A5057452087- Mycobacterium research and diagnosis
- Infective Endocarditis Diagnosis and Management
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Cytomegalovirus and herpesvirus research
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Biosensors and Analytical Detection
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Streptococcal Infections and Treatments
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Antifungal resistance and susceptibility
- vaccines and immunoinformatics approaches
Antwerp University Hospital
2015-2025
University of Antwerp
2008-2024
Universitair Ziekenhuis Leuven
2008
Biology of Infection
2008
University HealthSystem Consortium
2008
Université de Lyon
2008
Hospices Civils de Lyon
2008
Ministère de la Santé et de l'Hygiène Publique
2000
Large-scale serosurveillance of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) will only be possible if serological tests are sufficiently reliable, rapid and affordable. Many assays either labour-intensive require specialised facilities (e.g. virus neutralization assays), or expensive with suboptimal specificity commercial ELISAs RDTs). Bead-based offer a cost-effective alternative allow for multiplexing to test antibodies against multiple antigens other pathogens. Here,...
Cardiovascular complications, including myocarditis, are observed in coronavirus disease 2019 (COVID-19). Major cardiac involvement is a potentially lethal feature severe cases. We sought to describe the underlying pathophysiological mechanism COVID-19 cardiogenic shock.We report on 48-year-old male patient with shock; despite extracorporeal life support, dialysis, and massive pharmacological this rescue therapy was not successful. Severe acute respiratory syndrome 2 RNA detected at autopsy...
The WHO Access, Watch and Reserve (AWaRe) classification has been developed to support countries hospitals in promoting rational use of antibiotics while improving access these essential medicines. We aimed describe patterns worldwide antibiotic according the AWaRe adult inpatient population.The Global Point Prevalence Survey on Antimicrobial Consumption Resistance (Global-PPS) collects hospital data using a standardized PPS methodology. Global-PPS 2015, 2017 2018 data, collected by 664 69...
The level of protection against SARS-CoV-2 breakthrough infections conferred by the presence anti-S1 antibodies (IgGs) in cancer patients is still understudied. This work examines existence an immunoglobulin G (IgG) -based correlate (CoP) established prospectively collected observational data about with different variants a large cohort study vaccinated patients. 760 were longitudinally followed-up, starting before first vaccination until six months after second booster. Anti-S1 IgGs...
This study was conducted to assess the variation in prescription practices for systemic antimicrobial agents used prophylaxis among pediatric patients hospitalized 41 countries worldwide.Using standardized Antibiotic Resistance and Prescribing European Children Point Prevalence Survey protocol, a cross-sectional point-prevalence survey at 226 hospitals from October 1 November 30, 2012.Overall, 17693 were surveyed 36.7% of them received antibiotics (n = 6499). Of 6818 inpatient children, 2242...
Abstract Background It is currently unclear whether SARS-CoV-2 re-infection will remain a rare event, only occurring in individuals who fail to mount an effective immune response, or it occur more frequently when humoral immunity wanes following primary infection. Methods A case of was observed Belgian nosocomial outbreak involving 3 patients and 2 health care workers. To distinguish from persistent infection detect potential transmission clusters, whole genome sequencing performed on...
There is currently no consensus on optimal duration of antibiotic treatment in febrile neutropenia. We report the clinical impact implementation de-escalation and discontinuation strategies based Fourth European Conference Infections Leukaemia (ECIL-4) recommendations high-risk hematological patients.We studied 446 admissions after introduction an ECIL-4-based protocol (hereafter "ECIL-4 group") comparison to a historic cohort 512 admissions. Primary endpoints were incidence infectious...
Abstract Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized confer protection against herpes zoster. We longitudinally sampled 36 adults over course of one year after re-exposure chickenpox. The resulting 183 samples and those 14 controls were assessed for VZV-specific T-cell antibody titres. percentages CD4+ IL-2-producing T-cells increased re-exposed grandparents compared control participants up 9 months...
