A5029497606- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Food Allergy and Anaphylaxis Research
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Health and Disease Prevention
- Chronic Disease Management Strategies
- Helicobacter pylori-related gastroenterology studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular and exercise physiology
- Pharmaceutical studies and practices
- Antimicrobial Peptides and Activities
- Hematopoietic Stem Cell Transplantation
- Neuroscience of respiration and sleep
University of Calgary
2016-2025
Royal Brompton Hospital
2023
Alberta Health Services
2009-2023
Alberta Health
2023
University of Alberta
2017
University of Toronto
2016
Institute of Infection and Immunity
2008-2014
U.S. Green Building Council
2014
West Virginia University
2013
GlaxoSmithKline (United Kingdom)
2013
Systemic corticosteroids play an integral role in the management of many inflammatory and immunologic conditions, but these agents are also associated with serious risks. Osteoporosis, adrenal suppression, hyperglycemia, dyslipidemia, cardiovascular disease, Cushing's syndrome, psychiatric disturbances immunosuppression among more side effects noted systemic corticosteroid therapy, particularly when used at high doses for prolonged periods. This comprehensive article reviews adverse events...
Thymic stromal lymphopoietin (TSLP) is an epithelial-cell-derived cytokine that may be important in initiating allergic inflammation. AMG 157 a human anti-TSLP monoclonal immunoglobulin G2λ binds TSLP and prevents receptor interaction.In this double-blind, placebo-controlled study, we randomly assigned 31 patients with mild asthma to receive three monthly doses of (700 mg) or placebo intravenously. We conducted allergen challenges on days 42 84 evaluate the effect reducing maximum percentage...
BACKGROUND: In 2010, the Canadian Thoracic Society (CTS) published a Consensus Summary for diagnosis and management of asthma in children six years age older, adults, including an updated Asthma Management Continuum. The CTS Clinical Assembly subsequently began formal clinical practice guideline update process, focusing, this first iteration, on topics controversy and/or gaps previous guidelines. METHODS: Four questions were identified as focus guideline: role noninvasive measurements airway...
Mepolizumab has demonstrated favorable safety and efficacy profiles in placebo-controlled trials of 12 months' duration or less; however, long-term data are lacking.We sought to evaluate the mepolizumab patients with severe eosinophilic asthma (SEA).COLUMBA (Open-label Long Term Extension Safety Study Asthmatic Subjects, NCT01691859) was an open-label extension study SEA previously enrolled DREAM (Dose Ranging Efficacy And With Severe Asthma, NCT01000506). Patients received 100 mg...
PurposePatients with severe eosinophilic asthma often experience recurrent exacerbations despite intensive inhaled corticosteroid therapy. In 2 previous double-blind studies (MENSA [NCT01691521] and SIRIUS [NCT01691508]), treatment intravenous or subcutaneous mepolizumab was associated significantly reduced annualized exacerbation rates oral (OCS) requirements compared placebo. The purpose of this study to assess the long-term safety efficacy in patients asthma.MethodsCOSMOS a 52-week,...
Induced sputum cell counts provide a relatively noninvasive method to evaluate the presence, type, and degree of inflammation in airways lungs. Their interpretation requires knowledge normal values from healthy population. The objective was examine total differential induced sample adults. A 118 nonsmoking adults were studied. None had asthma or airflow obstruction (negative history, FEV1 ⩾ 80% predicted, ratio vital capacity [FEV1/VC] 80%, methacholine PC20 16 mg/ml). Forty-six atopic....
The role of inhaled corticosteroids in the management chronic obstructive pulmonary disease (COPD) remains controversial. purpose this study was to evaluate whether sputum eosinophilia (defined as eosinophils > or = 3%) predicts clinical benefit from corticosteroid treatment patients with smoking-related clinically stable moderate-to-severe COPD. Forty consecutive effort dyspnoea (mean age 67 yrs; 52 pack-yr smoking history; post-bronchodilator forced expiratory volume one second (FEV1) <60%...
BACKGROUND/OBJECTIVE: To integrate new evidence into the Canadian Asthma Management Continuum diagram, encompassing both pediatric and adult asthma. METHODS: The Thoracic Society Committee members, comprised of experts in respirology, allergy immunology, emergency medicine, general pediatrics, family pharmacoepidemiology evidence‐based updated continuum based primarily on 2008 Global Initiative for guidelines, performed a focused review literature pertaining to key aspects asthma diagnosis...
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Abstract Background Preclinical studies suggest that interleukin-9 may be a central mediator in the development and maintenance of airway inflammation asthma. The aim this study was therefore to evaluate effects MEDI-528, an anti-interleukin-9 monoclonal antibody, adults with confirmed uncontrolled moderate-to-severe Methods In prospective double-blind, multicenter, parallel-group study, 329 subjects were randomized (1:1:1:1) subcutaneous placebo or MEDI-528 (30, 100, 300 mg) every 2 weeks...
A humanized monoclonal antibody that targets the membrane IgE B cell receptor was associated with improvements in asthmatic airway responses.
Thymic stromal lymphopoietin (TSLP) is a key upstream regulator driving allergic inflammatory responses. We evaluated the efficacy and safety of ecleralimab, potent inhaled neutralising antibody fragment against human TSLP, using allergen inhalation challenge (AIC) in subjects with mild atopic asthma.This was 12-week, randomised, double-blind, placebo-controlled, parallel-design, multicentre bronchoprovocation study conducted at 10 centres across Canada Germany. Subjects aged 18-60 years...
The mechanisms underlying airway hyperresponsiveness remain unclear, although inflammation and remodeling likely play important roles. We have observed sustained hyperreactivity occurring in mice after chronic allergen exposure persisting beyond resolution of allergen-induced inflammation. aim this study was to delineate involved examine evidence for a causal association between hyperreactivity. Wild-type (WT) interleukin (IL)-4-, IL-5-, IL-13-deficient (-/-) were sensitized studied 4 weeks...