Alfredo Tagarro
A5059535736- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- HIV/AIDS Research and Interventions
- Pneumonia and Respiratory Infections
- Kawasaki Disease and Coronary Complications
- HIV Research and Treatment
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 detection and testing
- Adolescent and Pediatric Healthcare
- Bacterial Infections and Vaccines
- Infectious Diseases and Tuberculosis
- HIV/AIDS drug development and treatment
- Autoimmune and Inflammatory Disorders Research
- Parvovirus B19 Infection Studies
- Diagnosis and treatment of tuberculosis
- COVID-19 and healthcare impacts
- Neonatal Health and Biochemistry
- COVID-19 diagnosis using AI
- Inflammasome and immune disorders
Hospital Universitario Infanta Sofía
2016-2025
Universidad Europea
2016-2025
Research Institute Hospital 12 de Octubre
2018-2025
Hospital Universitario del Henares
2022-2025
Madrid Health Service
2023-2025
Hospital General Universitario Gregorio Marañón
2024
Universidad Europea
2019-2023
Hospital Universitario 12 De Octubre
2018-2023
Centro de Investigación Biomédica en Red
2020-2022
Spanish Clinical Research Network
2018-2021
Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children Madrid, SpainAs the pandemic coronavirus disease spreads, new data emerge understanding improves.2][3] The epicenter epidemic has displaced to Europe.The first case Spain was declared on January 31, 2020, Madrid region February 27, 2020.Methods | With aim obtaining an overview proportion confirmed cases among those tested severity children, a registry performed from March 2, 16, by pediatricians 30 secondary tertiary...
Abstract Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated severe acute respiratory coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features MIS-C in Spain. is potentially condition that presents recent SARS-CoV-2 infection.
Future strategies aiming to achieve HIV-1 remission are likely target individuals with small reservoir size.We retrospectively investigated factors associated DNA levels in European, perinatally HIV-infected children starting antiretroviral therapy (ART) <6 months of age.Total was measured from 51 long-term suppressed aged 6.3 years (median) after initial viral suppression. Factors log10 total were analyzed using linear regression.At ART initiation, median [IQR] 2.3 [1.2-4.1] months, CD4% 37...
Recientemente se ha aprobado en Europa y España el uso de nirsevimab, un anticuerpo monoclonal (AcM) para la prevención enfermedad por virus respiratorio sincitial (VRS). Facilitar unas recomendaciones administración nirsevimab VRS. Para elaboración estas recomendaciones, decidió realizar una revisión crítica literatura, utilizando metodología Delphi GRADE. Se definió grupo expertos. realizaron tres rondas definir las preguntas, manifestarse a favor o contra, graduar recomendación, acuerdo...
After sporadic reports of post-treatment control HIV in children who initiated combination anti-retroviral therapy (cART) early, we prospectively studied 284 very-early-cART-treated from KwaZulu-Natal, South Africa, after vertical transmission to assess viremia. Eighty-four percent the achieved aviremia on cART, but persisting 36 or more months was observed only 32%. We that male infants have lower baseline plasma viral loads (P = 0.01). Unexpectedly, a subset (n 5) males maintained despite...
This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used prophylaxis among pediatric patients hospitalized 41 countries worldwide.Using standardized Antibiotic Resistance and Prescribing European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey at 226 hospitals from October 1 November 30, 2012.Overall, 17693 were surveyed 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242...
Abstract Objective Respiratory tract infections are among the most common causes of morbidity and mortality worldwide. Acute bronchiolitis (AB) is leading cause hospital admission infants. Clinical scores have proven to be inaccurate in predicting prognosis. Our aim was build a score based on findings lung ultrasound (LU) performed at admission, stratify patients risk needing respiratory support (non‐invasive invasive ventilation). Study design Prospective, multicenter study including...
