A5018404813- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Genetic Associations and Epidemiology
- Advanced Proteomics Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Nutrition, Genetics, and Disease
- Cardiac Imaging and Diagnostics
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Lipoproteins and Cardiovascular Health
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Vagus Nerve Stimulation Research
- Bariatric Surgery and Outcomes
- Genetics and Physical Performance
- Nicotinic Acetylcholine Receptors Study
- Protease and Inhibitor Mechanisms
- Cardiovascular Function and Risk Factors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Security and Health in Diverse Populations
- Cancer, Lipids, and Metabolism
University of Gothenburg
2010-2025
Region Västra Götaland
2020-2025
Sahlgrenska University Hospital
2011-2025
National Academy of Medicine
2007-2024
AstraZeneca (Sweden)
2010-2014
Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight decreases overall In fact, many observational suggest that reduction mortality.The prospective, controlled Swedish Obese Subjects study involved 4047 obese subjects. Of these subjects, 2010 underwent bariatric surgery (surgery group) and 2037 received conventional treatment (matched control group). We report on mortality...
A database provides information on the relative abundances and locations of human proteins that are predicted to be secreted.
The gut is inhabited by a densely populated ecosystem, the microbiota, that established at birth. However, succession which different bacteria are incorporated into microbiota still relatively unknown. Here, we analyze from 471 Swedish children followed birth to 5 years of age, collecting samples after 4 and 12 months 3 age as well their mothers using 16S rRNA gene profiling. We also compare an adult population. Genera follow colonization patterns during establishment where...
Temporal dynamics of the gut microbiota potentially limit identification microbial features associated with health status. Here, we used whole-genome metagenomic and 16S rRNA gene sequencing to characterize intra- inter-individual variations composition functional potential a disease-free Swedish population (n = 75) over one year. We found that 23% total compositional variance was explained by intra-individual variation. The degree variability negatively abundance Faecalibacterium...
Increased visceral fat, as opposed to subcutaneous/gluteal, most strongly relates key metabolic dysfunctions including insulin resistance, hepatic steatosis, and inflammation. Mesenteric fat hypertrophy in patients with Crohn's disease experimental rodent models of gut inflammation suggest that impaired barrier function increased leakage gut-derived antigens may drive lipid deposition. The aim this study was determine whether intestinal permeability is associated adiposity healthy humans....
Abstract An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 and analyze blood including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies immune cell profiling, complemented gut microbiota composition routine clinical chemistry. Overall, our results show high variation between across different readouts, while intra-individual baseline low....
Abstract The need for precision medicine approaches to monitor health and disease makes it important develop sensitive accurate assays proteome profiles in blood. Here, we describe an approach plasma profiling based on proximity extension assay combined with next generation sequencing. First, analyze the variability of between within healthy individuals a longitudinal wellness study, including influence genetic variations levels. Second, follow patients newly diagnosed type 2 diabetes before...
The present study aims to describe accelerometer-assessed physical activity (PA) patterns and fulfillment of PA recommendations in a large sample middle-aged men women, differences between subgroups socio-demographic, socio-economic, lifestyle-related variables. A total 27 890 (92.5% participants, 52% aged 50-64 years) women with at least four days valid hip-worn accelerometer data (Actigraph GT3X+, wGT3X+ wGT3X-BT) from the Swedish CArdioPulmonary bioImage Study, SCAPIS, were included. In...
Abstract Pathogenic variants in the EMD gene cause X-linked Emery–Dreifuss muscular dystrophy type 1 (EDMD1), typically presenting with joint contractures and skeletal muscle atrophy, followed by atrial arrhythmias, cardiac conduction defects, dilatation. Although an association isolated dilated cardiomyopathy (DCM) has been suggested, evidence is currently insufficient to verify gene-disease association. We investigated causality of a missense variant, c.23C>G, p.Ser8Trp, large family...
