A5061554405- Respiratory viral infections research
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- Child and Adolescent Health
- Breastfeeding Practices and Influences
- Cystic Fibrosis Research Advances
- Long-Term Effects of COVID-19
- Food Allergy and Anaphylaxis Research
- Transplantation: Methods and Outcomes
- IL-33, ST2, and ILC Pathways
- Air Quality and Health Impacts
- Infant Development and Preterm Care
- Pneumocystis jirovecii pneumonia detection and treatment
Pontifícia Universidade Católica do Rio Grande do Sul
2016-2025
Hospital Moinhos de Vento
2021-2025
Maastricht University
2024
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2023
Hospital São Lucas da PUCRS
2019-2022
Pontifícia Universidade Católica de São Paulo
2007-2021
Global Virus Network
2018
Pension Fund for Care and Well-Being
2018
Infant Foundation
2014-2016
Colorado School of Public Health
2016
Whether vaccination during pregnancy could reduce the burden of respiratory syncytial virus (RSV)–associated lower tract illness in newborns and infants is uncertain. Download a PDF Research Summary. In this phase 3, double-blind trial conducted 18 countries, we randomly assigned, 1:1 ratio, pregnant women at 24 through 36 weeks' gestation to receive single intramuscular injection 120 μg bivalent RSV prefusion F protein–based (RSVpreF) vaccine or placebo. The two primary efficacy end points...
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota production acetate. Oral administration acetate mediated interferon-β (IFN-β) response by increasing expression interferon-stimulated genes the lung. These effects were associated with reduction viral load pulmonary inflammation RSV-infected mice. Type...
Atopic sensitization has long been known to be related asthma in children, but its role determining prevalence remains elucidated further.To investigate the of atopic large international variation childhood asthma.Cross-sectional studies random samples 8- 12-year-old children (n = 1,000 per center) were performed according standardized methodology Phase Two International Study Asthma and Allergy Childhood (ISAAC). Thirty study centers 22 countries worldwide participated reflect a wide range...
Respiratory syncytial virus (RSV) and influenza are prevalent seasonal community viruses. Although not completely understood, SARS-CoV-2 may have the same means of transmission. Preventive social measures aimed at preventing spread could impact transmission other respiratory viruses as well. The aim this study is to report detection RSV during period distancing due COVID-19 pandemic in a heavily affected community.Prospective with pediatric adult populations seeking care for COVID-19-like...
OBJECTIVE: To evaluate descriptive efficacy data, exploratory immunogenicity and safety follow-up through study completion from the global, phase 3 MATISSE (Maternal Immunization Study for Safety Efficacy) maternal vaccination trial of bivalent respiratory syncytial virus (RSV) prefusion F protein vaccine (RSVpreF). METHODS: was a 3, randomized, double-blinded, placebo-controlled trial. Healthy pregnant participants aged 49 years or younger at 24–36 weeks gestation were randomized (1:1) to...
BACKGROUND: There is increasing evidence that wheezing during childhood may be a heterogeneous condition, and different forms of associated with risk factors prognosis. The aim this study was to determine if measures airway lability atopy could identify distinct phenotypes childhood. METHOD: In cohort children followed from birth peak flow variability (n = 600) evaluated methacholine challenge responsiveness 397) measured at age 11 in relation before the three, six years total serum IgE skin...
Compelling evidence suggests a causal relation between exposure to parental cigarette smoking and respiratory symptoms during childhood. Still, the roles of prenatal versus postnatal need clarification. In this study, authors assessed effects passive on in cohort over 1, 000 children born 1980–1984. The were enrolled Tucson Children's Respiratory Study Tucson, Arizona, followed from birth age 11 years. population was generally middle class consisted two main ethnic groups, non-Hispanic...
Acute viral bronchiolitis by Respiratory Syncytial Virus (RSV) is the most common respiratory illness in children first year of life. RSV generates large numbers hospitalizations and an important burden to health systems. Neutrophils their products are present airways RSV-infected patients who developed increased lung disease. Neutrophil Extracellular Traps (NETs) formed release granular nuclear contents neutrophils extracellular space response different stimuli recent studies have proposed...
Abstract Objective To establish reference values for the 6‐min walk test in healthy children and adolescents aged 6–12 years. Methods This cross‐sectional, prospective study selected years, at three elementary schools Porto Alegre. The anthropometric data of all individuals were evaluated two tests performed. Based on this, a equation was generated, reproducibility evaluated. Results One hundred eighty‐eight (92 boys) performed test. Pearson correlation showed that age (r = 0.51), height...
SummaryExposures to environmental pollutants during windows of developmental vulnerability in early life can cause disease and death infancy childhood as well chronic, non-communicable diseases that may manifest at any point across the span. Patterns pollution pollution-related change countries move through economic development. Environmental is now recognized a major morbidity mortality low- middle-income (LMICs). According World Health Organization, responsible for 8.9 million deaths...