attenuates HIV-associated dysbiosis. FMT elicits...
While the intestinal microbiome seems a major driver of persistent immune defects in people with HIV (PWH), little is known about its fungal component, mycobiome. We assessed inter-kingdom mycobiome–bacteriome interactions, impact diet, and association innate adaptive immunity PWH on antiretroviral therapy. included 24 individuals 12 healthy controls. sequenced Internal Transcribed Spacer 2 amplicons, determined amplicon sequence variants, measured biomarkers blood relations diet. Compared...
While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living HIV (PWH) antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed two types patterns determined. We explored associations each pattern gut microbiota plasma inflammatory biomarkers. Results: appreciated patterns, Mediterranean-like (MEL) one Western-like (WEL). Compared to...
<h3>Background</h3> It has been seen that patients who achieve remission measured by DAS28 persist with subclinical synovitis on hands and toes evaluated ultrasound. In recent times stricter criteria as the CDAI, SDAI ACR EULAR Boolean have proposed. <h3>Objectives</h3> To evaluate diagnostic test ultrasound considered reference or gold standard in for DAS28. <h3>Methods</h3> We consecutive less than 2,6. Strict were applied. A rheumatologist specializing musculoskeletal ultrasound, was...
<h3>Background</h3> Currently, one of the main goals rheumatoid arthritis treatment is to attain remission. Stricter criteria, namely CDAI, SDAI ACR/EULAR Boolean have been proposed. Moreover, DAS28 criticized for exclusion foot joints assessment. However degree agreement that they with ultrasound findings in patienrs remission not well known. <h3>Objectives</h3> The aim our study evaluate between state as measured by different stricter criteria and absence activity assessed hands toes....
Methods: We included a cohort of patients with diagnosis early RA less than 2 years disease duration who not respond to MTX monotherapy, according medical judgment, and added step-up combination LEF. Data were collected every 3 months, including sociodemographic characteristics, functional status, activity treatment. The primary outcome was the time remission combined therapy, defined index 28 joints (DAS28). Combination treatment failure as achieving remission. Time assessed from date start...