A5035787348- Pesticide Exposure and Toxicity
- Genomics, phytochemicals, and oxidative stress
- Carcinogens and Genotoxicity Assessment
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Pesticide and Herbicide Environmental Studies
- Agriculture and Rural Development Research
- Effects and risks of endocrine disrupting chemicals
- Nutritional Studies and Diet
- Birth, Development, and Health
- Pancreatic function and diabetes
- Synthesis and biological activity
- Reproductive System and Pregnancy
- Environmental Toxicology and Ecotoxicology
- Innovative Approaches in Technology and Social Development
- Toxic Organic Pollutants Impact
- Phytochemicals and Antioxidant Activities
- Consumer Attitudes and Food Labeling
- Pregnancy and Medication Impact
- Garlic and Onion Studies
- Flavonoids in Medical Research
- Hormonal and reproductive studies
- Gut microbiota and health
Toxalim Research Centre in Food Toxicology
2016-2025
École Nationale Vétérinaire de Toulouse
2005-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Université de Toulouse
2011-2025
Université Toulouse III - Paul Sabatier
2013-2024
Institut National de la Recherche Agronomique
2001-2014
Xenobe Research Institute
1997-2005
Weatherford College
1998
Unité de recherche sur les maladies cardiovasculaires et métaboliques
1992
Background: Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated effects pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets. Objectives: We aimed to evaluate, mice, consequences chronic dietary mixture nontoxic doses, relevant consumers' assessment. Methods: A six commonly used France, i.e., boscalid,...
In hepatocytes, peroxisome proliferator-activated receptor α (PPARα) orchestrates a genomic and metabolic response required for homeostasis during fasting. This includes the biosynthesis of ketone bodies fibroblast growth factor 21 (FGF21). Here we show that in absence adipose triglyceride lipase (ATGL) adipocytes, body FGF21 production is impaired upon Liver gene expression analysis highlights set fasting-induced genes sensitive to both ATGL deletion adipocytes PPARα hepatocytes. Adipose...
Abstract Sulforaphane (SFN) is a natural micronutrient found in cruciferous vegetables that has been shown to possess antitumoral properties carcinogen-treated rats. In vitro, SFN regulates phase II enzymes, cell cycle, and apoptosis. the present study, we investigated relationship between induction of apoptosis cycle arrest HT29 human colon carcinoma cells. previously published data, significant increase G2/M observed SFN-treated cells was associated with increased cyclin B1 protein levels....
Objective We evaluated the influence of sex on pathophysiology non-alcoholic fatty liver disease (NAFLD). investigated diet-induced phenotypic responses to define sex-specific regulation between healthy and NAFLD identify influential pathways in different preclinical murine models their relevance humans. Design Different (high-fat diet, choline-deficient high-fat Western diet or supplemented with fructose glucose drinking water) were compared a control male female mice. performed metabolic...
In Burkina Faso, as in most Sahelian countries, the failure to follow good agricultural practices coupled with poor soil and climate conditions locust control context lead high environmental contaminations pesticide residues. Thus, consumers being orally exposed a combination of multiple residues through food water intake, digestive tract is tissue susceptible be directly these contaminants. The aim our work was compare vitro impact five desert pesticides (Deltamethrin DTM, Fenitrothion FNT,...
Liver physiology is circadian and sensitive to feeding insulin. Food intake regulates insulin secretion a dominant signal for the liver clock. However, how much contributes effect of on clock rhythmic gene expression remains be investigated. Insulin action partly depends changes in receptor (IR)-dependent expression. Here, we use hepatocyte-restricted deletion IR evaluate its role regulation oscillation as well programming adult mouse liver. We find that, absence IR, rhythmicity core-clock...
Glucosinolates hydrolysis products are attracting increasing attention since many studies have suggested that they may be involved in the anticarcinogenic property of cruciferous vegetables. In this study, we show diindolylmethane (DIM) and sulforaphane, produced during glucobrassicin glucoraphanin, respectively, exert a dose-dependent cytotoxicity on human colon adenocarcinoma HT29 cells. Moreover, these able to inhibit quiescent cells re-enter cell cycle. Interestingly, our results clearly...
Abstract Background Some pesticides, used in large quantities current agricultural practices all over Europe, are suspected of adverse effects on human reproductive health (breast and prostate cancers), through mechanisms endocrine disruption possible carcinogenic properties, as observed settings. However, evidence dietary pesticide exposure breast cancer (BC) is lacking for the general population. We aimed to assess associations between pesticides BC risk among postmenopausal women...
Abstract Background The gut microbiota–intestine–liver relationship is emerging as an important factor in multiple hepatic pathologies, but the sensors and effectors of microbial signals are not well defined. Results By comparing publicly available liver transcriptomics data from conventional vs. germ-free mice, we identified pregnane X receptor (PXR, NR1I2) transcriptional activity strongly affected by absence microbes. Microbiota depletion using antibiotics Pxr +/+ vs -/- C57BL/6J...
Studies focusing on dietary pesticides in population-based samples are scarce and little is known about potential mixture effects. We aimed to assess associations between pesticide exposure profiles Type 2 Diabetes (T2D) among NutriNet-Santé cohort participants.Participants completed a Food Frequency Questionnaire at baseline, assessing conventional organic food consumption. Exposures 25 active substances used European Union were estimated using the Chemisches und Veterinäruntersuchungsamt...