A5065059165- Ion Channels and Receptors
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Mesenchymal stem cell research
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Ion channel regulation and function
- Virus-based gene therapy research
- interferon and immune responses
- Animal Genetics and Reproduction
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry Medicinal Plant Applications
- Occupational Health and Burnout
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Growth and nutrition in plants
- Glycosylation and Glycoproteins Research
- Pain Mechanisms and Treatments
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
- Cynara cardunculus studies
- Heavy Metals in Plants
- Aquaculture Nutrition and Growth
Centro de Pesquisas Oncológicas
2025
Universidade Federal de Santa Catarina
2019-2024
Universidade Federal de Minas Gerais
2020
Universidade Federal de São Paulo
2015-2016
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota production acetate. Oral administration acetate mediated interferon-β (IFN-β) response by increasing expression interferon-stimulated genes the lung. These effects were associated with reduction viral load pulmonary inflammation RSV-infected mice. Type...
The establishment of a virus infection is the result pathogen's ability to replicate in hostile environment generated by host's immune system. Here, we found that ISG15 restricts Dengue and Zika viruses' replication through stabilization its binding partner USP18. expression was necessary control DV driven both autocrine paracrine type one interferon (IFN-I) signaling. Moreover, USP18 competes with NS5-mediated STAT2 degradation, major mechanism for flavivirus infection. Strikingly,...
Glioblastoma (GBM) is an infiltrative tumor that difficult to eradicate. Treating GBM with mesenchymal stem cells (MSCs) have been modified the HSV-Tk suicide gene has brought significant advances mainly because MSCs are chemoattracted and kill via a bystander effect. To use this strategy, abundantly present adipose-tissue-derived (AT-MSCs) were evaluated for treatment of in mice. AT-MSCs prepared using mechanical protocol avoid contamination animal protein transduced lentiviral vector. The...
Brucella abortus is a facultative intracellular bacterium that causes brucellosis, prevalent zoonosis leads to abortion and infertility in cattle, undulant fever, debilitating arthritis, endocarditis, meningitis humans. Signaling pathways triggered by B. involves stimulator of IFN genes (STING), which production type I IFNs. In this study, we evaluated the pathway linking unfolded protein response (UPR) endoplasmic reticulum-resident transmembrane molecule STING, during infection. We...
Orally available antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are necessary because of the continuous circulation new variants that challenge immunized individuals. Because COVID-19 is a virus-triggered immune and inflammatory dysfunction, molecules endowed with both antiviral anti-inflammatory activity highly desirable. We identified here kinetin (MB-905) inhibits in vitro replication SARS-CoV-2 human hepatic pulmonary cell lines. On infected monocytes,...
Obesity is a global epidemic often associated with serious medical complications such as diabetes, hypertension and metabolic dysfunction-associated steatohepatitis. Considering the multifactorial nature of these diseases, medicinal plants could be valuable therapeutic strategy their phytoconstituents interact multiple relevant biological targets. In this context, Ilex paraguariensis emerges potential alternative to treat obesity diseases since several studies have demonstrated its...
Abstract Background and Purpose Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen‐derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regulate the neutrophil dysregulation observed Experimental Approach The effects of inhibitors on lipopolysaccharide (LPS)‐stimulated neutrophils from healthy donors or COVID‐19 patients were determined by evaluating shedding surface sialic acids, cell...
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibitors constrain host activity, release, ROS production, and NETs released by microbial-activated human neutrophils. In vivo, treatment with Oseltamivir results infection control survival peritonitis pneumonia models sepsis. Single-cell RNA...
Phα1β a spider peptide, purified from the venom of Phoneutria nigriventer inhibits high voltage calcium channels and is antagonist TRPA1 receptor two important pain transduction path-ways. In last 15 years, we have showed, in preclinical tests with native recombi-nant rodent models potential to become new analgesic drug. Evaluation drug on human ERG channel requirement regulatory agencies. For hERG inhibition assay it was used commercial kit FLIPR® Potassium Assay. It tested effect as...
SUMMARY The establishment of a virus infection is the result pathogen’s ability to replicate in hostile environment generated by host’s immune system. Here, we found that ISG15 restricts Dengue and Zika viruses’ replication through stabilisation its binding partner USP18. expression was necessary control DV driven both autocrine paracrine type one interferon (IFN-I) signalling. Moreover, USP18 competes with NS5-mediated STAT2 degradation, major mechanism for flavivirus infection. Strikingly,...
Glioblastoma (GBM) is the most common and lethal primary intracranial tumor. Because GBM highly invasive diffusely infiltrates brain, a complete resection of tumor unfeasible. The gene encoding thymidine kinase from herpes simplex virus-1 (HSV-Tk) commonly used suicide in preclinical clinical trials against GBM. Treating with mesenchymal stem cells (MSCs) that have been modified HSV-Tk has brought significant advances mainly because MSCs are chemoattracted to kill via bystander effect....