A5015225256- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Congenital Heart Disease Studies
- Cardiovascular and exercise physiology
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Heart Failure Treatment and Management
- Cardiac Arrhythmias and Treatments
- ECG Monitoring and Analysis
- Cardiovascular Disease and Adiposity
- Sports injuries and prevention
- Artificial Intelligence in Healthcare
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Machine Learning in Healthcare
- Cardiovascular Health and Disease Prevention
- Transplantation: Methods and Outcomes
- Phonocardiography and Auscultation Techniques
- Elasticity and Material Modeling
- Radiomics and Machine Learning in Medical Imaging
- Bioinformatics and Genomic Networks
Semmelweis University
2016-2025
Robert Wood Johnson University Hospital
2024
Rutgers, The State University of New Jersey
2022-2024
Johnson University
2022-2024
Pázmány Péter Catholic University
2022-2024
Cedars-Sinai Medical Center
2024
IRCCS Istituto Auxologico Italiano
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
St. Antonius Ziekenhuis
2023
Amsterdam University Medical Centers
2023
Our aim was to develop a machine learning (ML)-based risk stratification system predict 1-, 2-, 3-, 4-, and 5-year all-cause mortality from pre-implant parameters of patients undergoing cardiac resynchronization therapy (CRT).
Evidence has shown the independent prognostic value of right ventricular (RV) function, even in patients with left-sided heart disease. The most widely used imaging technique to measure RV function is echocardiography; however, conventional 2-dimensional (2D) echocardiographic assessment unable leverage same clinical information that 3-dimensional (3D) echocardiography-derived ejection fraction (RVEF) can provide.
BACKGROUND: Right ventricular (RV) function has a well-established prognostic role in patients with severe mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER) and is typically assessed using echocardiography-measured tricuspid annular plane systolic excursion. Recently, deep learning model been proposed that accurately predicts RV ejection fraction (RVEF) from 2-dimensional echocardiographic videos, similar diagnostic accuracy as 3-dimensional imaging. This study...
•Global RV function is determined by different motion components.•Longitudinal, radial, and anteroposterior may be of comparable significance.•Age other anthropometric factors correlate with deformation pattern.•Elderly individuals show a distinct pattern. BackgroundGlobal right ventricular (RV) the interplay components related to myofiber architecture, relative importance these still not thoroughly characterized. The aims this study were quantify contributions longitudinal, global examine...
The functional adaptation of the right ventricle (RV) to different degrees left ventricular (LV) dysfunction remains be clarified. We sought (1) assess changes in RV contraction pattern associated with reduction LV ejection fraction (EF) and (2) analyze whether assessment longitudinal, radial, anteroposterior motion components total RVEF adds prognostic value.Consecutive patients left-sided heart disease who underwent clinically indicated transthoracic echocardiography were enrolled a...
Conventional echocardiographic parameters such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and free-wall longitudinal strain (FWLS) offer limited insights into the complexity of right ventricular (RV) function, while 3D echocardiography-derived RV ejection fraction (RVEF) enables a comprehensive assessment. We investigated discordance between TAPSE, FAC, FWLS, RVEF in function grading associated outcomes.
Three major mechanisms contribute to right ventricular (RV) pump function: (i) shortening of the longitudinal axis with traction tricuspid annulus towards apex; (ii) inward movement RV free wall; (iii) bulging interventricular septum into and stretching wall over septum. The relative contribution aforementioned function may change in different pathological conditions.Our aim was develop a custom method separately assess extent longitudinal, radial anteroposterior displacement walls quantify...
Measurement of systolic and diastolic function in animal models is challenging by conventional non-invasive methods. Therefore, we aimed at comparing speckle-tracking echocardiography (STE)-derived parameters to the indices left ventricular (LV) pressure–volume (PV) analysis detect cardiac dysfunction rat type-1 (T1DM) type-2 (T2DM) diabetes mellitus. Rat T1DM (induced 60 mg/kg streptozotocin, n = 8) T2DM (32-week-old Zucker Diabetic Fatty rats, 7) corresponding control animals (n 5 8,...
We sought to investigate the correlation between speckle-tracking echocardiography (STE)-derived myocardial work (MW) and invasively measured contractility in a rat model of athlete's heart. also assessed MW elite athletes explored its association with cardiopulmonary exercise test (CPET)-derived aerobic capacity.Sixteen rats underwent 12-week swim training program were compared controls (n = 16). STE was performed assess global longitudinal strain (GLS), which followed by invasive...
