A5032629734- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Fibroblast Growth Factor Research
- Diet, Metabolism, and Disease
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Digestive system and related health
- Birth, Development, and Health
- Pancreatic function and diabetes
- Platelet Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Extracellular vesicles in disease
- Lipid metabolism and disorders
- Gut microbiota and health
- Metabolism, Diabetes, and Cancer
- Vagus Nerve Stimulation Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Sphingolipid Metabolism and Signaling
- Cell death mechanisms and regulation
University of Michigan
2015-2025
Ann Arbor Center for Independent Living
2025
Cincinnati Children's Hospital Medical Center
2013-2021
Indiana University – Purdue University Indianapolis
2011
University of Tsukuba
2007-2010
Czech Academy of Sciences, Institute of Physiology
2008
Our objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG).High fat diet (HFD)-induced obese C57Bl/6 mice were randomized VSG, Sham operation (Sham), with pair feeding VSG (Sham-PF), or nonsurgical controls (Naïve). All on HFD until sacrifice. Mice observed postsurgery and data for body weight, composition, metabolic parameters, serum acid level composition collected. Further gene expression by mRNA-seq RT-PCR analysis...
Abstract Bariatric surgery elevates serum bile acids. Conjugated acid administration, such as tauroursodeoxycholic (TUDCA), improves insulin sensitivity, whereas short-circuiting circulation through ileal interposition in rats raises TUDCA levels. We hypothesized that bariatric outcomes could be recapitulated by short circuiting the normal enterohepatic circulation. established a model wherein male obese underwent either diversion (BD) or Sham (SH) surgery. The BD group had catheter inserted...
To evaluate the effect of thrombopoietin on liver regeneration after hepatectomy and antifibrosis under conditions cirrhosis in rats.We revealed that platelets induced by administration promote normal liver.Seventy percent was carried out rats, which were subsequently divided into 4 groups: (1) group without any treatment, (2) (LC) group, (3) combined (LC+TPO) (4) thrombopoietin, antiplatelet serum (LC+TPO+APS) group. Growth kinetics growth factors analyzed. Liver fibrotic area activation...
Fibroblast growth factor 15/19 (FGF15/19, mouse/human ortholog) is expressed in the ileal enterocytes of small intestine and released postprandially response to bile acid absorption. Previous reports FGF15-/- mice have limited our understanding gut-specific FGF15's role metabolism. Therefore, we studied endogenous gut-derived FGF15 acid, cholesterol, glucose, energy balance. We found that circulating levels FGF19 were reduced individuals with obesity comorbidities, such as type 2 diabetes...
Pregnancy is characterized by physiological adjustments in the maternal compartment. In this investigation, influence of pregnancy on liver was examined CD-1 mice. Dramatic changes were observed size during pregnancy. Livers doubled weight from non-pregnant state to day 18 The pregnancy-induced hepatomegaly a event growth confirmed DNA content increase and detection hepatocyte hyperplasia hypertrophy. Growth initiated following implantation peaked at parturition. expression and/or activities...
Objective Bile acids (BA) are elevated after vertical sleeve gastrectomy (VSG) and farnesoid-X-receptor (FXR) is critical to the success of murine VSG. BA downregulate hepatic lipogenesis by activating FXR-small heterodimer partner (SHP) pathway. The role SHP in fatty liver disease improvement VSG was tested. Methods Wild type (WT), transgenic (SHP-Tg), knockout (SHP-KO) high-fat diet (HFD) fed mice underwent either or Sham surgery. Body weight, level composition, steatosis, metabolism gene...
<h3>Objective</h3> Surgical interventions that prevent nutrient exposure to the duodenum are among most successful treatments for obesity and diabetes. However, these highly invasive, irreversible often carry significant risk. The duodenal-endoluminal sleeve (DES) is a flexible tube acts as barrier nutrient-tissue interaction along duodenum. We implanted this device in Zucker Diabetic Fatty (ZDF) rats gain greater understanding of duodenal exclusion on glucose homeostasis. <h3>Design</h3>...
Saturated fatty acids activate the c-Jun NH₂-terminal kinase (JNK) pathway, resulting in chronic low-grade inflammation and development of insulin resistance. Mixed-lineage 3 (MLK3) is a mitogen-activated protein (MAP3K) that mediates JNK activation response to saturated vitro; however, exact mechanism for diet-induced vivo not known. Here, we have used MLK3-deficient mice examine role MLK3 saturated-fat diet model obesity. MLK3-KO fed high-fat enriched medium-chain 16 wk had decreased body...
Abstract Background/Purpose Platelets develop tissue repair and promote liver regeneration. We investigated whether platelets prevented acute damage after extended hepatectomy in pigs. Methods Thrombocytosis was induced by the following two methods; afterwards 80% performed In first method, pigs received administration of thrombopoietin [TPO (+) group], they were compared with a control group (−) group]. second splenectomy [Sp theywere another Platelet counts, biochemical examination blood,...
Background & Aims: Obesity induction in mice requires high-fat diet exposure. While hepatic steatosis develops, progression to inflammation and fibrosis, as humans, prolonged exposure additional dietary factors. Immunosuppression at room temperature may slow this progression. We evaluated thermoneutrality's effect on MASH development using a fibrosis-inducing (GAN) diet. Methods: Mice were fed either or chow housed thermoneutrality. groups sacrificed monthly from 4 7 months. Serum...
Abstract Background and Aim: Platelets provide many functions in the body, especially to liver. The purpose of this study is investigate effect thrombocytosis with acute hepatitis induced by anti‐Fas antibody its mechanism. Methods: Acute was administration normal thrombocytotic C57BL6J mice. For thrombocytosis, thrombopoietin; PEG‐rHuMGDF injected 5 days before just prior antibody. To mechanisms, hepatocyte cell line (AML12) sinusoidal endothelial (M1) were apoptosis staurosporine. They...
In the absence of an intact fibroblast growth factor 15 (FGF15) signaling pathway, murine vertical sleeve gastrectomy results in weight loss without all its anticipated metabolic benefits. FGF15 increased intestinal bile acid levels and hepatolipotoxicity.
To investigate the effect of high fructose diet on ultrastructure and content hepatic mitochondria, we randomized 6-8 weeks old male C57Bl6/J mice to ad lib chow or high-fat-high-fructose (HF2) for 32 weeks. HF2-fed gained more weight, had higher plasma alanine aminotransferase, fasting glucose levels increased triglyceride at all time points compared chow-fed mice. lower mitochondrial nuclear DNA ratio average surface area number mitochondria expression endoplasmic reticulum stress marker...