A5074544689- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Neuropeptides and Animal Physiology
- Renal function and acid-base balance
- Ion Transport and Channel Regulation
- Renin-Angiotensin System Studies
- Diabetes Treatment and Management
- Eosinophilic Esophagitis
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Veterinary Pharmacology and Anesthesia
- Esophageal Cancer Research and Treatment
- Anesthesia and Sedative Agents
- Obesity and Health Practices
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Esophageal and GI Pathology
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Sahlgrenska University Hospital
2015-2025
Region Västra Götaland
2022-2025
University of Gothenburg
2015-2024
Institute of Clinical Research
2022
Uppsala University
1986-2004
Swedish Research Council
1995-2000
Knut and Alice Wallenberg Foundation
2000
American Gastroenterological Association
2000
Swedish Society of Medicine
1995-1998
Medical Research Council
1995-1998
Bariatric surgery is currently the most effective procedure for treatment of obesity. Given role gut microbiota in regulating host metabolism and adiposity, we investigated long-term effects bariatric on microbiome patients randomized to Roux-en-Y gastric bypass or vertical banded gastroplasty matched weight fat mass loss. The two surgical procedures induced similar durable changes that were not dependent body index resulted altered levels fecal circulating metabolites compared with obese...
In Brief Objective: To evaluate the physiologic importance of satiety gut hormones. Background: Controversy surrounds role hormones in control appetite. Bariatric surgery remains most effective treatment option for obesity, and are implicated reduction appetite weight after Roux-en-Y gastric bypass. Methods: We correlated peptide YY (PYY) glucagon-like 1 (GLP-1) changes within first week bypass with also evaluated hormone responses patients good or poor loss Finally, we inhibited then food...
Androgens exert important effects both in androgen-responsive tissues and the intestinal tract. To determine impact of gut microbiota (GM) on androgen metabolism, we measured unconjugated (free) glucuronidated levels contents from small intestine, with a low bacterial density, cecum colon, high density. Using specific, sensitive gas chromatography-tandem mass spectrometry method, detected testosterone (T) dihydrotestosterone (DHT) content mice sexes, whereas distal intestine observed...
Considerable urinary excretion of dopamine metabolites indicates that large amounts are produced in unknown locations the body. This study assessed contribution mesenteric organs (gastrointestinal tract, spleen, and pancreas) to total body production humans examined presence rate-limiting enzyme for synthesis, tyrosine hydroxylase, gastrointestinal tissues. Blood sampled from an artery portal hepatic veins eight subjects arterial renal venous sites other was analyzed plasma concentrations...
The first druglike selective angiotensin II AT2 receptor agonist (21) with a Ki value of 0.4 nM for the and >10 μM AT1 is reported. Compound 21, bioavailability 20−30% after oral administration half-life estimated to 4 h in rat, induces outgrowth neurite cells, stimulates p42/p44mapk, enhances vivo duodenal alkaline secretion Sprague−Dawley rats, lowers mean arterial blood pressure anesthetized, spontaneously hypertensive rats. Thus, peptidomimetic 21 exerts similar biological response as...
Angiotensin II acts through two major receptors: AT1-R and AT2-R. It is known that the stimulation of mediates vasoconstriction, cell proliferation fibrosis, aldosterone release inflammatory response but, although AT2-R thought to promote vasodilation anti-inflammatory effects, its real in-vivo functions are still unclear. The aim this study was investigate effects specific selective on pathological events occurring in spontaneously hypertensive stroke-prone rats (SHRSPs).SHRSPs who were fed...
Objective To compare two bariatric surgical principles with regard to effects on blood pressure and salt intake. Background In most patients surgery induces a sustained weight loss reduced cardiovascular risk profile but the long-term effect is uncertain. Methods Cohort study data from prospective, controlled Swedish Obese Subjects (SOS) involving 480 primary health care centres 25 departments in Sweden. treated non-surgical methods (Controls, n = 1636 1132 at 2 y 10 follow up, respectively)...
Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate difference BA concentration at baseline and response a meal stimulus between type 2 diabetes mellitus (T2DM) matched normoglycaemic group.A cross-sectional 12 patients with known T2DM controls compared fractions after overnight fast following standard meal.The group had higher glucose (P < 0.001), but total BA, glycine...
Background and Aims Gastric bypass results in greater weight loss than Vertical banded gastroplasty (VBG), but the underlying mechanisms remain unclear. In addition to effects on energy intake two bariatric techniques may differentially influence expenditure (EE). rats increases postprandial EE enough result elevated over 24 hours. This study aimed investigate alterations after gastric VBG humans. Methods Fourteen women from a randomized clinical trial between (n = 7) were included. Nine...
Objective. Exogenous bile acid (BA) administration is associated with beneficial metabolic effects very similar to those seen after Roux-en-Y gastric bypass (RYGB) surgery. Re-routing of into a biliopancreatic limb simultaneous exclusion food occurs RYGB, subsequent increased fasting plasma BAs. The study assessed and post-prandial BA response before 15 months RYGB. Material methods. prospective recruited 63 obese individuals (43 females), aged 43 (36–56) [median (IQR)] years. Blood samples...
Cholera toxin (CT) enters and intoxicates host cells after binding cell surface receptors via its B subunit (CTB). We have recently shown that in addition to the previously described partner ganglioside GM1, CTB binds fucosylated proteins. Using flow cytometric analysis of primary human jejunal epithelial granulocytes, we now show correlates with expression Lewis X (LeX) glycan. This is competitively blocked by oligosaccharides fucose-binding lectins. LeX glycan vitro when this moiety linked...
Roux-en-Y gastric bypass (LRYGB) has weight-independent effects on glycemia in obese type 2 diabetic patients, whereas sleeve gastrectomy (LSG) is less well characterized. This study aims to compare early and later weight-dependent glycemic of LRYGB LSG. Eighteen 15 LSG patients were included the study. Glucose, insulin, GLP-1, GIP levels monitored during a modified 30 g oral glucose tolerance test before surgery days, 3 weeks, 12 months after surgery. Patients self-monitored weeks...
This study using sampling of blood from the portal vein, in addition to arterial and hepatic sites, estimate separately spillovers norepinephrine mesenteric organs liver seven patients undergoing upper abdominal surgery. Conventional measurements venous plasma provided a measure net hepatomesenteric NE spillover (403 pmol/ml) that indicated 13% contribution these total body into systemic (3,071+/-518 pmol/min). The was much lower than (1,684+/-418 (212+/-72 pmol/min) considerable combined...
Roux-en-Y gastric bypass surgery is the most efficient treatment of morbid obesity, but mechanisms action are still poorly understood. The aim this study was to explore Roux-limb mucosa after surgery, focusing upon basic morphology and inflammation.Jejunal mucosal samples from were gathered eight patients at time 6-8 months postsurgery. Histological evaluation inflammation morphometric investigations performed, cell proliferation assessed using immunohistochemistry inflammatory markers...
The Roux-Y gastric bypass (RYGBP) is an effective weight-reducing procedure but the involved mechanisms of action are obscure. Roux limb intestinal segment that following surgery primary recipient for food intake. aims study were to explore mechanosensory and biomechanical properties make correlations with preferred meal size. Ten patients participated examined preoperatively, 6 weeks 1 year after RYGBP. Each subject ingested unrestricted amounts a standardized weight was recorded. On...
Experiments were performed in chloralosed cats with ligated adrenals redording of arterial blood pressure, heart rate and gastric volume, the latter a balloon method. Electric activation peripheral cut vagus at low high intensity induced excitatory relaxatory responses, respectively. Hexamethonium blocked stimulation‐bound bradycardia but now intensities resistant to a‐ fi‐adrenergic blocking agents naloxone sensitive atropine. Heating intact vagus, selectively activate thin afferents,...