A5100601273- Liver Disease Diagnosis and Treatment
- Bioinformatics and Genomic Networks
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Alzheimer's disease research and treatments
- Diet, Metabolism, and Disease
- Animal Genetics and Reproduction
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Muscle metabolism and nutrition
- Ferroptosis and cancer prognosis
- Alcohol Consumption and Health Effects
- Cardiovascular Function and Risk Factors
- Single-cell and spatial transcriptomics
- Chronic Lymphocytic Leukemia Research
- Peroxisome Proliferator-Activated Receptors
- Advanced Proteomics Techniques and Applications
- Cardiovascular Disease and Adiposity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gut microbiota and health
KTH Royal Institute of Technology
2017-2025
Science for Life Laboratory
2017-2025
National Institute on Alcohol Abuse and Alcoholism
2022-2025
National Institutes of Health
2022-2025
University of Gothenburg
2022-2025
Hamad bin Khalifa University
2024
Punjab Institute of Cardiology
2024
Riphah International University
2018-2024
University of Balochistan
2024
Guizhou University
2023
Modeling the cancer transcriptome Recent initiatives such as The Cancer Genome Atlas have mapped genome-wide effect of individual genes on tumor growth. By unraveling genomic alterations in tumors, molecular subtypes cancers been identified, which is improving patient diagnostics and treatment. Uhlen et al. developed a computer-based modeling approach to examine different types nearly 8000 patients. They provide an open-access resource for exploring how expression specific influences...
Single-cell RNA analysis has been integrated with spatial protein profiling to create a single–cell type map of human tissues.
Alzheimer's disease (AD) is associated with metabolic abnormalities linked to critical elements of neurodegeneration. We recently administered combined activators (CMA) the AD rat model and observed that CMA improves AD-associated histological parameters in animals. promotes mitochondrial fatty acid uptake from cytosol, facilitates oxidation mitochondria, alleviates oxidative stress.
Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 and analyze blood including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies immune cell profiling, complemented gut microbiota composition routine clinical chemistry. Overall, our results show high variation between across different readouts, while intra-individual baseline low....
COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including microbiome. To decipher hepatic steatosis (HS) pathogenesis excluding critical confounding variants diabetes, 56 heterogenous MAFLD patients are characterized generating multiomics data oral gut metagenomics as well plasma metabolomics inflammatory proteomics...
Significance Statement This study sheds light on the central role of adenine nucleotide translocase 2 (ANT2) in pathogenesis obesity-induced CKD. Our data demonstrate that ANT2 depletion renal proximal tubule cells (RPTCs) leads to a shift their primary metabolic program from fatty acid oxidation aerobic glycolysis, resulting mitochondrial protection, cellular survival, and preservation function. These findings provide new insights into underlying mechanisms CKD have potential be translated...
BACKGROUND: Cholesterol is critical for mitochondrial membrane structure and function. Given the emergence of mitochondria as a key factor in pathogenesis heart failure, cholesterol homeostasis may be crucial maintaining properties thus cardiac We previously showed that CM- Pcsk9 –/– mice (mice with cardiomyocyte-specific deletion PCSK9 [proprotein convertase subtilisin-kexin type 9]) have impaired cardiomyocyte bioenergetics function, paralleled by accumulation an increased number...
To better understand the health benefits of lifelong exercise in humans, we conduct global skeletal muscle transcriptomic analyses long-term endurance- (9 men, 9 women) and strength-trained (7 men) humans compared with age-matched untrained controls 8 women). Transcriptomic analysis, Gene Ontology, genome-scale metabolic modeling demonstrate changes pathways related to prevention diseases, particularly endurance training. Our data also show prominent sex differences between that these are...
Sarcomas are malignancies of mesenchymal origin that occur in bone and soft tissues. Many chemo- radiotherapy resistant, thus conventional treatments fail to increase overall survival. Natural Killer (NK) cells exert anti-tumor activity upon detection a complex array tumor ligands, but this has not been thoroughly explored the context sarcoma immunotherapy. In study, we investigated NK cell receptor/ligand immune profile primary human explants. Analysis tumors from 32 patients identified...
Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose tissue and skeletal muscle to examine the effects acquired obesity among 49 BMI-discordant monozygotic twin pairs. Overall, appears be more affected by excess body weight than muscle. In heavier co-twins, we observe a transcriptional pattern downregulated mitochondrial pathways both tissues upregulated inflammatory tissue. tissue,...
Objective We evaluated the influence of sex on pathophysiology non-alcoholic fatty liver disease (NAFLD). investigated diet-induced phenotypic responses to define sex-specific regulation between healthy and NAFLD identify influential pathways in different preclinical murine models their relevance humans. Design Different (high-fat diet, choline-deficient high-fat Western diet or supplemented with fructose glucose drinking water) were compared a control male female mice. performed metabolic...
The clinical outcome and disease severity in coronavirus 2019 (COVID-19) are heterogeneous, the progression or fatality of cannot be explained by a single factor like age comorbidities. In this study, we used system-wide network-based system biology analysis using whole blood RNA sequencing, immunophenotyping flow cytometry, plasma metabolomics, single-cell-type metabolomics monocytes to identify potential determinants COVID-19 at personalized group levels. Digital cell quantification...
Non-alcoholic fatty liver disease (NAFLD) is recognized as a manifestation of metabolic syndrome, accompanied with excessive fat accumulation in the and other vital organs. Ectopic was previously associated negative effects at systemic local level human body. Thus, we aimed to identify assess predictive capability novel potential biomarkers for ectopic depots non-diabetic men NAFLD, using inflammation-associated proteome, lipidome metabolome. Myocardial hepatic triglycerides were measured...
Biological networks provide new opportunities for understanding the cellular biology in both health and disease states. We generated tissue specific integrated (INs) liver, muscle adipose tissues by integrating metabolic, regulatory protein-protein interaction networks. also human co-expression (CNs) 46 normal 17 cancers to explore functional relationships between genes as well their with biological functions, investigate overlap physical interactions provided CNs INs, respectively. These...
COVID-19 has caused millions of deaths globally, yet the cellular mechanisms underlying various effects disease remain poorly understood. Recently, a new analytical platform for comprehensive analysis plasma protein profiles using proximity extension assays combined with next generation sequencing been developed, which allows multiple proteins to be analyzed simultaneously without sacrifice on accuracy or sensitivity.We patients (n = 50) mild and moderate symptoms by comparing levels in...
It is essential to reveal the associations between various omics data for a comprehensive understanding of altered biological process in human wellness and disease. To date, very few studies have focused on collecting exhibiting multi-omics single database. Here, we present iNetModels, an interactive database visualization platform Multi-Omics Biological Networks (MOBNs). This describes clinical chemistry, anthropometric parameters, plasma proteomics, metabolomics, as well metagenomics oral...
Myocardial infarction (MI) promotes a range of systemic effects, many which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, adipose) mouse model (induced by ligating left ascending coronary artery) sham-operated mice. We performed genome-wide transcriptomic analysis on tissue samples obtained 6- 24 hr post or sham operation. By generating tissue-specific biological networks, observed:...
Abstract Background There is a need for functional genome-wide annotation of the protein-coding genes to get deeper understanding mammalian biology. Here, new strategy introduced based on dimensionality reduction and density-based clustering whole-body co-expression patterns. This has been used explore gene expression landscape in pig, we present map all major pig tissues organs. Results An open-access ( www.rnaatlas.org ) presented 350 samples across 98 well-defined divided into 44 tissue...
Cardiovascular diseases (CVDs) are the leading cause of death among elderly people. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator cholesterol metabolism. Herein, we investigated role PCSK9 in age-related CVD. Both humans and rats, blood level correlated positively with increasing age development cardiovascular dysfunction. Age-related fatty degeneration liver tissue serum levels rat model, while nonalcoholic disease functional impairment. Network analysis...