A new paediatric multisystem inflammatory syndrome, linked to SARS-CoV-2 (MIS-Paed), has been described. The clinical picture is variable and associated with an active or recent infection due SARS-CoV-2. review of the existing literature by a multidisciplinary group specialists presented in this document. Later, they make recommendations on stabilisation, diagnosis, treatment syndrome.Se ha descrito un nuevo síndrome inflamatorio multisistémico pediátrico vinculado (SIM-PedS). Este cuadro...
We aimed to identify the spectrum of disease in children with COVID-19, and risk factors for admission paediatric intensive care units (PICUs). conducted a multicentre, prospective study SARS-CoV-2 infection 76 Spanish hospitals. included COVID-19 or multi-inflammatory syndrome (MIS-C) younger than 18 years old, attended during first year pandemic. enrolled 1200 children. A total 666 (55.5%) were hospitalised, 123 (18.4%) required PICU. Most frequent major clinical syndromes cohort mild...
Se ha descrito un nuevo síndrome inflamatorio multisistémico pediátrico vinculado a SARS-CoV-2. Este cuadro presenta una expresividad clínica variable y se asocia infección activa o reciente por En este documento revisa la literatura existente parte de grupo multidisciplinar especialistas pediátricos. Posteriormente, realizan recomendaciones sobre estabilización, diagnóstico tratamiento síndrome. A new paediatric multisystem inflammatory syndrome, linked to SARS-CoV-2, has been described....
Knowledge of thrombosis in children with SARS-CoV-2 is scarce. In this multicentre national cohort involving 49 hospitals, 4 patients out 537 infected developed a thrombotic complication (prevalence 0.7% (95% CI: 0.2% to 1.9%) the global and 1.1% 0.3% 2.8%) hospitalised patients). We describe their characteristics review other published paediatric cases. Three four were adolescent girls, only two cases had significant risk factors. cohort, D-dimer value was not specific enough predict...
We aimed to identify risk factors causing critical disease in hospitalized children with COVID-19 and build a predictive model anticipate the probability of need for care.We conducted multicenter, prospective study SARS-CoV-2 infection 52 Spanish hospitals. The primary outcome was care. used multivariable Bayesian estimate needing care.The enrolled 350 from March 12, 2020, July 1, 2020: 292 (83.4%) 214 (73.7%) were considered have relevant COVID-19, whom 24.2% required Four major clinical...
Fever without source (FWS) in infants is a frequent cause of consultation at the emergency department, and emergence SARS-CoV-2 could affect approach to those infants. The aim this study define clinical characteristics rates bacterial coinfections < 90 days with FWS as first manifestation infection. This cross-sectional under age positive SARS-CoV2 PCR nasopharyngeal swab/aspirate, attended departments 49 Spanish hospitals (EPICO-AEP cohort) from March 1 June 26, 2020. Three hundred...
Abstract Introduction Endemic coronaviruses have been found in acute bronchiolitis, mainly as a coinfecting virus. Severe respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has responsible for illness hospitalized children. The characteristics of patients with bronchiolitis not extensively described. Methods Cross‐sectional study and SARS‐CoV‐2 infection enrolled prospective multicenter cohort children COVID‐19 Spain from March 1, 2020 to February 28, 2021. Results Twelve 666 infected who...
Logistic regression (LR) is the most common prediction model in medicine. In recent years, supervised machine learning (ML) methods have gained popularity. However, there are many concerns about ML utility for small sample sizes. this study, we aim to compare performance of 7 algorithms 1-year mortality and clinical progression AIDS a cohort infants living with HIV from South Africa Mozambique. The data set (n = 100) was randomly split into 70% training 30% validation set. Seven (LR, Random...
Abstract Tumor-necrosis-factor-α inhibitors (anti-TNF-α) are associated with an increased risk of tuberculosis (TB) disease, primarily due to reactivation latent TB infection (LTBI). We assessed the performance parallel LTBI screening tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube assays (QFT-GIT) before anti-TNF-α treatment in children immune-mediated inflammatory disorders a low TB-burden setting. conducted multicenter cohort study involving 17 pediatric tertiary centers Spain....