A5031530589- Gut microbiota and health
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Probiotics and Fermented Foods
- Diet, Metabolism, and Disease
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Bariatric Surgery and Outcomes
- Dietary Effects on Health
- Epigenetics and DNA Methylation
- Botanical Research and Applications
- Food Security and Health in Diverse Populations
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
- Infant Nutrition and Health
- Diabetes and associated disorders
- Food composition and properties
- Nutritional Studies and Diet
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Gastroesophageal reflux and treatments
- Cancer, Hypoxia, and Metabolism
University of Würzburg
2021-2024
Universitätsklinikum Würzburg
2023
Dalian Institute of Chemical Physics
2018-2023
Chinese Academy of Sciences
2018-2023
University of Chinese Academy of Sciences
2023
University of Gothenburg
2010-2021
Sahlgrenska University Hospital
2010-2017
Wallenberg Wood Science Center
2014
TiFN
2008-2009
Wageningen University & Research
2008
Highlights•The gut microbiota contributes to phenotypic differences in mice fed lard or fish oil•Mice lacking MyD88 TRIF are protected against WAT inflammation•Microbial-derived factors induce CCL2 adipocytes through TLR4, MyD88, and TRIF•Microbial-induced enhances macrophage accumulation WATSummaryDietary lipids may influence the abundance of circulating inflammatory microbial factors. Hence, inflammation white adipose tissue (WAT) induced by dietary be partly dependent on their interaction...
Bariatric surgery is currently the most effective procedure for treatment of obesity. Given role gut microbiota in regulating host metabolism and adiposity, we investigated long-term effects bariatric on microbiome patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty matched weight fat mass loss. The two surgical procedures induced similar durable changes that were not dependent body index resulted altered levels fecal circulating metabolites compared with obese...
Abstract Gut mucosal microbes evolved closest to the host, developing specialized local communities. There is, however, insufficient knowledge of these communities as most studies have employed sequencing technologies investigate faecal microbiota only. This work used shotgun metagenomics biopsies explore microbial communities’ compositions terminal ileum and large intestine in 5 healthy individuals. Functional annotations genome-scale metabolic modelling selected species were then identify...
The gut is inhabited by a densely populated ecosystem, the microbiota, that established at birth. However, succession which different bacteria are incorporated into microbiota still relatively unknown. Here, we analyze from 471 Swedish children followed birth to 5 years of age, collecting samples after 4 and 12 months 3 age as well their mothers using 16S rRNA gene profiling. We also compare an adult population. Genera follow colonization patterns during establishment where...
Maintenance of body temperature in cold-exposed animals requires induction thermogenesis and management fuel. Here, we demonstrated that reducing ambient attenuated diet-induced obesity (DIO), which was associated with increased iBAT a plasma bile acid profile similar to germ-free mice. We observed marked shift the microbiome composition at phylum family levels within 1 day acute cold exposure after 4 weeks 12°C. Gut microbiota characterized by Adlercreutzia, Mogibacteriaceae,...
Abstract Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction T2D are underweight or have normal weight. Several studies linked gut microbiome to and T2D, but role microbiota lean individuals having unique clinical characteristics remains unclear. A metagenomic targeted metabolomic analysis is conducted 182 abdominally obese without newly diagnosed T2D. The abundance Akkermansia muciniphila ( A. ) significantly decreases than not comparison Its correlates...
Abstract Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight or obesity, we test whether resistant starch (RS) as supplement influences obesity-related outcomes. Here, show RS supplementation 8 weeks can help to achieve weight loss (mean −2.8 kg) and improve insulin resistance individuals excess body...
Carbohydrates, including starches, are an important energy source for humans, and known their interactions with the microbiota in digestive tract. Largely, those thought to promote human health. Using 16S ribosomal RNA (rRNA)-based stable isotope probing (SIP), we identified starch-fermenting bacteria under colon-like conditions. To of TIM-2 vitro model colon 7.4 g l(-1) [U-(13)C]-starch was added. extracted from lumen samples after 0 (control), 2, 4 8 h subjected density-gradient...
The gut microbiota influences the development and progression of metabolic diseases partly by metabolism bile acids (BAs) modified signaling through farnesoid X receptor (FXR). In this study, we aimed to determine how human metabolizes murine BAs affects FXR in colonized mice. We germ-free mice with cecal content from a mouse donor or feces euthanized after short-term (2 weeks) long-term (15 colonization. analyzed BA composition expression target genes ileum liver. found that differed...
The structure of the human gastrointestinal microbiota can change during pregnancy, which may influence gestational metabolism; however, a mechanism action remains unclear. Here we observed that in wild-type (WT) mice relative abundance Actinobacteria and Bacteroidetes increased pregnancy. Along with these changes, short-chain fatty acids (SCFAs), are mainly produced through gut fermentation, significantly changed both cecum peripheral blood throughout gestation mice. SCFAs recognized by G...
The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host are difficult to study because bacteria interact in complex food webs concert the host, and many of not yet characterized. To reduce complexity, we colonize mice a simplified intestinal (SIM) composed ten sequenced strains isolated from complementing pathways metabolize dietary fibers. We feed SIM one three diets (chow [fiber rich], high-fat/high-sucrose, or...
Mutations in isocitrate dehydrogenase (IDH) 1 are high-frequency events low-grade glioma and secondary glioblastoma, IDH1 mutant gliomas vulnerable to interventions. Metabolic reprogramming is a hallmark of cancer. In this study, comprehensive metabolism investigation clinical specimens was performed explore its specific metabolic real microenvironment. Massive alterations from glycolysis lipid were identified the tissue when compared wild-type glioma. Of note, tricarboxylic acid (TCA) cycle...
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by microbiota, suggested to be a driving force development insulin resistance obesity. Here, we report that bacterial DNA is present mesenteric adipose tissue obese but otherwise healthy human subjects. Pyrosequencing 16S rRNA genes revealed from Gram-negative species Ralstonia was most...
Abstract Purpose We previously showed that short-term intervention with barley kernel bread (BKB) improved glucose tolerance. However, tolerance was not in a subset of individuals (non-responders) who were characterized by low Prevotella / Bacteroides ratio. The purpose the present study to investigate if baseline ratio can be used stratify metabolic responders and non-responders dietary fiber (DF). Methods Fecal samples collected from 99 healthy humans BMI < 28 kg/m 2 between 50 70 years...
Network analysis of large metagenomic datasets generated by current sequencing technologies can reveal significant co-occurrence patterns between microbial species a biological community. These be analyzed in terms pairwise combinations all comprising Here, we construct network for abundant encompassing the three dominant phyla found human gut. This was followed an vitro evaluation predicted microbe-microbe co-occurrences, where chose pairs Bifidobacterium adolescentis and Bacteroides...