Piotr Kuna
A5001308400- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Drug-Induced Adverse Reactions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mast cells and histamine
- Nutrition and Health Studies
- Immune Cell Function and Interaction
- Delphi Technique in Research
- Effects of Radiation Exposure
- Health and Medical Studies
- Inflammatory mediators and NSAID effects
- Neonatal Respiratory Health Research
- Contact Dermatitis and Allergies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Esophagitis
- Nasal Surgery and Airway Studies
- Olfactory and Sensory Function Studies
Medical University of Lodz
2016-2025
Charité - Universitätsmedizin Berlin
2019-2024
University of Łódź
2024
Royal Brompton Hospital
2023
Humanitas University
2022
Humboldt-Universität zu Berlin
2019-2021
Sanofi (France)
2021
Takeda (Italy)
2021
Novartis (Ireland)
2021
ENT and Allergy
2021
Many patients with severe asthma rely on oral glucocorticoids to manage their disease. We investigated whether benralizumab, a monoclonal antibody directed against the alpha subunit of interleukin-5 receptor that significantly reduces incidence exacerbations, was also effective as an glucocorticoid-sparing therapy in relying associated eosinophilia.In 28-week randomized, controlled trial, we assessed effects benralizumab (at dose 30 mg administered subcutaneously either every 4 weeks or 8...
Abstract Asthma is the most common chronic lower respiratory disease in childhood throughout world. Several guidelines and/or consensus documents are available to support medical decisions on pediatric asthma. Although there no doubt that use of systematic approaches for management can considerably improve outcomes, dissemination and implementation these still major challenges. Consequently, I nternational C ollaboration Asthma, Allergy Immunology (i CAALL ), recently formed by EAACI , AAAAI...
The house dust mite (HDM) sublingual allergen immunotherapy (SLIT) tablet is a potential novel treatment option for HDM allergy-related asthma.To evaluate the efficacy and adverse events of SLIT vs placebo asthma exacerbations during an inhaled corticosteroid (ICS) reduction period.Double-blind, randomized, placebo-controlled trial conducted between August 2011 April 2013 in 109 European sites. included 834 adults with not well controlled by ICS or combination products, rhinitis. Key...
Rationale: There is no consensus on criteria to include in an asthma remission definition real-life. Factors associated with achieving post-biologic-initiation remain poorly understood. Objectives: To quantify the proportion of adults severe multi-domain-defined and identify pre-biologic characteristics which may be used predict it. Methods: This was a longitudinal cohort study using data from 23 countries International Severe Asthma Registry. Four outcome domains were assessed 1-year pre-...
The International Severe Asthma Registry (ISAR) was established in 2017 to advance the understanding of severe asthma and its management, thereby improving patient care worldwide. As first global registry for adults with asthma, ISAR enabled individual registries standardize pool their data, creating a comprehensive, harmonized dataset sufficient statistical power address key research questions knowledge gaps. Today, is largest repository real-world data on curating nearly 35,000 patients...
Leukotriene antagonists block the proinflammatory actions of leukotrienes (LT) and have been introduced as new treatments for asthma. Conventional therapy with glucocorticosteroids does not inhibit biosynthesis leukotrienes. We therefore tested whether addition leukotriene receptor antagonist montelukast was therapeutic benefit in a group aspirin-intolerant patients asthma whom 90% already were treated moderate to high doses glucocorticosteroids. Under double-blind conditions, 80 randomized...
This randomised, double-blind, 6-month study compared budesonide/formoterol for maintenance and relief with salmeterol/fluticasone a fixed dose of budesonide/formoterol, both terbutaline relief. Following 2-week run-in, 3335 symptomatic adults adolescents (mean FEV1 73% predicted, mean inhaled corticosteroid 745 μg/day) received 160/4.5 μg one inhalation bid plus additional inhalations as needed, 25/125 two as-needed or 320/9 terbutaline. Budesonide/formoterol prolonged the time to first...
This article was originally published online on 19 November 2009 Asia Pacific Association of Allergology and Clinical Immunology. Commonwealth Independent States (CIS). European Academy Allergy Immunology (EAACI). Latin American Society Interasma (International Asthmology). Albanian South Africa. Allergy, Asthma College Argentine Australasian Allergy. Bangladesh Belgian Brazilian Immunopathology. British for Bulgarian National Allergology. China Chinese Allergists. Cuban Czech Finnish French...
Chemotaxis of different populations cells and release proinflammatory mediators in response to antigenic stimulation are important processes allergic diseases. These lead the late phase response, a hallmark chronic Recombinant RANTES, member "intercrine/chemokine" family cytokines, has been previously shown be chemotactic for monocytes T memory/helper phenotype. In this manuscript, we show that it is capable inducing histamine from human basophils at concentrations as low 10(-10) M compare...
Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) Histamine by MCAF rapid an initial rate comparable optimal anti-IgE. led within 1 min. 80% the subjects tested were responsive or anti-IgE, while all FMLP. percentage was, however, less than that seen anti-IgE FMLP, but this attributable lesser percent in nonatopic subjects;...