A5060636579- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Child and Adolescent Health
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Pharmaceutical studies and practices
- Archaeological and Historical Studies
- Respiratory viral infections research
- Parasites and Host Interactions
- Mycobacterium research and diagnosis
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Ancient Mediterranean Archaeology and History
- Hepatitis C virus research
- Classical Antiquity Studies
- Cytomegalovirus and herpesvirus research
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Healthcare Systems and Technology
Hospital La Paz Institute for Health Research
2016-2024
Hospital Universitario de Gran Canaria Doctor Negrín
2008-2024
Pontificia Universidad Javeriana
2024
Hospital Universitario La Paz
2014-2023
Centro de Investigación Biomédica en Red
2021-2023
Universidad Autónoma de Madrid
1993-2023
Instituto de Salud Carlos III
1997-2022
Asociación Española de Urología
2010-2021
Biomedical Research and Innovation Institute of Cadiz
2021
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021
Abstract The aim of the study was to determine incidence viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in Spain. This a prospective study, collaboration with 17 Spanish hospitals, including 581 cases (CSF from all sera 280): meningitis (340), meningoencephalitis (91), (76), febrile syndrome (7), other neurological disorders (32), 35 without clinical information. CSF were assayed by PCR for enterovirus (EV), herpesvirus (herpes simplex [HSV], varicella‐zoster...
We explored the associations of CD4/CD8 ratio with markers immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children adolescents. inversion was associated higher frequencies activated, senescent activated/exhausted CD4+and CD8+ T-cells, a skewed phenotype from naive toward effector memory which persisted after multivariate analysis. Thus, may identify patients immunoactivation despite ART.
Abstract Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated severe acute respiratory coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features MIS-C in Spain. is potentially condition that presents recent SARS-CoV-2 infection.
Background. Combination antiretroviral therapy (cART) generally suppresses the replication of human immunodeficiency virus type 1 (HIV-1) but does not cure infection, because proviruses persist in stable latent reservoirs. It has been proposed that low-level proviral reservoirs might predict longer virologic control after discontinuation treatment. Our objective was to evaluate impact very early initiation cART and temporary treatment interruption on size HIV-1 reservoir vertically infected children.
Molecular epidemiological studies suggest that particular Mycobacterium tuberculosis strains have an enhanced capacity to spread within a community. One strain, the Beijing genotype, has been associated with outbreaks in number of communities throughout world. IS6110 restriction fragment length polymorphism (RFLP) analysis was performed on M. isolates from 566 721 patients (78.5%) diagnosed (TB) Gran Canaria Island 1993 1996, as well 35% 1991–1992 (85 strains). RFLP identification family...
The frequency and determinants of exogenous reinfection endogenous reactivation tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 1996, 962 cases were confirmed by culture. Drug susceptibility testing was performed on available bacterial isolates IS6110-based RFLP genotyping carried out. Twenty-three (2.4%) had two positive cultures separated at least 12 mo, 18 whom DNA for genotypic analysis. initial final from eight (44%)...
Future strategies aiming to achieve HIV-1 remission are likely target individuals with small reservoir size.We retrospectively investigated factors associated DNA levels in European, perinatally HIV-infected children starting antiretroviral therapy (ART) <6 months of age.Total was measured from 51 long-term suppressed aged 6.3 years (median) after initial viral suppression. Factors log10 total were analyzed using linear regression.At ART initiation, median [IQR] 2.3 [1.2-4.1] months, CD4% 37...
Abstract The aim of this transversal study was to describe the virological and immunological features HIV-infected youths transferred from pediatric adult care units since 1997 vs. non-transferred patients Madrid Cohort children adolescents in Spain. We included 106 184 under clinical follow-up 17 public hospitals by end December 2017. Virological outcomes were compared patients. ART drug resistance mutations HIV-variants analyzed all subjects with available pol genotypes and/or genotypic...
HIV-infected adults display increased cardiovascular disease, probably driven by inflammation and immune activation. These relationships have not been addressed in vertically children adolescents, a population at very high risk for long-term non-AIDS complications.Carotid intima media thickness (IMT) was measured cohort of adolescents healthy controls. C-reactive protein markers activation (CD38⁺HLA-DR⁺) senescence (CD28⁻CD57⁺) were determined.One hundred fifty patients 150 controls...
Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity long-term sequelae. However, there very few studies that assess the impact clinical spectrum pediatric TB (EPTB) in low-prevalence regions.Children <18 years age diagnosed with Madrid region (2005-2013) were reviewed. We compared epidemiology, characteristics performance diagnostic tests childhood pulmonary disease. performed a multivariate logistic...
Human parechoviruses (HPeV) have been recently recognized as important viral agents in paediatric infections. The aims of this study were to investigate the HPeV infection prevalence infants <1 month Spain and, secondly, analyse clinical and epidemiological characteristics infected patients compared with those by enterovirus (EV). Infants neurological or systemic symptoms included a multicentre prospective study. EV detection RT-PCR genotyping performed cerebrospinal fluids (CSF), sera...
The epidemiology and clinical association of enterovirus (EV) parechovirus (HPeV) infections, as well the type‐distribution‐according‐to‐age, were determined during a 4‐year study period in Spain. During 2010–2013, total 21,832 samples screened for EV detection frequency was 6.5% (1,430). Of EV‐negative samples, only 1,873 from 2011 to 2013 available HPeV testing. detected 42 (2%) them. Positive genotyped using PCR sequencing. infections occurred all age groups patients: neonates (17%),...
Paediatric HIV disease is now, in the era of highly effective antiretroviral therapy (HAART), a chronic treatable disease, yet across Europe significant and death still occur despite apparent immune reconstitution, much this attributable to vaccine-preventable disease. The complexities HIV-associated immunocompromise paediatric age range, profile time-course reconstitution produced by HAART initiated at various ages stages are poorly characterized. Available data point multiple causative...
Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging problem in the paediatric population worldwide with high mortality rates bloodstream infection (BSI). Objectives To evaluate predictors of 30 day CRE BSI a cohort. Methods A retrospective observational single-centre study (December 2005–August 2018) was conducted. Cases children 0 to 16 years were included. Microbiological identification (MALDI Biotyper) and antimicrobial susceptibility testing (Vitek2®...
We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and build a predictive model anticipate the probability of need for care.We conducted multicenter, prospective study SARS-CoV-2 infection 52 Spanish hospitals. The primary outcome was care. used multivariable Bayesian estimate needing care.The enrolled 350 from March 12, 2020, July 1, 2020: 292 (83.4%) 214 (73.7%) were considered have relevant COVID-19, whom 24.2% required Four major clinical...
Aim: To describe the impact of tenofovir disoproxil fumarate (TDF) use on renal function in HIV-infected pediatric patients. Design: It is a prospective, multicenter study. The setting consisted five third-level hospitals Spain. study was conducted patients aged 18 years and younger who had received TDF for at least 6 months. intervention based parameters by urine serum analyses. main outcome measures were results following months therapy. Results: Forty included (32 white 26 diagnosed with...
Background Antiretroviral treatment (ART) has contributed to increased life expectancy of HIV-1 infected children. In developed countries, an increasing number children reaching adulthood are transferred adult units. The objectives were describe the demographic and clinical features, ART history, antiviral drug resistance susceptibility in perinatally adolescents care units Spain from Madrid Cohort Methods Clinical, virological immunological features vertically patients HIV-infected analyzed...
Successful antiretroviral therapy (ART) has dramatically reduced mortality among HIV-infected children. However, there is growing concern about long-term effects associated to ART. The aim of this study was determine the prevalence metabolic abnormalities in a cohort perinatally adolescents and young adults identify factors.We present results from cross-sectional analysis including individuals 12 20 years age, prospective, longitudinal perinatally-acquired children, Madrid. Clinical...
Abstract We describe a case of virological failure during initial treatment with tenofovir disoproxil fumarate/emtricitabine/dolutegravir twice daily, concomitant rifampin staphylococcal infection, selection R263K + E157Q, and low plasma dolutegravir levels. Using together may require closer follow-up, and, if possible, levels should be monitored.
Summary We report the largest study on prevalence and distribution of HCV genotypes in Spain (2000‐2015), we relate them with clinical, epidemiological virological factors. Patients from 29 hospitals 10 autonomous communities (Andalusia, Aragon, Castilla‐Leon, Catalonia, Galicia, Canary Islands, Madrid Community, Valencian Murcia Region Basque Country) have been studied. Annual subtypes, as well gender, age, transmission route, HIV and/or HBV coinfection, treatment details were recorded....