A5077325007- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Congenital Heart Disease Studies
- Cardiovascular Conditions and Treatments
- Neuroscience of respiration and sleep
- Fetal and Pediatric Neurological Disorders
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Bacterial Infections and Vaccines
- Optical Imaging and Spectroscopy Techniques
- Child and Adolescent Health
- Respiratory viral infections research
- Non-Invasive Vital Sign Monitoring
- Pneumonia and Respiratory Infections
- Traumatic Brain Injury and Neurovascular Disturbances
- Ultrasound in Clinical Applications
- Cardiac Arrhythmias and Treatments
- Cytomegalovirus and herpesvirus research
- Atomic and Subatomic Physics Research
- Aortic Disease and Treatment Approaches
- Neonatal Health and Biochemistry
- Mechanical Circulatory Support Devices
- Infectious Encephalopathies and Encephalitis
- Pharmaceutical studies and practices
- Metabolism and Genetic Disorders
Hospital Universitario Quirónsalud Madrid
2008-2024
Hospital Universitario La Paz
2010-2024
Manhiça Health Research Centre
2024
Instituto de Tecnologías Físicas y de la Información “Leonardo Torres Quevedo”
2024
Barcelona Institute for Global Health
2024
Hospital Sant Joan de Déu Barcelona
2024
Fundación Medina
2024
Universidad Europea
2009-2023
Hospital La Paz Institute for Health Research
2015-2022
University of Bergen
2021
Background. Maintaining adequate organ blood flow is the target of vasopressor treatment, but impact these measures on cerebral perfusion has not yet been evaluated systematically in a randomized, blinded, clinical trial. Objectives. To explore effects brain hemodynamics 2 different inotropic agents used to treat systemic hypotension among low birth weight (LBW) infants. Design and Methods. Newborns <1501 g or <32 weeks' gestational age, with mean pressure (MBP) lower than age...
Abstract Some clusters of children with a multisystem inflammatory syndrome (MIS-C) associated severe acute respiratory coronavirus 2 (SARS-CoV-2) infection have been reported. We describe the epidemiological and clinical features MIS-C in Spain. is potentially condition that presents recent SARS-CoV-2 infection.
Objectives. To investigate if the concentration of interleukin-6 (IL-6) in cerebrospinal fluid (CSF) is affected by perinatal asphyxia, and to examine relation IL-6 levels CSF severity hypoxic-ischemic encephalopathy (HIE), brain damage, neurological outcome. Methods. Asphyxiated term neonates were included. Cerebrospinal was measured a sensitive enzyme-linked immunosorbent assay. Results. Twenty studied: 3 had no HIE, 5 stage 1, 6 2, 3. (8 90 hours life) higher with HIE (range, 65 2250...
Early postnatal adaptation to transitional circulation in low birth weight infants frequently is associated with blood pressure and decreased flow organs. Catecholamines have been used widely as treatment, despite remarkably little empirical evidence on the effects of vasopressor/inotropic support clinically important outcomes sick newborn infants.To explore effectiveness low/moderate-dose dopamine epinephrine treatment early systemic hypotension infants, evaluate frequency adverse drug...
The duration and severity of systemic hypotension have been related with altered neurodevelopment. Cerebral circulation is pressure-passive in low birth weight infants early who receive cardiovascular support. treatment controversial, because it has associated short-term long-term morbidity retrospective studies. However, there no prospective information on support for morbidity.Our goal this study was to evaluate the effect neurodevelopment resulting from use vasopressors/inotropes...
Children represent a minority of total COVID-19 cases, but studies have reported severe disease and death in pediatric patients. Remdesivir (RDV) has recently demonstrated promising results adults with COVID-19, few data been to date children.A nationwide multicenter observational study was conducted on children confirmed SARS-CoV-2 receiving compassionate treatment RDV Spain. Eight patients were included the study, four infants older [median age 5 years old; IQR 4 months-11.6 old]. Half...
Objective To evaluate the association between neuroimaging and outcome in infants with congenital cytomegalovirus (cCMV), focusing on qualitative MRI quantitative diffusion-weighted imaging of white matter abnormalities (WMAs). Methods Multicentre retrospective cohort study 160 cCMV (103 symptomatic). A four-grade scoring system was applied to cranial ultrasonography acquired at ≤3 months. WMAs were categorised as multifocal or diffuse. Temporal-pole (TPWMAs) consisted swollen cystic...
In children with congenital heart disease and/or chronic lung entering their second respiratory syncytial virus (RSV) season, 200 mg nirsevimab had a similar safety profile to that of palivizumab and resulted in serum exposures associated efficacy healthy infants, supporting this population at risk severe RSV disease.
We questioned whether neuron-specific enolase (NSE) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) the first 72 hours of life are correlated with neurologic condition asphyxiated full-term infants neonatal period at 1 year age.Sixty-nine were studied serial examination, cranial ultrasonography, follow-up. CSF samples obtained by lumbar puncture 12 life. NSE was measured enzyme immunoassay, MBP radioimmunoassay.Twenty had no encephalopathy 49 exhibited different...
Background. Mismatch between circulating influenza B viruses (Yamagata and Victoria lineages) vaccine strains occurs frequently.
<b><i>Background:</i></b> Congenital cytomegalovirus (cCMV) can cause brain inflammation/destruction and teratogenic effects. The only validated neuroimaging prognostic categorization for symptomatic cCMV available is based on destructive lesions seen computed tomography (CT). <b><i>Objective:</i></b> aim of this study was to establish the predictive ability a comprehensive neonatal scale in cCMV. <b><i>Methods:</i></b>...
<b><i>Background and Objectives:</i></b> Therapeutic interventions to improve the efficacy of whole-body cooling for hypoxic-ischemic encephalopathy (HIE) are desirable. Topiramate has been effective in reducing brain damage experimental studies. However, clinical setting information is limited a small number feasibility trials. We launched randomized controlled double-blinded topiramate/placebo multicenter trial with primary objective being reduce antiepileptic...
Hypothesis. Laying supine with the head in midline position improves cerebral venous return by preventing functional occlusion of vessels neck. Objectives. To assess changes blood volume (ΔCBV) and flow (CBF) ventilated patients using a noninvasive method. The influence type ventilation birth weight was evaluated. Methods. Thirteen conventionally 8 high-frequency oscillatory infants, mean gestational ages weights 31 ± 5 weeks (24–38) 1575 803 g (560–3000), respectively, were studied 5.8 7.8...