A5059770355- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- HIV/AIDS drug development and treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- Diabetes, Cardiovascular Risks, and Lipoproteins
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Tryptophan and brain disorders
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Metabolomics and Mass Spectrometry Studies
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
Universidad de Alcalá
2016-2025
Hospital Universitario Ramón y Cajal
2016-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2016-2025
Instituto de Salud Carlos III
2022-2025
Centro de Investigación Biomédica en Red
2021-2024
University of California, San Francisco
2022-2024
San Francisco General Hospital
2022-2024
Instituto Cajal
2013-2024
MRC Biostatistics Unit
2024
University of Cambridge
2024
A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. subset of HIV-infected receiving effective antiretroviral therapy (ART) fails to normalize this ratio, even after they achieve normal CD4+ T cell counts. The immunologic clinical characteristics phenotype remain undefined. Using data from four distinct cohorts three trials, we show that a during otherwise ART (after CD4 count recovery above 500 cells/mm3) number immunological...
A low CD4/CD8 ratio has been identified in the general population as a hallmark of inmmunosenescence and surrogate all-cause mortality. We aimed to investigate treated HIV-infected individuals relationship between serious non-AIDS events.
The protein kinase C (PKC) agonist bryostatin-1 has shown significant ex-vivo potency to revert HIV-1 latency, compared with other latency reversing agents (LRA). safety of this candidate LRA remains be proven in treated HIV-1-infected patients.In pilot, double-blind phase I clinical-trial (NCT 02269605), we included aviraemic patients on triple antiretroviral therapy evaluate the effects two different single doses (10 or 20 μg/m) placebo.Twelve were included, four each arm. Bryostatin-1 was...
We explored the associations of CD4/CD8 ratio with markers immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children adolescents. inversion was associated higher frequencies activated, senescent activated/exhausted CD4+and CD8+ T-cells, a skewed phenotype from naive toward effector memory which persisted after multivariate analysis. Thus, may identify patients immunoactivation despite ART.
Objectives Inversion of the CD 4: 8 ratio (< 1) has been identified as a hallmark inmmunosenescence and an independent predictor mortality in general population. We aimed to assess association between markers age‐associated disease treated HIV ‐infected patients with good immunovirological response. Methods A cross‐sectional analysis was conducted 132 adults on antiretroviral therapy ( ART ), plasma RNA < 50 ‐1 copies/mL for at least 1 year, 4 count > 350 cells/μL age 65 years....
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to risk morbidity and mortality. Here, we identified a bystander mechanism that promotes CD8 cell activation expansion in untreated patients. Compared with healthy controls, patients have an population proliferating, granzyme B+, circulation. Vβ expression deep sequencing CDR3 revealed HIV-1 infection, cycling memory possess broad repertoire reflects the resting population. This suggests is driven by...
While changes in gut microbial populations have been described human immuno-deficiency virus (HIV)-infected patients undergoing antiretroviral therapy (ART), the mechanisms underlying contributions of bacteria and their molecular agents (metabolites proteins) to immune recovery remain unexplored. To study this, we examined active fraction microbiome, through examining protein synthesis accumulation metabolites inside bloodstream, 8 healthy controls 29 HIV-infected individuals (6 being...
Alopecia areata is a T-cell-mediated autoimmune disease with an unknown etiopathogenesis. Gut microbiota has been revealed as key modulator of systemic immunity.To determine whether patients affected by alopecia universalis present differences in gut bacteria composition compared healthy controls and investigate possible bacterial biomarkers the disease.We conducted cross-sectional study that involved 15 controls. microbiome subjects was analysed sequencing 16SrRNA stool samples. We searched...
Abstract Changes in the microbiota have been linked to persistent inflammation during treated HIV infection. In this pilot double-blind study, we study 30 HIV-infected subjects on antiretroviral therapy (ART) with a CD4/CD8 ratio < 1 randomized either weekly fecal capsules or placebo for 8 weeks. Stool donors were rationally selected based their signatures. We report that transplantation (FMT) is safe, not related severe adverse events, and attenuates HIV-associated dysbiosis. FMT elicits...
Abstract In the last decade, studies in persons with HIV (PWH) on antiretroviral therapy (ART) have shed light significance of persistently high CD8 counts and low CD4/CD8 ratios. A ratio reflects increased immune activation is associated an risk severe non-AIDS events. As a result, many clinicians now believe that can help monitoring, researchers report it as efficacy marker interventional studies. However, topic more complex. Recent not yielded unanimous conclusions ability to predict...
Abstract Background Information on the microbiome's human pathways and active members that can affect SARS-CoV-2 susceptibility pathogenesis in salivary proteome is very scarce. Here, we studied a unique collection of samples harvested from April to June 2020 unvaccinated patients. Methods We compared 10 infected hospitalized patients with severe ( n = 5) moderate coronavirus disease (COVID-19) uninfected individuals, including non-COVID-19 but susceptible individuals nonsusceptible...
Despite effective antiretroviral therapy, people with HIV (PWH) experience persistent systemic inflammation and increased morbidity mortality. Modulating the gut microbiome through fecal microbiota transplantation (FMT) represents a novel therapeutic strategy. We aimed to evaluate proteomic changes in inflammatory pathways following repeated, low-dose FMT versus placebo. This double-masked, placebo-controlled pilot study assessed impacts of weekly placebo treatment over 8 weeks on 29 PWH...
HIV-infected adults display increased cardiovascular disease, probably driven by inflammation and immune activation. These relationships have not been addressed in vertically children adolescents, a population at very high risk for long-term non-AIDS complications.Carotid intima media thickness (IMT) was measured cohort of adolescents healthy controls. C-reactive protein markers activation (CD38⁺HLA-DR⁺) senescence (CD28⁻CD57⁺) were determined.One hundred fifty patients 150 controls...
While nutritional interventions with prebiotics and probiotics seem to exert immunological effects, their clinical implications in human immunodeficiency virus (HIV)-infected subjects initiating antiretroviral therapy (ART) at advanced HIV disease remain unclear.This was a pilot multicenter randomized, placebo-controlled, double-blind study which 78 HIV-infected, ART-naive <350 CD4 T cells/μL or AIDS were randomized either daily PMT25341 (a mixture of synbiotics, omega-3/6 fatty acids amino...
Abstract Imbalances in gut bacteria have been associated with multiple diseases. However, whether there are disease-specific changes microbial metabolism remains unknown. Here, we demonstrate that human immunodeficiency virus (HIV) infection (n = 33) changes, at quantifiable levels, the of bacteria. These different than those observed patients auto-immune disease systemic lupus erythaematosus 18) and Clostridium difficile -associated diarrhoea 6). Using healthy controls as a baseline 16),...