A5022616366- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Atomic and Subatomic Physics Research
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Transplantation: Methods and Outcomes
- Advanced Chemical Sensor Technologies
- Pediatric health and respiratory diseases
- Advanced MRI Techniques and Applications
- IL-33, ST2, and ILC Pathways
- Organ Transplantation Techniques and Outcomes
- Immune Response and Inflammation
- Air Quality and Health Impacts
- Dermatology and Skin Diseases
- Pulmonary Hypertension Research and Treatments
- Contact Dermatitis and Allergies
- Immune Cell Function and Interaction
- Olfactory and Sensory Function Studies
- Neuroscience of respiration and sleep
- Air Quality Monitoring and Forecasting
- Advanced NMR Techniques and Applications
- Eosinophilic Esophagitis
German Center for Lung Research
2016-2025
Medizinische Hochschule Hannover
2016-2025
Fraunhofer Institute for Toxicology and Experimental Medicine
2016-2025
Fraunhofer Society
2003-2015
Universitätsklinikum Gießen und Marburg
2011
University of Mississippi Medical Center
2011
State Street (United States)
2011
Quest University Canada
2011
Respiratory Clinical Trials
2009
Hôpital Orthopédique de la Suisse Romande
2009
Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables exhaled breath condensate (EBC) and other measurements. For EBC for FeNO, official recommendations standardised procedures are more than 10 years old there is none VOCs particles. The aim this document to provide technical standards sample collection analytic approaches highlight future research priorities field. new developments advances technology have been evaluated current...
Critical examination of the quality and validity available allergic rhinitis (AR) literature is necessary to improve understanding appropriately translate this knowledge clinical care AR patient. To evaluate existing literature, international multidisciplinary experts with an interest in have produced International Consensus statement on Allergy Rhinology: Allergic Rhinitis (ICAR:AR).Using previously described methodology, specific topics were developed relating AR. Each topic was assigned a...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound (mIL-6R) or soluble (sIL-6R) and glycoprotein 130 (gp130). In this study, we investigated role IL-6R components in asthma. We observed increased levels sIL-6R airways patients with allergic asthma as compared to those controls. addition, local blockade murine model late-phase after OVA sensitization by gp130–fraction constant led suppression Th2 cells lung. By contrast, mIL-6R induced expansion...
The most prevalent phenotype of asthma is characterized by eosinophil-dominated inflammation that driven a type 2 helper T cell (Th2). Therapeutic targeting GATA3, an important transcription factor the Th2 pathway, may be beneficial. We evaluated safety and efficacy SB010, novel DNA enzyme (DNAzyme) able to cleave inactivate GATA3 messenger RNA (mRNA).
BackgroundAlthough several studies link high levels of IL-6 and soluble receptor (sIL-6R) to asthma severity decreased lung function, the role trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought explore association between epithelial IL-6TS pathway activation molecular clinical phenotypes patients.MethodsAn gene signature obtained from air-liquid interface cultures human bronchial cells stimulated with sIL-6R was used stratify transcriptomic data (Unbiased Biomarkers...
The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound (mIL-6R) or soluble (sIL-6R) and glycoprotein 130 (gp130). In this study, we investigated role IL-6R components in asthma. We observed increased levels sIL-6R airways patients with allergic asthma as compared to those controls. addition, local blockade murine model late-phase after OVA sensitization by gp130–fraction constant led suppression Th2 cells lung. By contrast, mIL-6R induced expansion...
Epidemiologic studies have shown an increased prevalence of allergic asthma in children living a German smelter area (Hettstedt) compared with cohort who live nonindustrialized (Zerbst). However, it is not known whether ambient particles (particulate matter2.5 [PM2.5]) from these areas induce distinct lung inflammation, which might be explanation for this difference. Therefore, 100 μg PM2.5 suspensions, collected simultaneously the two areas, were instilled through bronchoscope into...
Assessment of cardiac output is an important part the management patients with pulmonary hypertension. The accuracy thermodilution technique in low or severe tricuspid regurgitation has been questioned. To address this issue, we simultaneously compared 105 measurements by Fick method and 35 Moreover, evaluated acetylene rebreathing technique, a noninvasive determining output. mean difference +/- 95% limit agreement between was +0.01 1.1 L/min. -0.23 1.14 Neither nor limits both were affected...
Abstract Background The loss of alveolar walls is a hallmark emphysema. As fibroblasts play an important role in the maintenance structure, change fibroblast phenotype could be involved pathogenesis this disease. In previous study we found reduced vitro proliferation rate and number population doublings parenchymal lung from patients with emphysema hypothesized that these findings related to premature cellular aging cells. study, therefore compared senescence markers expression respective...
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with variable and unpredictable course.
Pulmonary surfactant protein D (SP-D) is considered as a candidate biomarker for the functional integrity of lung and disease progression, which can be detected in serum. The origin SP-D serum how concentrations are related to pulmonary under inflammatory conditions still unclear.In cross-sectional study comprising non-smokers (n=10), young--(n=10), elderly smokers (n=20), with COPD (n=20) we simultaneously analysed levels regard function, exercise, repeatability its quaternary structure by...
Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation and bacterial dysbiosis. The relationship between the microbiome bronchial gene expression in COPD poorly understood. We aimed to identify differences from brushings patients healthy individuals investigate whether any distinguishing bacteria are related expression.For this 16S rRNA sequencing host transcriptomic analysis, aged 45-75 years mild-to-moderate either receiving or not inhaled corticosteroids same...
Thymic stromal lymphopoietin (TSLP) is a key upstream regulator driving allergic inflammatory responses. We evaluated the efficacy and safety of ecleralimab, potent inhaled neutralising antibody fragment against human TSLP, using allergen inhalation challenge (AIC) in subjects with mild atopic asthma.This was 12-week, randomised, double-blind, placebo-controlled, parallel-design, multicentre bronchoprovocation study conducted at 10 centres across Canada Germany. Subjects aged 18-60 years...
Allergic asthma is thought to be the result of an inappropriate specific immune response against common environmental antigens. However, studies animal models have also linked innate system, in particular complement factors C3a and C5, murine airway hyperresponsiveness. Because possible role these anaphylatoxins patients with not understood, we tested hypothesis that C5a will increase bronchoalveolar lavage (BAL) fluid after segmental allergen provocation. In a group 15 subjects mild found...
Cytochrome P450 monooxygenases (CYP) play an important role in the defense against inhaled toxicants, and expression of CYP enzymes may differ among various lung cells tissue compartments.
Noninvasive monitoring of airway inflammation is important for diagnosis and treatment intervention lung disease. Mediators interest are often nonvolatile molecules that exhaled as aerosols captured by breath condensation. Because analysis condensate has been troublesome in the past, partly due to poor standardization unknown dilution, we investigated detail influence respiratory variables on particle number size distribution during tidal breathing healthy volunteers.Particle was detected a...
Abstract Background Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in alveoli where inhaled nanoparticles preferentially deposit. We investigated effect of titanium dioxide (TiO 2 ) nanosized particles (NSP) microsized (MSP) on biophysical function after direct particle contact area cycling vitro . In addition, TiO effects ultrastructure were visualized. Methods A natural porcine preparation was incubated with increasing concentrations (50-500 μg/ml)...
There is increasing evidence that breath volatile organic compounds (VOC) have the potential to support diagnosis and management of inflammatory diseases such as COPD. In this study we used a novel sampling device search for COPD related VOCs. We included large number healthy controls patients with mild moderate COPD, recruited subjects at two different sites carefully controlled smoking.