A5083472606- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Asthma and respiratory diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Infectious Diseases and Tuberculosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Child and Adolescent Health
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Pediatric health and respiratory diseases
- Air Quality and Health Impacts
- Diagnosis and treatment of tuberculosis
- Respiratory and Cough-Related Research
- Child Nutrition and Water Access
- Neonatal and fetal brain pathology
- Epigenetics and DNA Methylation
- Inhalation and Respiratory Drug Delivery
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Prenatal Substance Exposure Effects
University of Cape Town
2016-2025
Red Cross War Memorial Children's Hospital
2016-2025
South African Medical Research Council
2016-2025
Institute for Health Metrics and Evaluation
2020-2024
University of Washington
2020-2024
Institut Hospitalier Franco Britannique
2021-2024
University of California, Los Angeles
2024
Wellcome Centre for Human Neuroimaging
2024
King's College London
2024
Neuroscience Institute
2024
Asthma is a serious health problem throughout the world. During past two decades, many scientific advances have improved our understanding of asthma and ability to manage control it effectively. However, recommendations for care need be adapted local conditions, resources services. Since was formed in 1993, Global Initiative Asthma, network individuals, organisations public officials, has played leading role disseminating information about patients with based on process continuous review...
Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)–associated lower tract illness in newborns and infants is uncertain. Download a PDF Research Summary. In this phase 3, double-blind trial conducted 18 countries, we randomly assigned, 1:1 ratio, pregnant women at 24 through 36 weeks' gestation to receive single intramuscular injection 120 μg bivalent RSV prefusion F protein–based (RSVpreF) vaccine or placebo. The two primary efficacy end points...
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection and hospitalization in infants. Nirsevimab monoclonal antibody to the RSV fusion protein that has an extended half-life. The efficacy safety nirsevimab healthy late-preterm term infants are uncertain.
Respiratory epithelial cells play a crucial role in the inflammatory response during Pseudomonas aeruginosa infection lungs of patients with cystic fibrosis. In this study, we determined whether binding specific gene products (pilin, flagellin) to their receptors on respiratory would result production neutrophil chemoattractant IL-8. Piliated wild-type organisms, purified pili, or antibody pilin receptor (asialoGM1) evoked significant IL-8 by immortalized airway cells, whereas nonpiliated...
Abstract Asthma is the most common chronic lower respiratory disease in childhood throughout world. Several guidelines and/or consensus documents are available to support medical decisions on pediatric asthma. Although there no doubt that use of systematic approaches for management can considerably improve outcomes, dissemination and implementation these still major challenges. Consequently, I nternational C ollaboration Asthma, Allergy Immunology (i CAALL ), recently formed by EAACI , AAAAI...
Respiratory syncytial virus (RSV) is the dominant cause of severe lower respiratory tract infection in infants, with most cases concentrated among younger infants.
WHO recommends that Xpert MTB/RIF replaces smear microscopy for initial diagnosis of suspected HIV-associated tuberculosis or multidrug-resistant pulmonary tuberculosis, but no data exist its use in children. We aimed to assess the accuracy test children an area with high and HIV prevalences.
Abstract Asthma is the most common chronic disease of childhood and leading cause morbidity from as measured by school absences, emergency department visits, hospitalions 1 . During past two decades, many scientific advances have improved our understanding asthma ability to manage control it effectively. However, in children 5 years younger, clinical symptoms are variable non‐specific. Furthermore, neither airflow limitation nor airway inflammation, main pathologic hallmarks condition, can...
BackgroundAsthma is the most common chronic disease in children globally. The Global Asthma Network (GAN) Phase I study aimed to determine if worldwide burden of asthma symptoms changing.MethodsThis updated cross-sectional used same methods as International and Allergies Childhood (ISAAC) III. were assessed from centres that completed GAN ISAAC (1993–95), III (2001–03), or both. We included individuals two age groups (children aged 6–7 years adolescents 13–14 years) who self-completed...
Consensus case definitions for childhood tuberculosis have been proposed by an international expert panel, aiming to standardize the reporting of cases in research focusing on diagnosis intrathoracic children. These are intended diagnostic evaluation studies symptomatic children with clinical suspicion tuberculosis, and were not predefine inclusion criteria into such studies. Feedback from researchers suggested that further clarification was required these could be improved. Particular...