A5042228333- Arctic and Russian Policy Studies
- French Urban and Social Studies
- Polar Research and Ecology
- Peroxisome Proliferator-Activated Receptors
- Indigenous Studies and Ecology
- China's Global Influence and Migration
- Canadian Identity and History
- Liver Disease Diagnosis and Treatment
- Transboundary Water Resource Management
- International Maritime Law Issues
- Water Governance and Infrastructure
- Cross-Border Cooperation and Integration
- Adipose Tissue and Metabolism
- Agriculture and Rural Development Research
- Island Studies and Pacific Affairs
- Mining and Resource Management
- Social Sciences and Governance
- Arctic and Antarctic ice dynamics
- Metabolism and Genetic Disorders
- Economic Zones and Regional Development
- European Socioeconomic and Political Studies
- Atmospheric chemistry and aerosols
- Water resources management and optimization
- Effects and risks of endocrine disrupting chemicals
- Diet, Metabolism, and Disease
Université Laval
2016-2025
Toxalim Research Centre in Food Toxicology
2016-2025
Université Toulouse III - Paul Sabatier
2016-2025
École Nationale Vétérinaire de Toulouse
2018-2025
Université de Toulouse
2014-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Centre de Géomatique du Québec
2016-2023
Ecole d'Ingénieurs de PURPAN
2022
China National Offshore Oil Corporation (China)
2018
Trent University
2018
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear expressed in tissues with high oxidative activity that plays central role metabolism. In this work, we investigated the effect of hepatocyte PPARα on non-alcoholic fatty liver disease (NAFLD).We constructed novel hepatocyte-specific knockout (Pparα(hep-/-)) mouse model. Using model, performed transcriptomic analysis following fenofibrate treatment. Next, which physiological challenges impact PPARα. Moreover, measured...
Changes in lifestyle are suspected to have strongly influenced the current obesity epidemic. Based on recent experimental, clinical, and epidemiological work, it has been proposed that some food contaminants may exert damaging effects endocrine metabolic functions, thereby promoting associated diseases such as nonalcoholic fatty liver disease (NAFLD). In this we investigated effect of one suspicious contaminant, bisphenol A (BPA), vivo. We used a transcriptomic approach male CD1 mice exposed...
Background: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated effects pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. Objectives: We aimed to evaluate, mice, consequences chronic dietary mixture nontoxic doses, relevant consumers' assessment. Methods: A six commonly used France, i.e., boscalid,...
Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required lipid oxidation in hepatocytes. Mice only lacking Pparα hepatocytes spontaneously develop steatosis without obesity aging. Steatosis can into non alcoholic steatohepatitis (NASH), which may progress irreversible damage, such fibrosis and hepatocarcinoma. While NASH appears major public health concern worldwide, it remains an...
In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a genomic and metabolic response required for homeostasis during fasting. This includes the biosynthesis of ketone bodies fibroblast growth factor 21 (FGF21). Here we show that in absence adipose triglyceride lipase (ATGL) adipocytes, body FGF21 production is impaired upon Liver gene expression analysis highlights set fasting-induced genes sensitive to both ATGL deletion adipocytes PPARα hepatocytes. Adipose...
Abstract Peroxisome proliferator-activated receptor-α (PPARα) is a major transcriptional regulator of lipid metabolism. It activated by diverse chemicals such as fatty acids (FAs) and regulates the expression numerous genes in organs displaying high FA catabolic rates, including liver. The role this nuclear receptor sensor whole dietary fat intake has been inferred, mostly from high-fat diet studies. To delineate its function under low conditions (4.8% w/w), we studied effects five regimens...
Objective We evaluated the influence of sex on pathophysiology non-alcoholic fatty liver disease (NAFLD). investigated diet-induced phenotypic responses to define sex-specific regulation between healthy and NAFLD identify influential pathways in different preclinical murine models their relevance humans. Design Different (high-fat diet, choline-deficient high-fat Western diet or supplemented with fructose glucose drinking water) were compared a control male female mice. performed metabolic...
SHP (small heterodimer partner, NR1I0) is an atypical orphan member of the nuclear receptor subfamily in that it lacks a DNA-binding domain. It mostly expressed liver, where binds to and inhibits function receptors. up-regulated by primary bile acids, through activation their farnesoid X receptor, leading repression cholesterol 7α-hydroxylase (CYP7α) expression, rate-limiting enzyme acid production from cholesterol. PXR (pregnane NR1I2) broad-specificity sensor recognizes wide variety...
In April 2002, aerosol characteristics have been recorded at Zhenbeitai (ZBT) near the city of Yulin (38°17′N, 109°43′E, Shaanxi province, China). One year earlier, ZBT had one continental supersites ACE‐Asia international experiment. spring, this site, located on southwestern fringe Mu Us desert, is crossing pathways followed by dust originating from main Chinese sources. During experiment a customized sampler has used. It specially designed to ensure best possible sampling isokineticity...
ABSTRACT With the melting of sea ice in Arctic, potential for higher shipping access has markedly changed. Shipping activity Arctic is increasing, including tourism and exploration activities, underlining need reliable communication monitoring. This article examines interactions between climate change, patterns cruise ship through Canada interest operators to increase their activities market region. Since 1995, summer pack offers possibilities increased this region while encouraging...
Liver physiology is circadian and sensitive to feeding insulin. Food intake regulates insulin secretion a dominant signal for the liver clock. However, how much contributes effect of on clock rhythmic gene expression remains be investigated. Insulin action partly depends changes in receptor (IR)-dependent expression. Here, we use hepatocyte-restricted deletion IR evaluate its role regulation oscillation as well programming adult mouse liver. We find that, absence IR, rhythmicity core-clock...
ABSTRACT Arctic sea routes have for long been of interest shipping because much shorter distances between the Atlantic and Pacific. Sea ice prevented real development significant traffic, but did not prevent research from trying to assess their economic viability. With melting in Arctic, this effort at modeling profitability has received a new impetus. However, conclusions these studies vary widely, depending on parameters chosen value. What can be said models, 1991 until 2013, what extent...
Olive oil consumption is beneficial for health as it associated with a decreased prevalence of cancer and cardiovascular diseases. Oleic acid is, by far, the most abundant component olive oil. Since can be made through de novo synthesis in animals, not an essential fatty acid. While has become clear that dietary oleic regulates many biological processes, signaling pathway involved these regulations remains poorly defined. In this work we tested impact acid-rich diet on hepatic gene...
ABSTRACT Maritime traffic is increasing in Arctic seas the context of climate change. The rapid melting sea ice led to widespread belief that was set expand rapidly, challenging Canadian and Russian-claimed sovereignties over their respective passage, underlining risk posed by such a risky but fragile environment. If projections on potential for medium term are probably exaggerated, nevertheless challenges adequacy regulatory framework.