Abstract Aims While left ventricular (LV) adaptation to regular, intense exercise has been thoroughly studied, data concerning the right (RV) mechanical changes and their continuum with athletic performance are scarce. The aim of this study was characterize biventricular morphology function relation sex, age, sports classes in a large cohort elite athletes using three-dimensional (3D) echocardiography. Methods results Elite, competitive (n = 422) healthy, sedentary volunteers 55) were...
Cardiovascular diseases (CVDs) are the leading cause of death among elderly people. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important regulator cholesterol metabolism. Herein, we investigated role PCSK9 in age-related CVD. Both humans and rats, blood level correlated positively with increasing age development cardiovascular dysfunction. Age-related fatty degeneration liver tissue serum levels rat model, while nonalcoholic disease functional impairment. Network analysis...
•LV contractility and afterload are both major determinants of LS LSSr.•In hemodynamic overload–induced HF, altered.•Thus, under these conditions, LSSr reflect VAC rather than mere contractility. BackgroundLongitudinal strain (LS) is a sensitive marker systolic function. Recent findings suggest that myocardial loading conditions determine LS. The aim this study was to investigate whether reflects the connection cardiac (termed ventriculoarterial coupling [VAC]) in rat models heart failure...
Three main mechanisms contribute to global right ventricular (RV) function: longitudinal shortening, radial displacement of the RV free wall (bellows effect), and anteroposterior shortening (as a consequence left contraction). Since importance these may vary in different cardiac conditions, technology being able assess their relative influence on pump function could help clarify pathophysiology mechanical adaptation chamber. Previously, we have introduced our 3D echocardiography (3DE)-based...
Background: The Olympic preparation of athletes has been highly influenced by COVID and post-COVID syndrome. As the complex screening is essential for safe successful sports, we aimed to repeat 2019-year sports cardiology Swim Team before Olympics compare results non-COVID athletes. Methods: Patient history, electrocardiogram, laboratory tests, body composition analysis, echocardiography, cardiopulmonary exercise test (CPET) were performed. We used time-ranking points swimming performance....
Abstract Aims While global longitudinal strain (GLS) is considered to be a sensitive marker of left ventricular (LV) function, it significantly influenced by loading conditions. We hypothesized that myocardial work index (GMWI), novel LV may show better correlation with load‐independent markers contractility in rat models pressure‐induced or volume overload‐induced heart failure. Methods and results Male Wistar rats underwent either transverse aortic constriction (TAC; n = 12) aortocaval...
Assessment of right ventricular (RV) function using conventional echocardiography might be inadequate as the radial motion RV free wall is often neglected. Our aim was to quantify longitudinal and components three-dimensional (3D) in heart transplant (HTX) recipients. Fifty-one HTX patients stable cardiovascular condition without history relevant rejection episode or chronic allograft vasculopathy 30 healthy volunteers were enrolled. end-diastolic (EDV) volume total ejection fraction (TEF)...
Abstract Aims The PREPARE‐MVR study (PRediction of Early PostoperAtive Right vEntricular failure in Mitral Valve Replacement/Repair patients) sought to investigate the alterations right ventricular (RV) contraction pattern patients undergoing mitral valve replacement/repair (MVR) and explore associations between pre‐operative RV mechanics early post‐operative dysfunction (RVD). Methods results We prospectively enrolled 42 (63 ± 11 years, 69% men) open‐heart MVR. Transthoracic...
Right ventricular (RV) three-dimensional (3D) strains can be measured using novel 3D RV analytical software (ReVISION). Our objective was to investigate the prognostic value of strains.We retrospectively selected patients who underwent both echocardiography (3DE) and cardiac magnetic resonance from January 2014 October 2020. 3DE datasets were analyzed with speckle tracking ReVISION software. The primary end point a composite events, including death, heart failure hospitalization, or...
Echocardiography is a cornerstone of cardiovascular care but relies on expert interpretation and manual reporting from series videos. We propose an artificial intelligence (AI) system, PanEcho, to automate echocardiogram with multi-task deep learning. To develop evaluate the accuracy PanEcho comprehensive set 39 echocardiographic labels measurements transthoracic echocardiography (TTE). This study represents development retrospective, multi-site validation AI system. was developed using...