A5046872821- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Pharmacological Effects and Assays
- Receptor Mechanisms and Signaling
- Inflammatory mediators and NSAID effects
- Eosinophilic Esophagitis
- Heart Failure Treatment and Management
- Pharmaceutical studies and practices
- Cystic Fibrosis Research Advances
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Lung Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Heart Rate Variability and Autonomic Control
- Connective tissue disorders research
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
University of Glasgow
2016-2025
British Columbia Children's Hospital
2025
University of Surrey
2024
University of Dundee
2023
British Heart Foundation
2023
University of Leicester
2023
European Federation of Allergy and Airways Diseases Patients Associations
2023
Chalmers University of Technology
2023
University of Nottingham
2023
University of Edinburgh
2023
Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy applied to the airway wall decrease smooth muscle.To evaluate effectiveness and safety of BT versus sham subjects with severe asthma who remain symptomatic despite treatment high-dose inhaled corticosteroids long-acting beta(2)-agonists.A total 288 adult (Intent-to-Treat [ITT]) randomized or control underwent three bronchoscopy procedures. Primary outcome was difference Asthma Quality Life...
Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined effect bronchial on control moderate or severe persistent asthma.We randomly assigned 112 subjects who had been treated with inhaled corticosteroids long-acting beta2-adrenergic agonists (LABA) in whom asthma was impaired when LABA were withdrawn either group. The primary outcome frequency mild exacerbations, calculated during three scheduled 2-week...
The study was designed to assess the effect of cigarette smoking on therapeutic response oral corticosteroids in chronic stable asthma. We performed a randomized, placebo-controlled, crossover with prednisolone (40 mg daily) or placebo for 2 weeks smokers asthma, ex-smokers and never-smokers All subjects had reversibility FEV1 after nebulized albuterol 15% more mean postbronchodilator FEV1% predicted than 80%. Efficacy assessed using FEV1, daily PEF, an asthma control score. There...
BackgroundUnderstanding the genetic basis of airflow obstruction and smoking behaviour is key to determining pathophysiology chronic obstructive pulmonary disease (COPD). We used UK Biobank data study causes lung health.MethodsWe sampled individuals European ancestry from Biobank, middle extremes forced expiratory volume in 1 s (FEV1) distribution among heavy smokers (mean 35 pack-years) never smokers. developed a custom array for provide optimum genome-wide coverage common low-frequency...
Bronchial thermoplasty (BT) is designed to reduce airway smooth muscle and improve asthma control.This study was conducted determine the safety efficacy of this procedure in subjects with symptomatic, severe asthma.Adults who were symptomatic despite treatment fluticasone or equivalent at more than 750 mug/day, a long-acting beta(2)-agonist, other medications, which could include 30 mg less oral prednisolone/day, randomized BT control group. After treatment, entered 16-week steroid stable...
Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral protein, IFN-β. Exogenous IFN-β restores activity.To compare efficacy and safety inhaled placebo administered after onset cold symptoms prevent or attenuate respiratory viruses.A total 147 on corticosteroids (British Thoracic Society Steps 2-5), a history virus-associated exacerbations, were randomized 14-day treatment (n = 72) 75) within 24...
Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel variants associated with asthma, see whether previously identified for all types of contribute and provide mechanistic insights using expression analyses in patients asthma.In this genome-wide association study, we used a two-stage case-control design. In stage 1, genotyped patient-level data from two UK cohorts (the Genetics Asthma Severity Phenotypes [GASP] initiative the Unbiased BIOmarkers...
Active smoking in asthma is associated with worsening of symptoms, accelerated decline lung function, and impaired response to corticosteroids.To examine the short-term effects cessation on airway inflammation, corticosteroid responsiveness smokers asthma.Smokers were given option quit or continue smoking. Both groups underwent spirometry induced sputum at baseline 1, 3, 6 wk. Cutaneous vasoconstrictor topical beclometasone, oral prednisolone, sensitivity peripheral blood lymphocytes...
Abstract Statins, the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, are effective serum cholesterol-lowering agents in clinical practice, and they may also have anti-inflammatory properties. Asthma is characterized by chronic eosinophilic inflammation airways, which thought to be regulated activity of T lymphocytes. We therefore examined simvastatin a murine model allergic asthma. In mice previously sensitized OVA, treatment, either orally or i.p., reduced total inflammatory cell...
No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease.We tested hypothesis that inhaled combined long-acting beta2-agonist (salmeterol) and corticosteroid (fluticasone propionate) will inflammation.Bronchial biopsies induced sputum were taken from 140 current former smokers (mean age, 64 yr) with moderate severe disease, randomized in a 13-wk double-blind study placebo (n = 73) or salmeterol/fluticasone...
<h3>Background</h3> The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild moderate disease and risk factors severe remain unclear. <h3>Objective</h3> To identify common variants affecting susceptibility asthma. <h3>Methods</h3> A genome-wide study was undertaken in 933 European ancestry individuals with based Global Initiative Asthma (GINA) criteria 3 or above 3346 clean controls. After standard quality control...