A5104520626- Gastrointestinal motility and disorders
- Gut microbiota and health
- Diet and metabolism studies
- Probiotics and Fermented Foods
- Birth, Development, and Health
- Helicobacter pylori-related gastroenterology studies
- Infant Health and Development
- Digestive system and related health
- Reproductive System and Pregnancy
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Infant Nutrition and Health
- Dermatology and Skin Diseases
- Inflammatory Bowel Disease
- Clinical Nutrition and Gastroenterology
- Nutrition, Genetics, and Disease
- Agriculture Sustainability and Environmental Impact
- Nutritional Studies and Diet
- Barrier Structure and Function Studies
- Protein Hydrolysis and Bioactive Peptides
- Neuropeptides and Animal Physiology
- Phytoestrogen effects and research
- Mast cells and histamine
- Acupuncture Treatment Research Studies
- Asthma and respiratory diseases
Université de Toulouse
2013-2025
Toxalim Research Centre in Food Toxicology
2016-2025
Université Toulouse III - Paul Sabatier
2016-2025
École Nationale Vétérinaire de Toulouse
2017-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2007-2025
Institut National Polytechnique de Toulouse
2012-2023
Ecole d'Ingénieurs de PURPAN
1997-2022
Tokyo Medical and Dental University
2015
Institut National de la Recherche Agronomique
1991-2014
Nutrition & Santé (Spain)
2014
Abstract Background A probiotic formulation ( L actobacillus helveticus R0052 and B ifidobacterium longum R0175 combination, Probio'Stick ® ) displays anxiolytic‐like activity reduces apoptosis in the lymbic system animal models of depression. Based on hypothesis that modulation gut microbiota by this has beneficial effects brain stress conditions, we report a set probiotic‐evoked physiological, cellular, molecular events pretreated mice submitted to chronic psychological stress. Methods...
Background: psychological factors have long been implicated in the aetiology of irritable bowel syndrome often associated with abdominal pain. This work was designed to study, rats, influence partial restraint stress on cramps induced by rectal distension and determine role corticotropin releasing factor (CRF) mast cells degranulation this response. Methods: contractions were electromyographically recorded. Thirty minutes after or intracerebroventricular CRF, performed inflation a balloon...
Despite well-known intestinal epithelial barrier impairment and visceral hypersensitivity in irritable bowel syndrome (IBS) patients IBS-like models, structural physical changes the mucus layer remain poorly understood. Using a water avoidance stress (WAS) model, we aimed at evaluating whether 1) WAS modified gut permeability, sensitivity, mucin expression, biochemical structure of O-glycans, related properties, 2) Lactobacillus farciminis treatment prevented these alterations. Wistar rats...
Recent evidence suggests a role for increased colonic permeability and mucosal mast cell (MC) mediators on symptoms related to the irritable bowel syndrome (IBS). Whether allergic factors (AFs) are involved in pathophysiology of IBS is unclear. We addressed question possible influence an background symptoms.We assessed paracellular permeability, MCs counts, spontaneous release tryptase biopsy specimens 34 patients 15 healthy subjects. The severity was through self-reported questionnaires....
Background: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated effects pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. Objectives: We aimed to evaluate, mice, consequences chronic dietary mixture nontoxic doses, relevant consumers' assessment. Methods: A six commonly used France, i.e., boscalid,...
Mycobacterium tuberculosis mannose-capped lipoarabinomannan inhibits the release of proinflammatory cytokines by LPS-stimulated human dendritic cells (DCs) via targeting C-type lectin receptor DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN). With aim mimicking bioactive supramolecular structure lipoarabinomannan, we designed and synthesized a set poly(phosphorhydrazone) dendrimers grafted with mannose units, called mannodendrimers, that differed size number...
Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that probiotic formulation (Lactobacillus helveticus R0052 Bifidobacterium longum R0175) prevents chronic stress-mediated brain function abnormalities by attenuating the HPA response. Here, compared effect between different treatments on perception of visceral during colorectal distension (CRD) following stress consequences...
The colonic mucus barrier is commonly described as a continuous double layer covering the epithelium, separating microbiota from intestinal tissue. This model currently considered valid throughout colon. colon characterised by regional anatomo-functional specificities such presence and consistency of contents location. In this study, we organisation in proximal distal rodents histological FISH staining, taking into account aforementioned specificities. By using longitudinal sections imaging...
Abstract Irritable bowel syndrome (IBS) is a multifactorial disorder of the gut‐brain axis, characterized by visceral hypersensitivity (VH). Psychobiotics, through GABA synthesis, are good candidates to alleviate gastrointestinal discomfort. Here, we analyzed GABA‐producer Lactococcus lactis CNCM I‐5388 as an active‐enzyme postbiotic relieve VH mediated psychological stress. L. was inactivated ethanol while maintaining its glutamate decarboxylase (GAD) activity. This EtOH‐treated nonviable...
Hypersensitivity to rectal or colonic distension characterizes most patients with IBS and increased gut permeability has been described in post-dysenteric patients. However, no link established between these two events. The aim of this study was determine (i) whether chemical blockade stress-induced increase paracellular by 2,4,6 triaminopyrimidine (TAP) affects the concomitant hypersensitivity distension, (ii) role epithelial cell contraction hyperalgesia, using a myosin light chain kinase...
The use of superoxide dismutases (SODs) in inflammatory diseases is hampered by their short circulatory half-life. To determine whether a bacterial supply SOD into the colon might improve an experimental colitis, effects oral treatment with live recombinant lactic acid bacteria producing different amounts and those colonic infusion were compared. Wistar rats fitted catheter proximal through which TNBS was administered to induce colitis. Animals received continuous intracolonic bovine (40 U...
Elevated colonic luminal serine-protease (Ser-P) activity of diarrhea-predominant IBS (IBS-D) patients evokes a proteinase-activated receptor (PAR)-2-mediated hypersensitivity in mice. Despite similarly elevated Ser-P levels feces, with IBD exhibit visceral hypo- or normosensitivity to rectal distension, as opposed IBS-D. To explain these discrepancies we studied the effect infusion fecal supernatants from ulcerative colitis (UC) colorectal mechanical sensitivity mice and explored...
Abstract Background Fermented milk (FM) containing Bifidobacterium lactis CNCM I‐2494 and yogurt strains improves irritable bowel syndrome (IBS) symptoms in constipated IBS patients. In rats, stressful events exacerbate result the alteration of gut sensitivity permeability via epithelial cell cytoskeleton contraction. a stress model, we aimed at evaluating effect B. as pure strain or contained an FM product on visceral impact this intestinal barrier integrity. Methods Visceral was analyzed...
Luminal serine-proteases lead to increased colonic paracellular permeability and visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Other proteases, namely cysteine-proteases (CPs), increase airway by digesting epithelial tight junction proteins. In this study, we focused on constipation-predominant IBS (IBS-C) aimed (i) evaluate CP levels two cohorts of patients, (ii) test if IBS-C fecal supernatant (FSN) affects permeability, sensitivity after...
The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which large proportion produces genotoxin called colibactin. In order to analyze the short- and long-term effects resulting from such evolution, we developed rat model mimicking natural transmission E. mothers neonates. Genotoxic non-genotoxic were equally transmitted offspring stably across generations. DNA damage was only detected in neonates with genotoxic strains. Signs stress as...