Antigen recognition through the T cell receptor (TCR) αβ heterodimer is one of primary determinants adaptive immune response. Vaccines activate naïve cells with high specificity to expand and differentiate into memory cells. However, antigen-specific CD4 exist in unexposed antigen-naïve hosts. In this study, we use high-throughput sequencing TCRβ repertoire machine learning show that individuals preexisting vaccine-reactive clonotypes elicited earlier higher antibody titers mounted a more...
The varicella-zoster virus (VZV) infects >95% of the population. VZV reactivation causes herpes zoster (HZ), known as shingles, primarily affecting elderly and individuals who are immunocompromised. However, HZ can occur in otherwise healthy individuals. We analyzed immune signature risk profile patients with using a genome-wide association study across different UK Biobank cohorts. Additionally, we conducted one largest human leukocyte antigen studies to date, coupled transcriptomic...
ABSTRACT Reexposure to viruses is assumed strengthen humoral and cellular immunity via the secondary immune response. We studied effects of frequent exposure viral infectious challenges on immunity. Furthermore, we assessed whether repetitive exposures varicella-zoster virus (VZV) elicited persistently high responses. Blood samples from 11 pediatricians matched controls were at 3 time points 1 point, respectively. Besides assessment general by means measuring T-cell subset percentages,...
Objectives: To determine the role of perinatally acquired Candida colonization to invasive infection (candidemia) and assess risk factors associated with candidemia in neonatal intensive care unit patients. Design: Retrospective case-control study. Setting: Neonatal a teaching hospital. Patients: A total 39 3219 (1.2%) who were positive for at birth compared 117 noncolonized controls. Interventions: Routine surveillance cultures skin meconium performed admission. All neonates during 10-yr...
Infections remain a leading cause of morbidity and mortality in patients with reduced immunity caused by haematological disease chemotherapy-induced neutropenia. We evaluated the clinical microbiological impact discontinuing fluoroquinolone prophylaxis these patients.We analysed 154 admissions three sequential periods 8 months: long-standing use, discontinuation reintroduction prophylaxis. Clinical endpoints were occurrence febrile neutropenia, bacteraemia, severe sepsis, septic shock,...
Point prevalence surveys (PPS) provide valuable data on patterns of hospital antimicrobial administration. To identify quality improvement indicators, we evaluated prescribing in children and neonates admitted to three referral centers Sanandaj, western Iran compared these with South-East Asian European paediatric benchmark data. The standardized Global-PPS was performed assess use Asia, including Sanandaj hospitals 2019. Out 4118, 2915 443 patients enrolled Asian, hospitals, 2342 (56.9%),...
The role of T cell receptor (TCR) diversity in infectious disease susceptibility is not well understood. We use a systems immunology approach on three cohorts herpes zoster (HZ) patients and controls to investigate whether TCR against varicella-zoster virus (VZV) influences the risk HZ. show that CD4
Our objective was to develop and test standardized methods for collection statistical analysis of longitudinal data on hospital antibacterial use from different countries. We collected monthly supply antibiotics pharmacies in one each 18 European applied a method classify drugs, measure defined daily doses compare the effect using occupied bed-days (OBDs) or admissions as denominators analysis. Antibiotic increased 14 (78%) hospitals decreased 4 hospitals. For 16 (89%) hospitals, adjustment...
The use of saliva for the detection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sparks debate due to presumed lower sensitivity and lack standardization. Our aim was evaluate performance characteristics (i) collected by ORAcollectTM device as a matrix SARS-CoV-2 reverse-transcriptase polymerase chain reaction (RT-PCR), (ii) rapid antigen tests (AgRDT). From 342 ambulatory individuals, both nasopharyngeal swab sample via were obtained RT-PCR test. Furthermore, 54 123...
Linezolid resistant opportunistic human pathogens Enterococcus faecalis and faecium are an emerging health threat as limited therapeutic options remain. The aim was to investigate the epidemiology, resistance mechanisms genetic diversity of Belgian linezolid enterococci (LRE) isolated between 2013 2021 received at National Reference Centre (NRC) for Enterococci. susceptibility testing performed upon request on 2458 submitted Enterococci strains. Whole genome sequencing all LRE Seventy-eight...