A5073649059- Gut microbiota and health
- Infant Nutrition and Health
- Streptococcal Infections and Treatments
- Infectious Diseases and Tuberculosis
- Nosocomial Infections in ICU
- Hematological disorders and diagnostics
- HIV/AIDS Research and Interventions
- Restraint-Related Deaths
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Neuroscience of respiration and sleep
- Thermal Regulation in Medicine
- Cannabis and Cannabinoid Research
- HIV-related health complications and treatments
- Forensic Toxicology and Drug Analysis
- Poisoning and overdose treatments
- Orthopedic Infections and Treatments
- Epilepsy research and treatment
- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Prenatal Substance Exposure Effects
- Psychosomatic Disorders and Their Treatments
- Long-Term Effects of COVID-19
- Appendicitis Diagnosis and Management
- Traumatic Ocular and Foreign Body Injuries
Université de Toulouse
2015-2025
Inserm
2015-2024
Centre Hospitalier Universitaire de Toulouse
2015-2024
Société Française de Cardiologie
2024
Hôpital des Enfants
2013-2024
Hôpitaux Universitaires Paris-Ouest
2024
Assistance Publique – Hôpitaux de Paris
2024
Université Paris-Saclay
2024
Centre de recherche en Epidémiologie et Santé des Populations
2024
Research Institute Hospital 12 de Octubre
2024
The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which large proportion produces genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed rat model mimicking natural transmission E. mothers neonates. Genotoxic non-genotoxic were equally transmitted offspring stably across generations. DNA damage was only detected in neonates with genotoxic strains. Signs stress as...
ABSTRACT The intestinal barrier controls the balance between tolerance and immunity to luminal antigens. When this finely tuned equilibrium is deregulated, inflammatory disorders can occur. There a concomitant increase, in urban populations of developed countries, immune-mediated diseases along with shift Escherichia coli population from declining phylogenetic group A newly dominant B2, including commensal strains producing genotoxin called colibactin that massively colonized gut neonates....
Necrotizing enterocolitis (NEC) is a devastating condition in preterm infants due to multiple factors, including gut microbiota dysbiosis. NEC development poorly understood, the focus on severe (NEC-2/3).We studied microbiota, microbiome and metabolome of children with suspected (NEC-1).NEC-1 had higher abundance Streptococcus (second 10-days life) Staphylococcus (third species. NEC-1 showed evolution third life being most divergent, were associated different metabolomic signature than...
Objective: Most data published on adolescents living with HIV (ALH) have been collected before the large diffusion of second-generation integrase strand transfer inhibitors (INSTI) among pediatric population. We analyzed nationwide ANRS-MIE CO10 Pediatric cohort to assess changes over time in health and social outcomes French ALH. Design: The enrolled children born France since 1985 and, from 2005, diagnosed at ≤13 years, including those abroad if antiretroviral-naive first medical care...
Claudet, Isabelle MD, PhD; Marchand-Tonel, Claire CPN, Ricco, Lucas MD; Houzé-Cerfon, Charles-Henri Lang, Thierry Bréhin, Camille PhD Author Information
The success rate of non-operative treatment (NOT) acute uncomplicated appendicitis (AUA) in children varies from 65% to 95%. There are no recommendations on the appropriate antibiotic therapy.To determine clinical efficacy amoxicillin-clavulanic acid for NOT AUA children.Design: Cross-sectional study a single medical centre.Emergency department and Paediatric Visceral Surgery Children Hospital Toulouse, France.Patients 5-15 years old who were diagnosed with appendicitis, (1) With abdominal...
Abstract Background Bacterial infections (BIs) are widespread in ICUs. The aims of this study were to assess compliance with antibiotic recommendations and factors associated non-compliance. Methods We conducted an observational eight French Paediatric Neonatal ICUs antimicrobial stewardship programme (ASP) organised once a week for the most part. All children receiving antibiotics suspected or proven BI evaluated. Newborns < 72 h old, neonates 37 weeks, age ≥ 18 years under surgical...
In the European Union, record of cocaine-related seizures indicates an expanding supply. The purity has also been increasing. health impact these trends remains poorly documented, in particular, changes and clinical manifestations intoxication young children. We attempted to evaluate trend French pediatric admissions for cocaine intoxication/exposure over 11-year period (2010-2020).A retrospective, national, multicenter, study a cohort. All children less than 15 years age admitted...
To warn physicians and parents about the risk of macaque bites, we present two pediatric cases (a 4-year-old boy a 10-year-old girl) bites sustained while on holiday. The young developed febrile dermohypodermitis was hospitalized for IV antibiotic treatment. He received an initial antirabies vaccine still in holiday destination. Except local wound disinfection ointment, girl did not receive any specific treatment abroad. Both were negative simian herpes PCR. When travelling countries or...
To investigate the prevalence of infections by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses among children admitted to paediatric emergency departments (PEDs).From April July 2020, a prospective, multicentre cohort study was conducted in PEDs eight French university hospitals. Regardless reason for admission, nasopharyngeal swab sample from each child screened using reverse transcription polymerase chain reaction tests SARS-CoV-2 viruses. We determined...