Anoop Chauhan
A5046014607- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Coronary Interventions and Diagnostics
- Pediatric health and respiratory diseases
- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Venous Thromboembolism Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Delphi Technique in Research
- Respiratory viral infections research
- Non-Invasive Vital Sign Monitoring
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Cardiac Valve Diseases and Treatments
- Phonocardiography and Auscultation Techniques
- Mobile Health and mHealth Applications
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Transplantation: Methods and Outcomes
Portsmouth Hospitals NHS Trust
2016-2025
Northern Health
2025
University of Portsmouth
2014-2024
National Health Service
2017-2023
University of Minnesota System
2023
Government of the United Kingdom
2023
Queen Alexandra Hospital
2010-2022
University Hospitals Birmingham NHS Foundation Trust
2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase affinity the ACE2 confer antibody escape. In vitro, we show that, although itself is not an evasion mechanism, it increases infectivity associated with enhanced incorporation cleaved into virions. able partially rescue proteins that have acquired Y453F escape...
Objective To obtain evidence whether the online pulmonary rehabilitation(PR) programme ‘my-PR’ is non-inferior to a conventional face-to-face PR in improving physical performance and symptom scores patients with COPD. Design A two-arm parallel single-blind, randomised controlled trial. Setting The arm carried out rehabilitation their own homes face local facility. Participants 90 diagnosis of chronic obstructive disease (COPD), modified Medical Research Council score 2 or greater referred...
<h3>Importance</h3> For treatment of malignant pleural effusion, nonsteroidal anti-inflammatory drugs (NSAIDs) are avoided because they may reduce pleurodesis efficacy. Smaller chest tubes be less painful than larger tubes, but efficacy in has not been proven. <h3>Objective</h3> To assess the effect tube size and analgesia (NSAIDs vs opiates) on pain clinical related to patients with effusion. <h3>Design, Setting, Participants</h3> A 2×2 factorial phase 3 randomized trial among 320 requiring...
BackgroundAlthough several studies link high levels of IL-6 and soluble receptor (sIL-6R) to asthma severity decreased lung function, the role trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought explore association between epithelial IL-6TS pathway activation molecular clinical phenotypes patients.MethodsAn gene signature obtained from air-liquid interface cultures human bronchial cells stimulated with sIL-6R was used stratify transcriptomic data (Unbiased Biomarkers...
This study was performed to compare the frequency of early complications after single chamber versus dual permanent pacemaker implantation. Early complication defined as one occurring in 6-week period following We prospectively analyzed consecutive implantation from January 1987 June 1993 at our regional center. All were also for relationship operator experience, venous access route, and presence temporary pacing wire time system. A total 2019 new units implanted during this period. 1733...
We examined the feasibility of using induced sputum to evaluate airway inflammatory response natural acute respiratory virus infections. recruited eight asthmatics and nine healthy subjects on Day 4 a cold. Viral infection was confirmed in six (influenza A or B) A, rhinovirus, adenovirus, syncytial virus, coronavirus). In with infection, five had an objective exacerbation asthma during Their showed high median total cell count 19.7 × 106 cells/ml modest neutrophilia (58.5%) levels...
Tumour necrosis factor alpha (TNFalpha) is a cytokine recognised as therapeutic target in chronic inflammatory diseases.A randomised, double blind, placebo controlled parallel group trial reported of etanercept (an IgG1-TNF p75 receptor fusion protein), administered once weekly for 12 weeks 39 patients with severe corticosteroid refractory asthma. Efficacy was measured by change from the pretreatment baseline Asthma Related Quality Life (AQLQ) and Control (ACQ) Questionnaire scores (the...
<h3>Importance</h3> Guidelines recommend against antibiotic use to treat asthma attacks. A study with telithromycin reported benefit, but adverse reactions limit its use. <h3>Objective</h3> To determine whether azithromycin added standard care for attacks in adults results clinical benefit. <h3>Design, Setting, and Participants</h3> The Azithromycin Against Placebo Exacerbations of Asthma (AZALEA) randomized, double-blind, placebo-controlled trial, a United Kingdom–based multicenter...
Abstract Errors in the use of different inhalers were investigated patients naive to devices under investigation a multicentre, single-visit, randomised, open-label, cross-over study. Patients with chronic obstructive pulmonary disease (COPD) or asthma assigned ELLIPTA vs DISKUS (Accuhaler), metered-dose inhaler (MDI) Turbuhaler. COPD also Handihaler Breezhaler. demonstrated after reading patient information leaflet (PIL). A trained investigator assessed critical errors (i.e., those likely...
Multicentre training could reduce biases in medical artificial intelligence (AI); however, ethical, legal, and technical considerations can constrain the ability of hospitals to share data. Federated learning enables institutions participate algorithm development while retaining custody their data but uptake has been limited, possibly as deployment requires specialist software expertise at each site. We previously developed an intelligence-driven screening test for COVID-19 emergency...
Previous publications have highlighted the disparity between research trial populations and those in clinical practice, but it has not been established how this relates to randomised controlled trials (RCTs) of phenotype-targeted biological therapies severe asthma. Detailed characterisation data for 342 asthma patients within Wessex Severe Asthma Cohort (WSAC) was compared against comprehensive eligibility criteria published phase IIB III RCTs evaluating since 2000. 37 20 were identified....
Exacerbations of COPD are one the commonest causes admission and readmission to hospital. The role digital interventions support self-management in improving outcomes is uncertain. We conducted an open, randomised controlled trial a health platform application (app) 41 patients recruited following hospital with acute exacerbation. Subjects were either receive usual care, including written plan (n = 21), or myCOPD app 20) for 90 days. primary efficacy outcome was recovery rate symptoms...
Malignant pleural mesothelioma (MPM) has a high symptom burden and poor survival. Evidence from other cancer types suggests some benefit in health-related quality of life (HRQoL) with early specialist palliative care (SPC) integrated oncological services, but the certainty evidence is low.We performed multicentre, randomised, parallel group controlled trial comparing referral to SPC versus standard across 19 hospital sites UK one large site Western Australia. Participants had newly diagnosed...
OBJECTIVES--To assess the effect of hyperventilation and mental stress on coronary blood flow symptom production in patients with syndrome X. DESIGN--A prospective study. Hyperventilation tests were performed ward repeated cardiac catheter laboratory where velocity was also measured an intracoronary Doppler left anterior descending artery. Oesophageal manometry studies performed. PATIENTS--29 X (typical anginal chest pain, a positive exercise test, normal angiogram). SETTING--A regional...