To identify genes predominantly expressed in omental adipocytes, microarray expression profiles from 33 human tissues or cell types were analyzed, using an algorithm developed for identification of transcripts a certain tissue. Both known adipocyte-specific and more unexpected among the 28 identified. validate approach, adipocyte three these genes, acute-phase serum amyloid A (A-SAA), aquaporin 7, transport secretion protein-2.2, was compared with 17 other by real-time PCR. The unexpectedly...
Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered bone as osteonectin, is a mediator of collagen deposition promotes fibrosis. Adipose tissue has recently been found to be linked with metabolic dysregulation. Therefore, we tested the hypothesis that SPARC human adipose influenced by glucose metabolism adipokines.Serum biopsies were obtained from morbidly obese nondiabetic subjects undergoing bariatric surgery lean control for analysis markers, SPARC,...
In the era towards precision medicine, we here present individual specific autoantibody signatures of 193 healthy individuals. The self-reactive IgG are stable over time in a way that each profile is recognized longitudinal sampling. reactivity an antigen array comprising 335 protein fragments, representing 204 human proteins with potential relevance to autoimmune disorders, was measured plasma samples from This analysis resulted unique barcodes for were maintained one year's time. profiles,...
Cell death-inducing DNA fragmentation factor-alpha-like effector A (CIDEA) could be a potential target for the treatment of obesity via modulation metabolic rate, based on findings that CIDEA inhibits brown adipose tissue uncoupling process in rodents.Our objects were to investigate putative link between and basal rate humans elucidate further role human obesity.We have explored gene expression two different studies: cross-sectional population-based study assessing body composition (Mölndal...
Changes in energy intake have marked and rapid effects on metabolic functions, some of these may be due to changes adipocyte gene expression that precede alterations body weight.The aim the study was identify genes regulated by caloric independent weight.Obese subjects given a very low-caloric diet followed gradual reintroduction ordinary food healthy subjected overfeeding were investigated. Adipose tissue biopsies taken at multiple time-points, measured DNA microarray. Genes obese...
The human immune system varies extensively between individuals, but variation within individuals over time has not been well characterized. Systems-level analyses allow for simultaneous quantification of many interacting components and the inference global regulatory principles. Here, we present a longitudinal, systems-level analysis in 99 healthy adults 50 to 65 years age sampled every third month 1 year. We describe structure interindividual characterize extreme phenotypes along principal...
Context: We have previously identified nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1 (NQO1), an enzyme involved in the protection against oxidative stress, as a gene predominantly expressed human adipocytes. Studies mice deficient NQO1 activity suggest that may also play important role metabolism. Objective: The aim of this study was to explore expression and regulation adipose tissue (AT) isolated Patients Results: high adipocytes verified AT by real-time PCR. DNA...
The human plasma proteome is important for many biological processes and targets diagnostics therapy. It therefore of great interest to understand the interplay genetic environmental factors determine specific protein levels in individuals gain a deeper insight importance architecture related individual variability proteins during adult life.We have combined whole-genome sequencing, multiplex profiling, extensive clinical phenotyping longitudinal 2-year wellness study 101 healthy with...
Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about and reported diversity of phenotypes, descriptions human health have been far less elaborate.To provide insights into longitudinal protein signatures well-being, we profiled blood plasma collected over one year from 101 clinically healthy individuals using multiplexed antibody assays. After applying validation scheme, utilized > 700 profiles for...
Patients with type 2 diabetes have an increased risk of death and cardiovascular events people or prediabetes been found to atherosclerotic burden in the coronary carotid arteries. This study will estimate cross-sectional prevalence atherosclerosis arteries individuals diabetes, compared normoglycaemic a large population-based cohort.The 30,154 participants, 50-64 years, were categorized according their fasting glycaemic status self-reported data as normoglycaemic, prediabetes, previously...
Reduced lung function is associated with cardiovascular mortality, but the relationships atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured function, emphysema, coronary CT angiography, calcium, carotid plaques and ankle-brachial index in 29,593 men women aged 50-64 years. results were confirmed using 2-sample Mendelian randomization. Lower emphysema more atherosclerosis, these attenuated after adjustment for risk factors. Lung was not 14,524...