A5044755277- Gut microbiota and health
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Effects and risks of endocrine disrupting chemicals
- Neonatal Respiratory Health Research
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Cutaneous lymphoproliferative disorders research
- T-cell and Retrovirus Studies
- Tryptophan and brain disorders
- Helicobacter pylori-related gastroenterology studies
- Barrier Structure and Function Studies
- Birth, Development, and Health
- Digestive system and related health
- Gastroesophageal reflux and treatments
- Metabolomics and Mass Spectrometry Studies
- Vitamin D Research Studies
- Pediatric health and respiratory diseases
- CAR-T cell therapy research
- Neuroendocrine regulation and behavior
- Pain Management and Opioid Use
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Immunotoxicology and immune responses
- Pediatric Pain Management Techniques
Kyowa Kirin (France)
2020-2023
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
Karolinska Institutet
2012-2017
AstraZeneca (United Kingdom)
2017
Institut National de la Recherche Agronomique
2012-2014
Toxalim Research Centre in Food Toxicology
2011-2014
The intestinal microbiota helps to maintain the integrity of blood-brain barrier in fetal and adult mice.
Abstract Background A probiotic formulation ( L actobacillus helveticus R0052 and B ifidobacterium longum R0175 combination, Probio'Stick ® ) displays anxiolytic‐like activity reduces apoptosis in the lymbic system animal models of depression. Based on hypothesis that modulation gut microbiota by this has beneficial effects brain stress conditions, we report a set probiotic‐evoked physiological, cellular, molecular events pretreated mice submitted to chronic psychological stress. Methods...
Bisphenol A (BPA), a chemical estrogen widely used in the food-packaging industry and baby bottles, is recovered human fluids (0.1-10 nM). Recent studies have reported that BPA hormonally active at low doses, emphasizing debate of risk for health. Estrogen receptors are expressed colon, although major route exposure food, effects on gut received no attention. We first examined endocrine disrupting potency colonic paracellular permeability (CPP), experimental colitis, visceral sensitivity...
Oestradiol modulates paracellular permeability and tight junction (TJ) function in endothelia reproductive tissues, but whether the ovarian hormones cycle affect pathway intestinal epithelium remains unclear. Oestrogen receptors (ERs) are expressed epithelial cells, oestradiol regulates formation. We examined effects of oestrous stage, benzoate (EB), progesterone (P) on colonic (CPP) female rat, EB affects expression TJ proteins rat colon human cell line Caco-2. In cyclic rats, CPP was...
Abstract The ligand-induced transcription factor, aryl hydrocarbon receptor (AhR) is known for its capacity to tune adaptive immunity and xenobiotic metabolism—biological properties subject regulation by the indigenous microbiome. objective of this study was probe postulated microbiome-AhR crosstalk whether such an axis could influence metabolic homeostasis host. Utilising a systems-biology approach combining in-depth 1 H-NMR-based metabonomics (plasma, liver skeletal muscle) with microbiome...
Visceral pain and hypothalamic-pituitary-adrenal axis (HPA) dysregulation is a common characteristic in irritable bowel syndrome (IBS) patients. Previously, we reported that probiotic formulation (Lactobacillus helveticus R0052 Bifidobacterium longum R0175) prevents chronic stress-mediated brain function abnormalities by attenuating the HPA response. Here, compared effect between different treatments on perception of visceral during colorectal distension (CRD) following stress consequences...
The food contaminant bisphenol A (BPA) is pointed out as a risk factor in development of allergy and intolerance, two adverse reactions increasing worldwide. We evaluated the consequences perinatal exposure to low doses BPA on immune-specific response antigen ovalbumin (OVA) at adulthood. Perinatal (0.5, 5, or 50 μg/kg/d) from 15th day gravidity pups weaning resulted an increase anti-OVA IgG titers all dosages OVA-tolerized rats, 5 μg/kg/d OVA-immunized rats compared control treated with...
Glucocorticoids (GC) contribute to human intestine ontogeny and accelerate gut barrier development in preparation birth. Rat is immature at birth, high intestinal GC sensitivity during the first two weeks of life resembles that premature infants. This makes suckling rats a model investigate postpartum impact maternal separation (MS)-associated release preterm babies, whether may shape MS effects gut. A 4 hours-MS applied once postnatal day (PND)10 enhanced plasma corticosterone male female...
Efficacy and safety of mogamulizumab, a monoclonal antibody directed against C-C chemokine receptor 4, were demonstrated in previous multinational clinical trial conducted patients with previously treated cutaneous T-cell lymphoma (CTCL): Sézary syndrome (SS) or Mycosis Fungoides (MF).The real-world French OMEGA study aimed to describe effectiveness tolerability mogamulizumab adult CTCL, overall according the disease (SS MF).In this retrospective study, for SS MF included from 14 expert...
Pro-inflammatory cytokines like macrophage migration inhibitory factor (MIF), IL-1β and TNF-α predominate in inflammatory bowel diseases (IBD) TNBS colitis. Increased levels of serine proteases activating protease-activated receptor 2 (PAR-2) are found the lumen colonic tissue IBD patients. PAR-2 activity pro-inflammatory impair epithelial barrier, facilitating uptake luminal aggressors that perpetuate inflammation visceral pain. Soy extracts contain phytoestrogens (isoflavones) protease...
Naloxegol, an oral once-daily peripherally acting mu-opioid receptor antagonist, is indicated for the treatment of opioid-induced constipation (OIC) with inadequate response to laxative(s), in cancer and non-cancer patients. This study mainly aimed assess real-life conditions efficacy safety naloxegol pain patients evolution their quality life.A non-interventional, 4-week follow-up was conducted 24 French oncology centers between 2018 2019. Eligible were aged ≥ 18 years, treated opioids...
Abstract Eosinophils like many myeloid innate immune cells can provide cytokines and chemokines for the activation of other upon TLR stimulation. When ‐stimulated eosinophils were inoculated i.p. into wild‐type mice, NK rapidly recruited exhibited antitumour cytotoxicity. However, when mice depleted CD 11c + used, a marked decrease in number was observed. We postulated that CpG or LPS from injected could be transferred to host cells, which turn recruit cells. by inoculating deficient 4 9...
Objective: The severity of breakthrough cancer pain (BTcP) impacts patients' quality life, increases the risk anxiety and depression, lowers functional capacities, may lead to poor compliance with treatments. aim current study was assess, in a real-life setting, patient satisfaction fentanyl-pectin-nasal-spray (FPNS) for BTcP management head neck (H&N) patients treated by radiotherapy. Materials Methods: This non-interventional, prospective conducted 92 adult H&N-cancer undergoing...
Abstract Purpose Naloxegol, an oral once-daily peripherally acting mu-opioid receptor antagonist, is indicated for the treatment of opioid-induced constipation (OIC) with inadequate response to laxative(s), in cancer and non-cancer patients. This study mainly aimed assess real-life conditions efficacy safety naloxegol pain patients, evolution their quality life. Methods A non-interventional, 4-week follow-up was conducted 24 French oncology centers between 2018 2019. Eligible patients were...
<h3>Introduction</h3> The instant developmental switch of nutritional and oxygen supply from the umbilical cord to lungs intestinal canal are necessary dramatic changes for offspring in order adapt life outside uterus. This period is also characterised by exposure colonisation live bacteria, an assumed important step towards physiological programming newborn. perinatal associated with establishment a functional blood-brain barrier (BBB), essential brain development protection adverse...