A5007687148- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Tryptophan and brain disorders
- Laser Applications in Dentistry and Medicine
- Treatment of Major Depression
- Pain Management and Treatment
- Healthcare and Venom Research
- Ion channel regulation and function
- Stress Responses and Cortisol
- Botulinum Toxin and Related Neurological Disorders
- Multiple Sclerosis Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Infrared Thermography in Medicine
- Herbal Medicine Research Studies
- Pediatric health and respiratory diseases
- Ultrasound and Hyperthermia Applications
- Orthoptera Research and Taxonomy
- Musculoskeletal pain and rehabilitation
- Atherosclerosis and Cardiovascular Diseases
- Effects of Radiation Exposure
- Axon Guidance and Neuronal Signaling
- Botanical Research and Chemistry
- Pharmacological Receptor Mechanisms and Effects
- Peripheral Neuropathies and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
Universidade Federal de Santa Catarina
2017-2023
Spirulina platensis is a "super-food" and has attracted researchers' attention due to its anti-inflammatory, antioxidant, analgesic properties. Herein, we investigated the antinociceptive effects of in different rodent behavior models inflammatory pain. Male Swiss mice were treated with (3-300 mg/kg, p.o.), indomethacin (10 or vehicle (0.9% NaCl 10 mL/kg). Behavioral tests performed administration acetic acid (0.6%, i.p.), formalin 2.7% (formaldehyde 1%, i.pl.), menthol (1.2 µmol/paw,...
Depression has a multifactorial etiology that arises from environmental, psychological, genetic, and biological factors. Environmental stress genetic factors acting through immunological endocrine responses generate structural functional changes in the brain, inducing neurogenesis neurotransmission dysfunction. Terpineol, monoterpenoid alcohol, shown immunomodulatory neuroprotective effects, but there is no report about its antidepressant potential. Herein, we used single lipopolysaccharide...
Citral ((2E)-3,7-dimethylocta-2,6-dienal), a bioactive component of lemongrass, inhibits oxidant activity, nuclear factor kappa B (NF-κB) activation, and cyclooxygenase-2 (COX-2) expression, even as it activates peroxisome proliferator-activated receptor (PPAR)-α γ. Additionally, citral produces long-lasting inhibition transient potential (TRP) channels that are found in sensory neurons, such TRPV1-3 TRPM8, while transiently blocks TRPV4 TRPA1. Here, the effect experimental models acute...
Rosmarinic acid (RA), an ester of caffeic and 3, 4‐dihydroxyphenyllactic acid, has anti‐inflammatory neuroprotective activities. Herein, this study investigated in silico the drug‐likeness potential molecular targets to RA. Moreover, it tested antidepressant‐like RA lipopolysaccharide (LPS)‐induced depression model. (MW = 360.31 g/mol) meets criteria both Lipinski's rule five Ghose filter. It also attends relevant pharmacokinetic parameters. Target prediction analysis identified RA's...
Simvastatin is a lipid-lowering agent that blocks the production of cholesterol through inhibition 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. In addition, recent evidence has suggested its anti-inflammatory and antinociceptive actions during inflammatory pain disorders. Herein, we investigated effects simvastatin in an animal model complex regional syndrome-type I, underlying mechanisms. Chronic post-ischemia (CPIP) was induced by ischemia reperfusion (IR) injury left hind...
Summary Analysing nematode behaviour helps estimate biomechanical parameters for applications like cellular biology, pharmacology and cognitive neuroscience. Portable holographic platforms offer cost-effective, high-resolution, high-frame-rate, wide-field imaging compared to conventional microscopy. Holographic methods can reconstruct original shapes using numerical diffraction, although this is computationally expensive. However, video holography remains challenging due the fast motion...
The present study investigated the effects of pulsed and continuous ultrasound (USP USC) in edema hyperalgesia after chronic inflammatory process induced by Complete Freund's Adjuvant-CFA analyzing relationship application frequency ultrasound, pro- anti-inflammatory cytokine production.Forty-five animals were divided into 9 groups; all from groups 2 to subjected a persistent inflammation model CFA mice. We report underlying action mechanisms USP USC which irradiated two, three or five times...
Abstract The CTK 01512-2 toxin is a recombinant peptide of the Phα1β version derived from venom Phoneutria nigriventer spider. It an N-type voltage-gated calcium channel (VGCC) blocker showing prolonged effect on prevention and reduction nociception. Herein, was tested in two models persistent pain, chronic post-ischemia pain (CPIP) peripheral neuropathy induced by paclitaxel, to evaluate its intrathecal, systemic, intracerebroventricular effects mechanical hypersensitivity thermal...
Abstract The dopaminergic system plays an essential role in maintaining homeostasis between the central nervous (CNS) and immune system. Previous studies have associated imbalances with pathogenesis of multiple sclerosis (MS). Herein, we investigate protein levels receptors (D1R D2R) different phases experimental autoimmune encephalomyelitis (EAE) model. We also examined if treatment pramipexole (PPX) – a dopamine D2/D3 receptor-preferring agonist would be able to prevent EAE-induced motor...